Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Influence of histamine depletion on learning and memory recollection in rats

Influence of histamine depletion on learning and memory recollection in rats 213 111 111 3 3 Chiaki Kamei Yasushi Okumura Kenji Tasaka Department of Pharmacology, Faculty of Pharmaceutical Sciences Okayama University 700 Okayama Japan Abstract To clarify the role of endogenous histamine in learning and memory, the effect of α-fluoromethylhistidine on active avoidance response in rats was studied. α-Fluoromethylhistidine (20–100 mg/kg or 10–50 µg) significantly ( P <0.05 or P <0.01) prolonged the response latency in active avoidance response when administered by either intraperitoneal or intracerebroventricular injection. These effects were dose-related and long lasting. A prolongation of the response latency induced by an intraperitoneal injection of α-fluoromethylhistidine (100 mg/kg) was antagonized by intracerebroventricular injection of histamine (10 and 20 ng) in a dose-dependent manner. In addition, the acquisition of this response was retarded by a consecutive intracerebroventricular injection of α-fluoromethylhistidine (50 µg), whereas histamine (100 ng) facilitated the response acquisition when administered by the same route. Both intraperitoneal (100 mg/kg) and intracerebroventricular injection of α-fluoromethylhistidine (50 µg) significantly ( P <0.05 or P <0.01) decreased the brain histamine content, especially in the hippocampus and hypothalamus. When α-fluoromethylhistidine (50 µg) was injected intracerebroventricularly, there is a high correlation between a prolongation of the response latency and a decrease in histamine content of these brain areas. Based on these findings, it was concluded that an intimate relation may exist between a prolongation of response latency in the active avoidance response and a decrease in the brain histamine content; endogenous histamine may play an important role in learning and memory recollection in rats. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Influence of histamine depletion on learning and memory recollection in rats

Psychopharmacology , Volume 111 (3) – Jun 1, 1993

Loading next page...
 
/lp/springer-journals/influence-of-histamine-depletion-on-learning-and-memory-recollection-AWOJxDUFwv

References (36)

Publisher
Springer Journals
Copyright
Copyright © 1993 by Springer-Verlag
Subject
Biomedicine; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
DOI
10.1007/BF02244955
Publisher site
See Article on Publisher Site

Abstract

213 111 111 3 3 Chiaki Kamei Yasushi Okumura Kenji Tasaka Department of Pharmacology, Faculty of Pharmaceutical Sciences Okayama University 700 Okayama Japan Abstract To clarify the role of endogenous histamine in learning and memory, the effect of α-fluoromethylhistidine on active avoidance response in rats was studied. α-Fluoromethylhistidine (20–100 mg/kg or 10–50 µg) significantly ( P <0.05 or P <0.01) prolonged the response latency in active avoidance response when administered by either intraperitoneal or intracerebroventricular injection. These effects were dose-related and long lasting. A prolongation of the response latency induced by an intraperitoneal injection of α-fluoromethylhistidine (100 mg/kg) was antagonized by intracerebroventricular injection of histamine (10 and 20 ng) in a dose-dependent manner. In addition, the acquisition of this response was retarded by a consecutive intracerebroventricular injection of α-fluoromethylhistidine (50 µg), whereas histamine (100 ng) facilitated the response acquisition when administered by the same route. Both intraperitoneal (100 mg/kg) and intracerebroventricular injection of α-fluoromethylhistidine (50 µg) significantly ( P <0.05 or P <0.01) decreased the brain histamine content, especially in the hippocampus and hypothalamus. When α-fluoromethylhistidine (50 µg) was injected intracerebroventricularly, there is a high correlation between a prolongation of the response latency and a decrease in histamine content of these brain areas. Based on these findings, it was concluded that an intimate relation may exist between a prolongation of response latency in the active avoidance response and a decrease in the brain histamine content; endogenous histamine may play an important role in learning and memory recollection in rats.

Journal

PsychopharmacologySpringer Journals

Published: Jun 1, 1993

There are no references for this article.