Access the full text.
Sign up today, get DeepDyve free for 14 days.
B. Fisher, D. Wickerham, A. Brown, C. Redmond (1983)
Breast cancer estrogen and progesterone receptor values: their distribution, degree of concordance, and relation to number of positive axillary nodes.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1 6
Tulasan Tulasan, Hamann Hamann, Prestele Prestele, Ramming Ramming, Maillot Maillot, Egger Egger (1982)
Correlations of the receptor content and ultrastructure of breast cancer cellsArch Gynecol, 231
Hamann M . Prestele H . Rammine I
PR (fmol/mg)
G. Vitola, G. Zeĭkate, I. Grabovska (1987)
[Progesterone receptors in breast cancer].Voprosy onkologii, 33 9
K. Mccarty, T. Barton, B. Fetter, B. Woodard, Jeffrey Mossler, W. Reeves, J. Daly, W. Wilkinson, K. Mccarty (1980)
Correlation of estrogen and progesterone receptors with histologic differentiation in mammary carcinomaCancer, 46
W. McGuire, K. Horwitz, O. Pearson, A. Segaloff (1977)
Current status of estrogen and progesterone receptors in breast cancerCancer, 39
MD MEYER, PHD' RAO, Phd STEVENS, BS WHITE, Harold Briggs, M. Cantley, Rhoda Facher, JoAnne Stuerman, N. Dillen, B. Hixon (1977)
Low incidence of estrogen receptor in breast carcinomas with rapid rates of cellular replicationCancer, 40
Rolland Rolland, Jacquemier Jacquemier, Martin Martin (1980)
Histological differentiation in human breast cancer is related to steroid receptors and stromal elastosisCancer Chemother Pharmacol, 5
Fisher Fisher, Osborne Osborne, McGuire McGuire (1981)
Correlation of primary breast cancer histopathology and estrogen receptor contentBreast Cancer Res Treat, 1
K. Horwitz, W. McGuire, O. Pearson, A. Segaloff (1975)
Predicting response to endocrine therapy in human breast cancer: a hypothesis.Science, 189 4204
R. Millis (1980)
Correlation of hormone receptors with pathological features in human breast cancerCancer, 46
(1984)
Tumor nuclear grade , estrogen or progesterone receptor alone or in combination : Their value as indicators of outcome following adjuvant therapy for breast cancer
N. Bloom, E. Tobin, B. Schreibman, G. Degenshein (1980)
The role of progesterone receptors in the management of advanced breast cancerCancer, 45
(1984)
Proliferative activity and ploidy of primary breast cancer in relationship to estrogen receptor ( ER ) and nuclear grade
Martin Martin, Rolland Rolland, Jacquemier Jacquemier (1979)
Multiple steroid receptors in human breast cancer: II. Estrogen and progesterone receptors in 672 primary tumorsCancer Chemother Pharmacol, 2
R. Bryan, Ronald Mercer, R. Bennett, G. Rennie, Tat Lie, F. Morgan (1984)
Progesterone receptors in breast cancer.The Australian and New Zealand journal of surgery, 54 3
B. Fisher, C. Redmond, A. Brown, D. Wickerham, N. Wolmark, J. Allegra, G. Escher, M. Lippman, E. Savlov, J. Wittliff (1983)
Influence of tumor estrogen and progesterone receptor levels on the response to tamoxifen and chemotherapy in primary breast cancer.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1 4
E. Fisher, C. Redmond, Hannen Liu, H. Rockette, B. Fisher (1980)
Correlation of estrogen receptor and pathologic characteristics of invasive breast cancerCancer, 45
S. Edition, N. Nie, K. Steinbrenner (1970)
Statistical Package for the Social Sciences
P. Young, C. Ehrlich, L. Einhorn (1980)
Relationship between steroid receptors and response to endocrine therapy and cytotoxic chemotherapy in metastatic breast cancerCancer, 46
Lesser Lesser, Rosen Rosen, Senie Senie (1981)
Estrogen and progesterone receptors in human breast cancers: Correlation with epidemiology and pathologyCancer, 48
S. Cutler, F. Ederer (1958)
Maximum utilization of the life table method in analyzing survival.Journal of chronic diseases, 8 6
A. Sarrif, J. Durant (1981)
Evidence that estrogen‐receptor‐negative, progesterone‐receptor‐positive breast and ovarian carcinomas contain estrogen receptorCancer, 48
K. Matsumoto, H. Ochi, Y. Nomura, O. Takatani, M. Izuo, R. Okamoto, H. Sugano (1978)
Progesterone and estrogen receptors in Japanese breast cancer.
A. Alanko, J. Makinen, T. Scheinin, E. Tolppanen, R. Vihko (2009)
Correlation of estrogen and progesterone receptors and histological grade in human primary breast cancer.Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology, 92 5
Noshimura Noshimura, Misuni Misuni, Kimura Kimura, Tokunaga Tokunaga, Akagi Akagi (1982)
Relationship between the content of estrogen and progesterone receptors and the pathological characteristics in human breast cancerJpn J Surg, 12
Martin Lesser, P. Rosen, R. Senie, Kathleen Duthie, C. Menendez-Botet, M. Schwartz (1981)
Estrogen and progesterone receptors in breast carcinoma: Correlations with epidemiology and pathologyCancer, 48
E. Fisher, C. Redmond, B. Fisher (1980)
Pathologic findings from the national surgical adjuvant breast project (protocol no. 4) vi. discriminants for five‐year treatment failureCancer, 46
E. Fisher, R. Gregorio, B. Fisher, F. Vellios, S. Sommers (1975)
The pathology of invasive breast cancer A Syllabus Derived from Findings of the National Surgical Adjuvant Breast Project (Protocol No. 4)Cancer, 36
E. Fisher, R. Sass, B. Fisher (1984)
Pathologic findings from the national surgical adjuvant project for breast cancers (protocol no. 4) X. Discriminants for tenth year treatment failureCancer, 53
Pathologic materials were available for review from 1597 women with Stage II (positive regional node metastases) invasive breast cancer in whom estrogen receptor (ER) and progesterone receptor (PR) assays of the primary tumor were performed. These women were enrolled in a clinical trial comparing the effect of postmastectomy adjuvant L‐phenylalanine mustard (L‐PAM) and 5‐fluorouracil (5‐FU) with and without tamoxifen (NSABP Protocol No. 9). Significant pathologic and clinical associations with receptor status were similar for both ER and PR except that the latter, unlike ER, was not related to patient age. Regression analyses revealed that the most significant pathologic features related to a concordant positive ERPR receptor status was low (well differentiated) nuclear and histologic grades, slight or absent tumor lymphoid infiltrate, slight or absent necrosis and moderate or marked elastica in decreasing order of importance. All of the factors enumerated are directly or indirectly related to tumor differentiation. Recognition of four or five conforming pathologic features allows for the prediction of either ER or PR status in 70% to 80% of instances respectively, and the presence of three features in 69%. This latter figure is similar to that of estimation of nuclear grade alone. Thirty percent of ERPR estimates were discordant i.e., either ER‐PR+ or ER+PR‐. Pathologic features associated with discordant assays were not similar to those found when the ERPR estimates were concordant. Life table analyses revealed patients with discordant receptors to exhibit disease‐free survival intermediate to that of those with ER+PR+ and ER‐PR‐ values. This information suggests that a discordant receptor status is more reflective of an aberration of ER metabolism than a methodologic error. Histograms correlating frequency of nuclear grades with levels of ER and PR were comparable and revealed patterns indicating the propriety of relating values less than 10 fm/mg as being receptor negative. The frequency of well‐differentiated nuclei increased with ascending levels of ER and PR.
Cancer – Wiley
Published: May 1, 1987
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.