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Antioxidants and lipid peroxidation status in the blood of patients with alopecia

Antioxidants and lipid peroxidation status in the blood of patients with alopecia The aim of this research was to determine levels in blood of vitamin E, beta‐carotene, lipid peroxidation as thiobarbituric‐acid reactive substances (TBARS) and reduced glutathione (GSH) and activity of glutathione peroxidase (GSH‐Px) in patients with alopecia. Studies were carried out on 37 patients with alopecia and 34 healthy age‐matched controls. Red blood cell (RBC) and plasma samples from healthy and patient subjects were taken. Beta‐cartotene levels (P<0·001) in plasma and levels of GSH (P>0·05) and the activity of GSH‐Px (P<0·05, P<0·01) in both plasma and RBC samples were significantly lower in patients with alopecia than in controls, whereas TBARS levels in plasma (P<0·05) and RBC (P<0·001) samples were significantly higher in patients with alopecia than in controls. However, vitamin E levels in plasma did not differ statistically. Although being far from conclusive, these results provide some evidence for a potential role of increased lipid peroxidation and decreased antioxidants in alopecia. Copyright © 2000 John Wiley & Sons, Ltd. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cell Biochemistry and Function Wiley

Antioxidants and lipid peroxidation status in the blood of patients with alopecia

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References (36)

Publisher
Wiley
Copyright
Copyright © 2000 John Wiley & Sons, Ltd.
ISSN
0263-6484
eISSN
1099-0844
DOI
10.1002/1099-0844(200009)18:3<169::AID-CBF870>3.0.CO;2-T
pmid
10965354
Publisher site
See Article on Publisher Site

Abstract

The aim of this research was to determine levels in blood of vitamin E, beta‐carotene, lipid peroxidation as thiobarbituric‐acid reactive substances (TBARS) and reduced glutathione (GSH) and activity of glutathione peroxidase (GSH‐Px) in patients with alopecia. Studies were carried out on 37 patients with alopecia and 34 healthy age‐matched controls. Red blood cell (RBC) and plasma samples from healthy and patient subjects were taken. Beta‐cartotene levels (P<0·001) in plasma and levels of GSH (P>0·05) and the activity of GSH‐Px (P<0·05, P<0·01) in both plasma and RBC samples were significantly lower in patients with alopecia than in controls, whereas TBARS levels in plasma (P<0·05) and RBC (P<0·001) samples were significantly higher in patients with alopecia than in controls. However, vitamin E levels in plasma did not differ statistically. Although being far from conclusive, these results provide some evidence for a potential role of increased lipid peroxidation and decreased antioxidants in alopecia. Copyright © 2000 John Wiley & Sons, Ltd.

Journal

Cell Biochemistry and FunctionWiley

Published: Sep 1, 2000

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