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IMPACT OF OBESITY AND INSULIN RESISTANCE ON VASOMOTOR TONE: NITRIC OXIDE AND BEYOND

IMPACT OF OBESITY AND INSULIN RESISTANCE ON VASOMOTOR TONE: NITRIC OXIDE AND BEYOND 1 Obesity is rapidly increasing in Western populations, driving a parallel increase in hypertension, diabetes and vascular disease. Prior to the development of overt diabetes or hypertension, obese patients spend years in a state of progressive insulin resistance and metabolic disease. Mounting evidence suggests that this insulin‐resistant state has deleterious effects on the control of blood flow, thus placing organ systems at a higher risk for end‐organ damage and increasing cardiovascular mortality. 2 The purpose of the present review is to examine the current literature on the effects of obesity and insulin resistance on the acute control of vascular tone. Effects on nitric oxide (NO)‐mediated control of vascular tone are particularly examined with regard to proximal causes and distal mechanisms of the impaired NO‐mediation of vasodilation. 3 Finally, novel pathways of impaired control of perfusion are summarized from the recent literature to identify new avenues of exploring impaired vascular function in patients with metabolic disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Experimental Pharmacology and Physiology Wiley

IMPACT OF OBESITY AND INSULIN RESISTANCE ON VASOMOTOR TONE: NITRIC OXIDE AND BEYOND

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References (136)

Publisher
Wiley
Copyright
Copyright © 2006 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0305-1870
eISSN
1440-1681
DOI
10.1111/j.1440-1681.2006.04381.x
pmid
16700872
Publisher site
See Article on Publisher Site

Abstract

1 Obesity is rapidly increasing in Western populations, driving a parallel increase in hypertension, diabetes and vascular disease. Prior to the development of overt diabetes or hypertension, obese patients spend years in a state of progressive insulin resistance and metabolic disease. Mounting evidence suggests that this insulin‐resistant state has deleterious effects on the control of blood flow, thus placing organ systems at a higher risk for end‐organ damage and increasing cardiovascular mortality. 2 The purpose of the present review is to examine the current literature on the effects of obesity and insulin resistance on the acute control of vascular tone. Effects on nitric oxide (NO)‐mediated control of vascular tone are particularly examined with regard to proximal causes and distal mechanisms of the impaired NO‐mediation of vasodilation. 3 Finally, novel pathways of impaired control of perfusion are summarized from the recent literature to identify new avenues of exploring impaired vascular function in patients with metabolic disease.

Journal

Clinical and Experimental Pharmacology and PhysiologyWiley

Published: May 1, 2006

Keywords: ; ; ; ; ;

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