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U. Wahn, J. Bos, M. Goodfield, R. Caputo, K. Papp, A. Manjra, A. Dobozy, C. Paul, S. Molloy, T. Hultsch, M. Graeber, R. Cherill, Y. Prost (2002)
Efficacy and safety of pimecrolimus cream in the long-term management of atopic dermatitis in children.Pediatrics, 110 1 Pt 1
K. Papp, T. Werfel, R. Fölster-Holst, J. Ortonne, P. Potter, Y. Prost, M. Davidson, N. Barbier, H. Goertz, C. Paul (2005)
Long-term control of atopic dermatitis with pimecrolimus cream 1% in infants and young children: a two-year study.Journal of the American Academy of Dermatology, 52 2
Wellington Wellington, Noble Noble (2004)
Pimecrolimus: a review of its use in atopic dermatitisAm J Clin Dermatol, 5
Papp Papp, Werfel Werfel, Fölster‐Holst Fölster‐Holst (2005)
Long‐term control of atopic dermatitis with pimecrolimus cream 1% in infants: a 2‐year studyJ Am Acad Dermatol, 52
K. Wellington, S. Noble (2004)
PimecrolimusAmerican Journal of Clinical Dermatology, 5
Elidel (pimecrolimus) Cream and Protopic (tacrolimus) Ointment
B. Allen, M. Lakhanpaul, A. Morris, S. Lateo, T. Davies, G. Scott, M. Cardno, M. Ebelin, P. Burtin, T. Stephenson (2003)
Systemic exposure, tolerability, and efficacy of pimecrolimus cream 1% in atopic dermatitis patientsArchives of Disease in Childhood, 88
K. Rappersberger, M. Komar, M. Ebelin, G. Scott, P. Burtin, G. Greig, J. Kehren, S. Chibout, A. Cordier, W. Holter, L. Richter, R. Oberbauer, A. Stuetz, K. Wolff (2002)
Pimecrolimus identifies a common genomic anti-inflammatory profile, is clinically highly effective in psoriasis and is well tolerated.The Journal of investigative dermatology, 119 4
D. Staab, D. Pariser, A. Gottlieb, R. Kaufmann, L. Eichenfield, R. Langley, G. Scott, M. Ebelin, Denise Barilla, H. Schmidli, P. Burtin (2005)
Low Systemic Absorption and Good Tolerability of Pimecrolimus, Administered as 1% Cream (Elidel®) in Infants with Atopic Dermatitis – A Multicenter, 3‐Week, Open‐Label StudyPediatric Dermatology, 22
K. Papp, K. Breuer, M. Meurer, J. Ortonne, P. Potter, Y. Prost, M. Davidson, N. Barbier, H. Goertz, C. Paul (2005)
Long-term treatment of atopic dermatitis with pimecrolimus cream 1% in infants does not interfere with the development of protective antibodies after vaccination.Journal of the American Academy of Dermatology, 52 2
Food and Drug Administration Pediatric Advisory Committee. Briefing Information
E. Leent, M. Ebelin, P. Burtin, B. Dorobek, P. Spuls, J. Bos (2002)
Low Systemic Exposure after Repeated Topical Application of Pimecrolimus (Elidel®, SD Z ASM 981) in Patients with Atopic DermatitisDermatology, 204
M. Grassberger, Martin Steinhoff, D. Schneider, T. Luger (2004)
Pimecrolimus – an anti‐inflammatory drug targeting the skinExperimental Dermatology, 13
Abstract: Systemic drug exposure following the application of topical agents is a very important safety consideration, particularly in infants, who have a significantly higher ratio of body surface area to body mass than older children and adults. Here, we report on drug exposure in five infants aged 5.7–11.9 months at baseline, with extensive, moderate‐to‐severe atopic dermatitis (AD). Patients were treated bid for 1 year, as needed, with pimecrolimus cream 1% in an open‐label, non‐controlled study. No indication of drug accumulation was found; pimecrolimus blood concentrations were consistently low, ranging from below the limit of quantitation (0.1 ng/ml) to 1.94 ng/ml. Treatment over this prolonged period was well tolerated, with no evidence of any treatment‐related adverse events. The results of this 1‐year study indicate that long‐term management of AD with pimecrolimus cream 1% is associated with consistently very low systemic absorption, even in the youngest patients with extensive disease.
Experimental Dermatology – Wiley
Published: Feb 1, 2006
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