Access the full text.
Sign up today, get DeepDyve free for 14 days.
I. Graham, Leslie Daly, H. Refsum, Killian Robinson, L. Brattström, P. Ueland, R. Palma-Reis, G. Boers, Richard Sheahan, Bo Israelsson, C. Uiterwaal, R. Meleady, Dorothy McMaster, Petra Verhoef, J. Witteman, P. Rubba, Hélène Bellet, Jan Wautrecht, Harold Valk, A. Luis, Francoise Parrot-Roulaud, Kok Tan, I. Higgins, Danielle Garcon, Maria Medrano, Mirande Candito, Alun Evans, Generoso Andria (1997)
Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project.JAMA, 277 22
H. Mcilwain, J. Poll (1985)
Interaction between adenosine generated endogenously in neocortical tissues, and homocysteine and its thiolactoneNeurochemistry International, 7
Takamasa Kishi, Naoto Fujita, T. Eguchi, K. Ueda (1997)
Mechanism for reduction of serum folate by antiepileptic drugs during prolonged therapyJournal of the Neurological Sciences, 145
H. Ono, A. Sakamoto, T. Eguchi, N. Fujita, S. Nomura, H. Ueda, N. Sakura, K. Ueda (1997)
Plasma total homocysteine concentrations in epileptic patients taking anticonvulsants.Metabolism: clinical and experimental, 46 8
S. Schwarz, Guang-zhao Zhou (1991)
N-methyl-D-aspartate receptors and CNS symptoms of homocystinuriaThe Lancet, 337
M. Stampfer, M. Malinow, W. Willett, L. Newcomer, B. Upson, D. Ullmann, P. Tishler, C. Hennekens (1992)
A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians.JAMA, 268 7
W. Freed (1985)
Selective Inhibition of Homocysteine‐Induced Seizures by Glutamic Acid Diethyl Ester and Other Glutamate EstersEpilepsia, 26
A. Verrotti, S. Domizio, B. Angelozzi, G. Sabatino, G. Morgese, F. Chiarelli (1997)
Changes in serum lipids and lipoproteins in epileptic children treated with anticonvulsantsJournal of Paediatrics and Child Health, 33
F. Klipstein (1964)
SUBNORMAL SERUM FOLATE AND MACROCYTOSIS ASSOCIATED WITH ANTICONVULSANT DRUG THERAPY.Blood, 23
J. Isojärvi, Arto Pakarinen, Vilho Myllylä (1993)
Serum lipid levels during carbamazepine medication. A prospective study.Archives of neurology, 50 6
P. Marangos, T. Loftus, J. Wiesner, T. Lowe, E. Rossi, Clinton Browne, Harry Gruber (1990)
Adenosinergic Modulation of Homocysteine‐Induced Seizures in MiceEpilepsia, 31
J. Selhub, P. Jacques, P. Wilson, D. Rush, I. Rosenberg (1993)
Vitamin status and intake as primary determinants of homocysteinemia in an elderly population.JAMA, 270 22
R. May, T. Sunder (1993)
Hematologic Manifestations of Long‐Term Valproate TherapyEpilepsia, 34
H. Kubová, H. Kubová, J. Folbergrová, P. Mareš, P. Mareš (1995)
Seizures Induced by Homocysteine in Rats During OntogenesisEpilepsia, 36
E. Calandre, B. Porta, Dolores Calzada (1992)
The Effect of Chronic Phenytoin Treatment on Serum Lipid Profile in Adult Epileptic PatientsEpilepsia, 33
Jesús Eirís, S. Lojo, M. Rio, I. Novo, M. Bravo, P. Pavón, M. Castro-Gago (1995)
Effects of long‐term treatment with antiepileptic drugs on serum lipid levels in children with epilepsyNeurology, 45
S. Mudd, F. Skovby, H. Levy, Pettigrew Kd, B. Wilcken, Pyeritz Re, G. Andria, G. Boers, Bromberg Il, R. Cerone (1985)
The natural history of homocystinuria due to cystathionine beta-synthase deficiency.American journal of human genetics, 37 1
R. Clarke, Peter Woodhouse, A. Ulvik, Chris Frost, P. Sherliker, H. Refsum, P. Ueland, K. Khaw (1998)
Variability and determinants of total homocysteine concentrations in plasma in an elderly population.Clinical chemistry, 44 1
D. Dastur, U. Dave (1987)
Effect of Prolonged Anticonvulsant Medication in Epileptic Patients: Serum Lipids, Vitamins B6, B12, and Folic Acid, Proteins, and Fine Structure of LiverEpilepsia, 28
J. Edeh, B. Toone (1985)
Antiepileptic Therapy, Folate Deficiency, and Psychiatric Morbidity: A General Practice SurveyEpilepsia, 26
M. Dalton, Preston Gadson, R. Wrenn, T. Rosenquist (1997)
Homocysteine signal cascade: production of phospholipids, activation of protein kinase C, and the induction of c‐fos and c‐myb in smooth muscle cellsThe FASEB Journal, 11
Graham Graham, Daly Daly, Refsum Refsum, Robinson Robinson, Brattström Brattström (1997)
Plasma homocysteine as a risk factor for vascular diseaseJAMA, 277
E. Reynolds, I. Chanarin, G. Milner, D. Matthews (1966)
Anticonvulsant Therapy, Folic Acid and Vitamin B12 Metabolism and Mental SymptomsEpilepsia, 7
I. Chanarin, J. Laidlaw, L. Loughridge, D. Mollin (1960)
Megaloblastic Anaemia Due to PhenobarbitoneBritish Medical Journal, 1
K. Krause, J. Bonjour, P. Berlit, G. Kynast, H. Schmidt-Gayk, B. Schellenberg (1988)
Effect of long-term treatment with antiepileptic drugs on the vitamin status.Drug-nutrient interactions, 5 4
L. Reinken (1975)
The influence of antiepileptic drugs on vitamin B6 metabolism.Acta vitaminologica et enzymologica, 29 1-6
E. Reynolds (1967)
Effects of folic acid on the mental state and fit-frequency of drug-treated epileptic patients.Lancet, 1 7499
Gibberd Gibberd, Nicholls Nicholls, Wright Wright (1981)
The influence of folic acid on the frequency of epileptic attacksEur J Clin Pharmacol, 19
Chanarin Chanarin, Laidlaw Laidlaw, Loughbridge Loughbridge, Mollin Mollin (1960)
Megaloblastic anaemia due to phenobarbitone: the convulsant action of therapeutic doses of folic acidBr Med J, 1
Antti Muuronen, Markku Kaste, Esko Nikkila, ESA-MATTI Tolppanen, M. Bsc (1985)
Mortality from ischaemic heart disease among patients using anticonvulsive drugs: a case-control study.British Medical Journal (Clinical research ed.), 291
S. Schwarz, G. Zhou, A. Katki, D. Rodbard (1990)
l-Homocysteate stimulates [3H]MK-801 binding to the phencyclidine recognition site and is thus an agonist for the N-methyl-d-aspartate-operated cation channelNeuroscience, 37
M. Stampfer, Malinow Mr (1995)
Can lowering homocysteine levels reduce cardiovascular risk?The New England journal of medicine, 332 5
M. Botez, S. Young (1991)
Effects of anticonvulsant treatment and low levels of folate and thiamine on amine metabolites in cerebrospinal fluid.Brain : a journal of neurology, 114 ( Pt 1A)
R. Mattson, B. Gallagher, E. Reynolds, D. Glass (1973)
Folate therapy in epilepsy. A controlled study.Archives of neurology, 29 2
Reynolds Reynolds, Chanarin Chanarin, Milner Milner, Matthews Matthews (1966)
Anticonvulsant folic acid and vitamin B 12 metabolism and mental symptomsEpilepsia, 7
W. Fröscher, V. Maier, M. Laage, M. Wolfersdorf, R. Straub, J. Rothmeier, T. Steinert, A. Fiaux, U. Frank, D. Grupp (1995)
Folate deficiency, anticonvulsant drugs, and psychiatric morbidity.Clinical neuropharmacology, 18 2
B. Vester, K. Rasmussen (1991)
High Performance Liquid Chromatography Method for Rapid and Accurate Determination of Homocysteine in Plasma and Serum, 29
P. Ueland, Helga Refsum (1989)
Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy.The Journal of laboratory and clinical medicine, 114 5
K. Hyland, T. Bottiglieri (1992)
Measurement of total plasma and cerebrospinal fluid homocysteine by fluorescence following high-performance liquid chromatography and precolumn derivatization with o-phthaldialdehyde.Journal of chromatography, 579 1
J. Selhub, P. Jacques, A. Bostom, R. D’Agostino, P. Wilson, A. Belanger, D. O'leary, P. Wolf, E. Schaefer, I. Rosenberg (1995)
Association between plasma homocysteine concentrations and extracranial carotid-artery stenosis.The New England journal of medicine, 332 5
Isojärvi Isojärvi, Pakarinen Pakarinen, Myllylä Myllylä (1993)
Serum lipid levels during carbamazepine medicationArch Neurol, 50
Mattson Mattson, Gallagher Gallagher, Reynolds Reynolds, Glass Glass (1973)
Folate therapy in epilepsyArch Neurol, 29
Summary: Purpose: Homocysteine is an experimental convulsant and an established risk factor in atherosclerosis. A nuritional deficiency of vitamin B6, vitamin B12, or folate leads to increased homocysteine plasma concentrations. During treatment with carbamazepine (CBZ), phenytoin, or phenobarbital, a deficiency in these vitamins is common. The objective of the study was to test the hypothesis that antiepileptic drug (AED) treatment is associated with increased homocysteine plasma concentrations. Methods: A total of 51 consecutive outpatients of our epilepsy clinic receiving stable, individually adjusted AED treatment and 51 sex‐ and age‐matched controls were enrolled in the study. Concentrations of total homocysteine and vitamin B6 were measured in plasma; vitamin B12 and folate were measured in the serum of fasted subjects. Results: Patients and controls differed significantly in concentrations of folate (13.5 ± 1.0 vs. 17.4 ± 0.8 nM and vitamin B6 (39.7 ± 3.4 vs. 66.2 ± 7.5 nM), whereas serum concentrations of vitamin B12 were similar. The homocysteine plasma concentration was significantly increased to 14.7 ± 3.0 μM in patients compared with controls (9.5 ± 0.5 μM; p < 0.05, Wilcoxon rank‐sum test). The number of patients with concentrations of >15 μM was significantly higher in the patient group than among controls. The same result was obtained if only patients with CBZ monotherapy were included. Patients with increased homocysteine plasma concentrations had lower folate concentrations. Conclusions: These data support the hypothesis that prolonged AED treatment may increase plasma concentrations of homocysteine, although the alternative explanation that increased homocysteine plasma concentrations are associated with the disease and not the treatment cannot be completely excluded at the moment.
Epilepsia – Wiley
Published: Mar 1, 1999
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.