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(1983)
Moss and D.J.G
S. Keyse, S. Moss, D. Davies (1983)
ACTION SPECTRA FOR INACTIVATION OF NORMAL and XERODERMA PIGMENTOSUM HUMAN SKIN FIBROBLASTS BY ULTRAVIOLET RADIATIONSPhotochemistry and Photobiology, 37
Meister Meister, Anderson Anderson (1983)
GlutathioneAnnu. Rev. Biochem., 52
R. Tyrrell, P. Werfelli, E. Moraer (1984)
LETHAL ACTION OF ULTRAVIOLET AND VISIBLE (BLUE‐VIOLET) RADIATIONS AT DEFINED WAVELENGTHS ON HUMAN LYMPHOBLASTOID CELLS: ACTION SPECTRA AND INTERACTION SITESPhotochemistry and Photobiology, 39
Setlow Setlow (1974)
The wavelengths in sunlight effective in producing skin cancer: a theoretical analysisProc. Natl. Acad. Sci. US., 71
H. Niggli, P. Cerutti (1983)
Cyclobutane-type pyrimidine photodimer formation and excision in human skin fibroblasts after irradiation with 313-nm ultraviolet light.Biochemistry, 22 6
R. Setlow (1974)
The wavelengths in sunlight effective in producing skin cancer: a theoretical analysis.Proceedings of the National Academy of Sciences of the United States of America, 71 9
J. Biaglow, M. Varnes, E. Clark, E. Epp (1983)
The role of thiols in cellular response to radiation and drugs.Radiation research, 95 3
O. Griffith, M. Anderson, A. Meister (1979)
Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase.The Journal of biological chemistry, 254 4
F. Tietze (1969)
Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues.Analytical biochemistry, 27 3
R. Webb (1977)
Lethal and Mutagenic Effects of Near-Ultraviolet Radiation
H. Danpure, R. Tyrrell (1976)
OXYGEN‐DEPENDENCE OF NEAR UV (365 NM) LETHALITY AND THE INTERACTION OF NEAR UV AND X‐RAYS IN TWO MAMMALIAN CELL LINESPhotochemistry and Photobiology, 23
A. Miguel, R. Tyrrell (1983)
Induction of oxygen-dependent lethal damage by monochromatic UVB (313 nm) radiation: strand breakage, repair and cell death.Carcinogenesis, 4 4
P. Cerutti (1985)
Prooxidant states and tumor promotion.Science, 227 4685
P. Smith, M. Paterson (1982)
LETHALITY AND THE INDUCTION AND REPAIR OF DNA DAMAGE IN FAR, MID OR NEAR UV‐IRRADIATED HUMAN FIBROBLASTS: COMPARISON OF EFFECTS IN NORMAL, XERODERMA PIGMENTOSUM AND BLOOM'S SYNDROME CELLSPhotochemistry and Photobiology, 36
Both the UVB (290‐320 nm) and UVA (320‐380 nm) regions of sunlight damage human skin cells but, particularly at the longer wavelengths, information is scant concerning the mechanism(s) of damage induction and the roles of cellular defense mechanisms. Following extensive glutathione depletion of cultured human skin fibroblasts, the cells become strongly sensitized to the cytotoxic action of near‐visible (405 nm), UVA (334 nm, 365 nm) and UVB (313 nm) but not UVC (254 nm) radiations. In the critical UVB region, the magnitude of the protection afforded by endogenous glutathione approaches that of the protection provided by excision repair. The results suggest that a significant fraction of even UVB damage can be mediated by free radical attack and that a major role of glutathione in human skin cells is to protect them from the cytotoxic action of sunlight.
Photochemistry & Photobiology – Wiley
Published: Nov 1, 1986
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