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Time course of cytokine levels in sepsis

Time course of cytokine levels in sepsis 134 21 21 2 2 L. G. Thijs C. E. Hack Medical Intensive Care Unit and Institute for Cardiovascular Research (ICaR-VU) Free University Hospital P.O. Box 7057 NL-1007 MB Amsterdam The Netherlands Central Laboratory of the Netherlands Red Cross Blood Transfusion Service Amsterdam The Netherlands Abstract In severe sepsis, a network of proinflammatory cytokines (TNF, IL-lß, IL-6, IL-8) is activated and blood levels of these cytokines are elevated, albeit inconsistently and with large individual variations. In addition, elevated blood levels of anti-inflammatory cytokines (IL-10), as well as of soluble cytokine receptors (sTNF-RI and II, IL-lra), have been found. They seem to have a regulatory function in the host response. Levels of TNF and IL-6 are usually highest at the time of admission, whereas the time course of IL-lß levels (when detectable) can vary considerably. Limited data on IL-8 levels suggest that they may remain elevated for longer periods. Elevated levels of sTNFR and IL-lra may also persist for a prolonged period of time. The pathogenetic significance of these observations is still unclear, but persistingly high levels of proinflammatory cytokines may be associated with organ failure and mortality. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Intensive Care Medicine Springer Journals

Time course of cytokine levels in sepsis

Thijs, L.; Hack, C.
Intensive Care Medicine , Volume 21 (2) – Nov 1, 1995
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References (34)

Publisher
Springer Journals
Copyright
Copyright © 1995 by Springer-Verlag
Subject
Medicine & Public Health; Anesthesiology; Emergency Medicine; Intensive / Critical Care Medicine; Pneumology/Respiratory System; Pain Medicine; Pediatrics
ISSN
0342-4642
eISSN
1432-1238
DOI
10.1007/BF01740764
Publisher site
See Article on Publisher Site

Abstract

134 21 21 2 2 L. G. Thijs C. E. Hack Medical Intensive Care Unit and Institute for Cardiovascular Research (ICaR-VU) Free University Hospital P.O. Box 7057 NL-1007 MB Amsterdam The Netherlands Central Laboratory of the Netherlands Red Cross Blood Transfusion Service Amsterdam The Netherlands Abstract In severe sepsis, a network of proinflammatory cytokines (TNF, IL-lß, IL-6, IL-8) is activated and blood levels of these cytokines are elevated, albeit inconsistently and with large individual variations. In addition, elevated blood levels of anti-inflammatory cytokines (IL-10), as well as of soluble cytokine receptors (sTNF-RI and II, IL-lra), have been found. They seem to have a regulatory function in the host response. Levels of TNF and IL-6 are usually highest at the time of admission, whereas the time course of IL-lß levels (when detectable) can vary considerably. Limited data on IL-8 levels suggest that they may remain elevated for longer periods. Elevated levels of sTNFR and IL-lra may also persist for a prolonged period of time. The pathogenetic significance of these observations is still unclear, but persistingly high levels of proinflammatory cytokines may be associated with organ failure and mortality.

Journal

Intensive Care Medicine – Springer Journals

Published: Nov 1, 1995

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