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Telogen skin contains an inhibitor of hair growth

Telogen skin contains an inhibitor of hair growth summary We have investigated whether C 57 Br‐6 mouse skin with all its follicles in the telogen stage of the hair cycle contains a hair‐growth inhibitory activity, as opposed to skin with anagen follicles. Crude aqueous extracts of whole telogen mouse skin (TE), anagen skin (AE) or vehicle alone (V) were injected intraperitoneally into mice in which anagen had previously been induced by plucking of telogen hair follicles. Injection of TE, but not AE or V, significantly retarded the development of anagen follicles, as measured by macroscopic and quantitative microscopic hair growth parameters (skin pigmentation and thickness, appearance of trichohyaline granules) and the incorporation of tritiated thymidine into mouse skin from animals previously treated with either TE or V (skin organ culture). This inhibitory activity seemed to be localized to the epidermis and was also present in rat epidermis. We suggest that this apparently non‐speciesspecific inhibitor present in telogen skin may play a role in regulating the hair cycle in rodents. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Dermatology Wiley

Telogen skin contains an inhibitor of hair growth

PAUS, R.; STENN, K.S.; LINK, R.E.
British Journal of Dermatology , Volume 122 (6) – Jun 1, 1990
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References (21)

Publisher
Wiley
Copyright
Copyright © 1990 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0007-0963
eISSN
1365-2133
DOI
10.1111/j.1365-2133.1990.tb06266.x
Publisher site
See Article on Publisher Site

Abstract

summary We have investigated whether C 57 Br‐6 mouse skin with all its follicles in the telogen stage of the hair cycle contains a hair‐growth inhibitory activity, as opposed to skin with anagen follicles. Crude aqueous extracts of whole telogen mouse skin (TE), anagen skin (AE) or vehicle alone (V) were injected intraperitoneally into mice in which anagen had previously been induced by plucking of telogen hair follicles. Injection of TE, but not AE or V, significantly retarded the development of anagen follicles, as measured by macroscopic and quantitative microscopic hair growth parameters (skin pigmentation and thickness, appearance of trichohyaline granules) and the incorporation of tritiated thymidine into mouse skin from animals previously treated with either TE or V (skin organ culture). This inhibitory activity seemed to be localized to the epidermis and was also present in rat epidermis. We suggest that this apparently non‐speciesspecific inhibitor present in telogen skin may play a role in regulating the hair cycle in rodents.

Journal

British Journal of Dermatology – Wiley

Published: Jun 1, 1990

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