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J. Guignot, E. Caron, C. Beuzón, C. Bucci, Jonathan Kagan, C. Roy, D. Holden (2004)
Microtubule motors control membrane dynamics of Salmonella-containing vacuolesJournal of Cell Science, 117
J. Lippincott-Schwartz, Theresa Roberts, K. Hirschberg (2000)
Secretory protein trafficking and organelle dynamics in living cells.Annual review of cell and developmental biology, 16
K. Wolf, T. Hackstadt (2001)
Sphingomyelin trafficking in Chlamydia pneumoniae‐infected cellsCellular Microbiology, 3
R. Harrison, J. Brumell, Arian Khandani, C. Bucci, C. Scott, Xiuju Jiang, B. Finlay, S. Grinstein (2004)
Salmonella impairs RILP recruitment to Rab7 during maturation of invasion vacuoles.Molecular biology of the cell, 15 7
Y. Shotland, H. Krämer, E. Groisman (2003)
The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular traffickingMolecular Microbiology, 49
R. Guy, Lauren Gonias, M. Stein (2000)
Aggregation of host endosomes by Salmonella requires SPI2 translocation of SseFG and involves SpvR and the fms–aroE intragenic regionMolecular Microbiology, 37
E. Mitchell, P. Mastroeni, A. Kelly, J. Trowsdale (2004)
Inhibition of cell surface MHC class II expression by SalmonellaEuropean Journal of Immunology, 34
C. Beuzón, S. Méresse, Kate Unsworth, Javier Ruiz-Albert, S. Garvis, S. Waterman, T. Ryder, Emmanuel Boucrot, D. Holden (2000)
Salmonella maintains the integrity of its intracellular vacuole through the action of SifAThe EMBO Journal, 19
D. Chakravortty, Imke Hansen-Wester, M. Hensel (2002)
Salmonella Pathogenicity Island 2 Mediates Protection of Intracellular Salmonella from Reactive Nitrogen IntermediatesThe Journal of Experimental Medicine, 195
R. Valdivia, S. Falkow (1997)
Fluorescence-based isolation of bacterial genes expressed within host cells.Science, 277 5334
S. Grieshaber, N. Grieshaber, T. Hackstadt (2003)
Chlamydia trachomatis uses host cell dynein to traffic to the microtubule-organizing center in a p50 dynamitin-independent processJournal of Cell Science, 116
D. Holden (2002)
Trafficking of the Salmonella Vacuole in MacrophagesTraffic, 3
O. Steele‐Mortimer, S. Méresse, J. Gorvel, B. Toh, B. Finlay (1999)
Biogenesis of Salmonella typhimurium‐containing vacuoles in epithelial cells involves interactions with the early endocytic pathwayCellular Microbiology, 1
M. Hensel, J. Shea, S. Waterman, R. Mundy, T. Nikolaus, G. Banks, A. Vázquez-Torres, Colin Gleeson, F. Fang, D. Holden (1998)
Genes encoding putative effector proteins of the type III secretion system of Salmonella pathogenicity island 2 are required for bacterial virulence and proliferation in macrophagesMolecular Microbiology, 30
D. Toomre, P. Keller, Jamie White, J. Olivo, K. Simons (1999)
Dual-color visualization of trans-Golgi network to plasma membrane traffic along microtubules in living cells.Journal of cell science, 112 ( Pt 1)
Edward Miao, M. Brittnacher, A. Haraga, R. Jeng, M. Welch, Samuel Miller (2003)
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeletonMolecular Microbiology, 48
R. Carabeo, D. Mead, T. Hackstadt (2003)
Golgi-dependent transport of cholesterol to the Chlamydia trachomatis inclusionProceedings of the National Academy of Sciences of the United States of America, 100
J. Brumell, D. Goosney, B. Finlay (2002)
SifA, a Type III Secreted Effector of Salmonella typhimurium, Directs Salmonella‐Induced Filament (Sif) Formation Along MicrotubulesTraffic, 3
K. Datsenko, B. Wanner (2000)
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.Proceedings of the National Academy of Sciences of the United States of America, 97 12
T. Hackstadt, D. Rockey, R. Heinzen, M. Scidmore (1996)
Chlamydia trachomatis interrupts an exocytic pathway to acquire endogenously synthesized sphingomyelin in transit from the Golgi apparatus to the plasma membrane.The EMBO Journal, 15
H. Pelham (2001)
Traffic through the Golgi apparatusThe Journal of Cell Biology, 155
J. Bergmann (1989)
Using temperature-sensitive mutants of VSV to study membrane protein biogenesis.Methods in cell biology, 32
J. Shea, M. Hensel, Colin Gleeson, D. Holden (1996)
Identification of a virulence locus encoding a second type III secretion system in Salmonella typhimurium.Proceedings of the National Academy of Sciences of the United States of America, 93 6
Toomre (1999)
10.1242/jcs.112.1.21J Cell Sci, 112
S. Salcedo, D. Holden (2003)
SseG, a virulence protein that targets Salmonella to the Golgi networkThe EMBO Journal, 22
A. Ang, T. Taguchi, Stephen Francis, H. Fölsch, Lindsay Murrells, M. Pypaert, G. Warren, I. Mellman (2004)
Recycling endosomes can serve as intermediates during transport from the Golgi to the plasma membrane of MDCK cellsThe Journal of Cell Biology, 167
V. Kuhle, Michael Hensel (2004)
Cellular microbiology of intracellular Salmonella enterica: functions of the type III secretion system encoded by Salmonella pathogenicity island 2Cellular and Molecular Life Sciences CMLS, 61
A. Vázquez-Torres, Yisheng Xu, J. Jones-Carson, D. Holden, Scott Lucia, M. Dinauer, P. Mastroeni, F. Fang (2000)
Salmonella pathogenicity island 2-dependent evasion of the phagocyte NADPH oxidase.Science, 287 5458
L. Knodler, Aaron Bestor, Caixia Ma, Imke Hansen-Wester, M. Hensel, B. Vallance, O. Steele‐Mortimer (2005)
Cloning Vectors and Fluorescent Proteins Can Significantly Inhibit Salmonella enterica Virulence in Both Epithelial Cells and Macrophages: Implications for Bacterial Pathogenesis StudiesInfection and Immunity, 73
M. Marsman, Ingrid Jordens, C. Kuijl, L. Janssen, J. Neefjes (2004)
Dynein-mediated vesicle transport controls intracellular Salmonella replication.Molecular biology of the cell, 15 6
N. Nishimura, H. Plutner, K. Hahn, W. Balch (2002)
The δ subunit of AP-3 is required for efficient transport of VSV-G from the trans-Golgi network to the cell surfaceProceedings of the National Academy of Sciences of the United States of America, 99
E. Rodriguez-Boulan, A. Müsch (2005)
Protein sorting in the Golgi complex: shifting paradigms.Biochimica et biophysica acta, 1744 3
L. Hernandez, K. Hueffer, M. Wenk, J. Galán (2004)
Salmonella Modulates Vesicular Traffic by Altering Phosphoinositide MetabolismScience, 304
V. Kuhle, M. Hensel (2002)
SseF and SseG are translocated effectors of the type III secretion system of Salmonella pathogenicity island 2 that modulate aggregation of endosomal compartmentsCellular Microbiology, 4
V. Kuhle, D. Jäckel, M. Hensel (2004)
Effector Proteins Encoded by Salmonella Pathogenicity Island 2 Interfere with the Microtubule Cytoskeleton after Translocation into Host CellsTraffic, 5
K. Uchiya, M. Barbieri, K. Funato, Ankur Shah, P. Stahl, E. Groisman (1999)
A Salmonella virulence protein that inhibits cellular traffickingThe EMBO Journal, 18
L. Knodler, O. Steele‐Mortimer (2003)
Taking Possession: Biogenesis of the Salmonella‐Containing VacuoleTraffic, 4
C. Cheminay, Annette Möhlenbrink, M. Hensel (2005)
Intracellular Salmonella Inhibit Antigen Presentation by Dendritic Cells1The Journal of Immunology, 174
Emmanuel Boucrot, T. Henry, J. Borg, J. Gorvel, S. Méresse (2005)
The Intracellular Fate of Salmonella Depends on the Recruitment of KinesinScience, 308
S. Salcedo, D. Holden (2005)
Bacterial interactions with the eukaryotic secretory pathway.Current opinion in microbiology, 8 1
R. Pagano, O. Martin, H. Kang, R. Haugland (1991)
A novel fluorescent ceramide analogue for studying membrane traffic in animal cells: accumulation at the Golgi apparatus results in altered spectral properties of the sphingolipid precursorThe Journal of Cell Biology, 113
Imke Hansen-Wester, B. Stecher, M. Hensel (2002)
Type III Secretion of Salmonella enterica Serovar Typhimurium Translocated Effectors and SseFGInfection and Immunity, 70
During intracellular life, Salmonella enterica proliferate within a specialized membrane compartment, the Salmonella‐containing vacuole (SCV), and interfere with the microtubule cytoskeleton and cellular transport. To characterize the interaction of intracellular Salmonella with host cell transport processes, we utilized various model systems to follow microtubule‐dependent transport. The vesicular stomatitis virus glycoprotein (VSVG) is a commonly used marker to follow protein transport from the Golgi to the plasma membrane. Using a VSVG‐GFP fusion protein, we observed that virulent intracellular Salmonella alter exocytotic transport and recruit exocytotic transport vesicles to the SCV. This virulence function was dependent on the function of the type III secretion system encoded by Salmonella Pathogenicity Island 2 (SPI2) and more specifically on a subset of SPI2 effector proteins. Furthermore, the Golgi to plasma membrane traffic of the shingolipid C5‐ceramide was redirected to the SCV by virulent Salmonella. We propose that Salmonella modulates the biogenesis of the SCV by deviating this compartment from the default endocytic pathway to an organelle that interacts with the exocytic pathway. This observation might reveal a novel element of the intracellular survival and replication strategy of Salmonella.
Traffic – Wiley
Published: Jun 1, 2006
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