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J. of Cardiovasc. Trans. Res. (2011) 4:523–527 DOI 10.1007/s12265-011-9287-x The Biocompatibility Manifesto: Biocompatibility for the Twenty-first Century Buddy D. Ratner Received: 26 March 2011 /Accepted: 23 May 2011 /Published online: 28 June 2011 Springer Science+Business Media, LLC 2011 Introduction—The Challenge (for example, see [1]). Though many of these early observations were accurate, the word “biocompatible” was The eighteenth and nineteenth centuries were shaped by never used. By 1970, a few papers appeared that used the steam power and industrialization. The twentieth century word “biocompatible.” According to the biocompatibility saw electricity and nuclear energy. Most prognosticators article in Wikipedia, “The word biocompatibility seems have posit that the twenty-first century will be the century of been mentioned for the first time in peer-review journals and biology. Concepts of biocompatibility were developed at meetings in 1970 by RJ Hegyeli (Amer Chem Soc Annual about the same time that cytokines and cell surface Meeting abstract) and CA Homsy et al. (J Macromol Sci receptors were discovered, and these seminal discoveries Chem A4:3,615,1970).” Thus, I believe it is accurate to trace were never integrated into early biocompatibility definitions. the first thinking about how a material should appropriately Now is the appropriate time, the century
Journal of Cardiovascular Translational Research – Springer Journals
Published: Jun 28, 2011
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