Access the full text.
Sign up today, get DeepDyve free for 14 days.
P. Rottiers, T. Smedt, L. Steidler (2009)
Modulation of Gut-Associated Lymphoid Tissue Functions with Genetically Modified Lactococcus lactisInternational Reviews of Immunology, 28
Shujie Liu, Yongming Li, Ziwei Xu, Yicheng Wang (2010)
Immune responses elicited in mice with recombinant Lactococcus lactis expressing F4 fimbrial adhesin FaeG by oral immunizationVeterinary Research Communications, 34
M. Falagas, G. Betsi, S. Athanasiou (2007)
Probiotics for the treatment of women with bacterial vaginosis.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 13 7
Peter Lee, A. Abdul-Wahid, G. Faubert (2009)
Comparison of the local immune response against Giardia lamblia cyst wall protein 2 induced by recombinant Lactococcus lactis and Streptococcus gordonii.Microbes and infection, 11 1
K. Adachi, K. Kawana, Terufumi Yokoyama, T. Fujii, Ayako Tomio, S. Miura, K. Tomio, S. Kojima, K. Oda, T. Sewaki, T. Yasugi, S. Kōzuma, Y. Taketani (2010)
Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7.Vaccine, 28 16
Tadashi Yoshida, S. Hachimura, S. Kaminogawa (1997)
The oral administration of low-dose antigen induces activation followed by tolerization, while high-dose antigen induces tolerance without activation.Clinical immunology and immunopathology, 82 3
M. Bahey-El-Din, P. Casey, B. Griffin, C. Gahan (2010)
Expression of two Listeria monocytogenes antigens (P60 and LLO) in Lactococcus lactis and examination for use as live vaccine vectors.Journal of medical microbiology, 59 Pt 8
E. Lavelle, D. O’hagan (2006)
Delivery systems and adjuvants for oral vaccinesExpert Opinion on Drug Delivery, 3
B. Rio, R. Dattwyler, M. Aroso, Vera Neves, Luciana Meirelles, J. Seegers, M. Gomes-Solecki (2008)
Oral Immunization with Recombinant Lactobacillus plantarum Induces a Protective Immune Response in Mice with Lyme DiseaseClinical and Vaccine Immunology, 15
J. Wells, L. Loonen, J. Karczewski (2010)
The role of innate signaling in the homeostasis of tolerance and immunity in the intestine.International journal of medical microbiology : IJMM, 300 1
Annick Mercenier, H. Müller-Alouf, C. Grangette (2000)
Lactic acid bacteria as live vaccines.Current issues in molecular biology, 2 1
Jong-Soo Lee, H. Poo, Dong Han, Seung-pyo Hong, Kwang Kim, M. Cho, Eun Kim, M. Sung, Chul-Joong Kim (2006)
Mucosal Immunization with Surface-Displayed Severe Acute Respiratory Syndrome Coronavirus Spike Protein on Lactobacillus casei Induces Neutralizing Antibodies in MiceJournal of Virology, 80
H. Hayashi, R. Takahashi, Takahiro Nishi, M. Sakamoto, Y. Benno (2005)
Molecular analysis of jejunal, ileal, caecal and recto-sigmoidal human colonic microbiota using 16S rRNA gene libraries and terminal restriction fragment length polymorphism.Journal of medical microbiology, 54 Pt 11
H. Cheun, K. Kawamoto, M. Hiramatsu, H. Tamaoki, T. Shirahata, S. Igimi, S. Makino (2004)
Protective immunity of SpaA‐antigen producing Lactococcus lactis against Erysipelothrix rhusiopathiae infectionJournal of Applied Microbiology, 96
K. Inaba (1997)
Dendritic cells as antigen‐presenting cells in vivoImmunology and Cell Biology, 75
J. Chen, J. Field, L. Glickstein, P. Molloy, B. Huber, A. Steere (1999)
Association of antibiotic treatment-resistant Lyme arthritis with T cell responses to dominant epitopes of outer surface protein A of Borrelia burgdorferi.Arthritis and rheumatism, 42 9
M. Neutra, P. Kozlowski (2006)
Mucosal vaccines: the promise and the challengeNature Reviews Immunology, 6
K. Adel‐Patient, S. Ah-Leung, C. Créminon, S. Nouaille, J. Chatel, P. Langella, J. Wal (2005)
Oral administration of recombinant Lactococcus lactis expressing bovine β‐lactoglobulin partially prevents mice from sensitizationClinical & Experimental Allergy, 35
M. Meijerink, S. Hemert, N. Taverne, M. Wels, P. Vos, A. Peter, Bron, H. Savelkoul, J. Bilsen, M. Kleerebezem, J. Wells (2010)
University of Groningen Identification of Genetic Loci in Lactobacillus plantarum That Modulate the Immune Response of Dendritic Cells Using Comparative Genome Hybridization Meijerink,
Xiaowen Liu, L. Lagenaur, D. Simpson, Kirsten Essenmacher, Courtney Frazier-Parker, Yang Liu, Daniel Tsai, Srinivas Rao, D. Hamer, T. Parks, P. Lee, Qiang Xu (2006)
Engineered Vaginal Lactobacillus Strain for Mucosal Delivery of the Human Immunodeficiency Virus Inhibitor Cyanovirin-NAntimicrobial Agents and Chemotherapy, 50
H. Poo, Hyun-Mi Pyo, Tae-Young Lee, Sun-Woo Yoon, Jong-Soo Lee, Chul-Joong Kim, M. Sung, Seung-Hoon Lee (2006)
Oral administration of human papillomavirus type 16 E7 displayed on Lactobacillus casei induces E7‐specific antitumor effects in C57/BL6 miceInternational Journal of Cancer, 119
M. Boyd, K. Gustafson, J. Mcmahon, R. Shoemaker, B. O’Keefe, T. Mori, R. Gulakowski, WU Lin, M. Rivera, C. Laurencot, M. Currens, J. Cardellina, R. Buckheit, P. Nara, L. Pannell, R. Sowder, L. Henderson (1997)
Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide developmentAntimicrobial Agents and Chemotherapy, 41
O. Pusch, D. Boden, S. Hannify, Fred Lee, L. Tucker, M. Boyd, J. Wells, B. Ramratnam (2005)
Bioengineering Lactic Acid Bacteria to Secrete the HIV-1 Virucide CyanovirinJAIDS Journal of Acquired Immune Deficiency Syndromes, 40
C. Grangette, H. Müller-Alouf, P. Hols, D. Goudercourt, J. Delcour, M. Turneer, A. Mercenier (2004)
Enhanced Mucosal Delivery of Antigen with Cell Wall Mutants of Lactic Acid BacteriaInfection and Immunity, 72
Jerry Wells, Karen Robinson, L. Chamberlain, Karin Schofield, R.W.F. Page (1996)
Lactic acid bacteria as vaccine delivery vehiclesAntonie van Leeuwenhoek, 70
P. Ferreira, Ivana Campos, C. Abe, L. Trabulsi, W. Elias, P. Ho, M. Oliveira (2008)
Immunization of mice with Lactobacillus casei expressing intimin fragments produces antibodies able to inhibit the adhesion of enteropathogenic Escherichia coli to cultivated epithelial cells.FEMS immunology and medical microbiology, 54 2
R. Larocque, K. Nakagaki, P. Lee, A. Abdul-Wahid, G. Faubert (2003)
Oral Immunization of BALB/c Mice with Giardia duodenalis Recombinant Cyst Wall Protein Inhibits Shedding of CystsInfection and Immunity, 71
Yi-jing Li, Guang-peng Ma, Guiwei Li, X. Qiao, Jun-wei Ge, Lijie Tang, Min Liu, Li-wei Liu (2010)
Oral Vaccination with the Porcine Rotavirus VP4 Outer Capsid Protein Expressed by Lactococcus lactis Induces Specific Antibody ProductionJournal of Biomedicine and Biotechnology, 2010
K. Xin, Yuka Hoshino, Yoshihiko Toda, S. Igimi, Yoshitsugu Kojima, N. Jounai, K. Ohba, A. Kushiro, M. Kiwaki, K. Hamajima, D. Klinman, K. Okuda (2003)
Immunogenicity and protective efficacy of orally administered recombinant Lactococcus lactis expressing surface-bound HIV Env.Blood, 102 1
P. Norton, Henry Brown, J. Wells, A. Macpherson, P. Wilson, R.W.F. Page (1996)
Factors affecting the immunogenicity of tetanus toxin fragment C expressed in Lactococcus lactis.FEMS immunology and medical microbiology, 14 2-3
M. Mohamadzadeh, T. Duong, S. Sandwick, T. Hoover, T. Klaenhammer (2009)
Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challengeProceedings of the National Academy of Sciences, 106
L. Steidler, K. Robinson, L. Chamberlain, K. Schofield, E. Remaut, R. Page, J. Wells (1998)
Mucosal Delivery of Murine Interleukin-2 (IL-2) and IL-6 by Recombinant Strains of Lactococcus lactis Coexpressing Antigen and CytokineInfection and Immunity, 66
S. Murosaki, Yoshihiro Yamamoto, Kazue Ito, Takeaki Inokuchi, Hiroaki Kusaka, Hitoshi Ikeda, Y. Yoshikai (1998)
Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen-specific IgE production by stimulation of IL-12 production in mice.The Journal of allergy and clinical immunology, 102 1
C. Frossard, L. Steidler, P. Eigenmann (2007)
Oral administration of an IL-10-secreting Lactococcus lactis strain prevents food-induced IgE sensitization.The Journal of allergy and clinical immunology, 119 4
Vesa, Pochart, Marteau (2000)
Pharmacokinetics of Lactobacillus plantarum NCIMB 8826, Lactobacillus fermentum KLD, and Lactococcus lactis MG 1363 in the human gastrointestinal tractAlimentary Pharmacology & Therapeutics, 14
L. Bermúdez-Humarán, N. Cortes-Perez, Y. Loir, J. Alcocer-González, R. Tamez-Guerra, R. Oca-Luna, P. Langella (2004)
An inducible surface presentation system improves cellular immunity against human papillomavirus type 16 E7 antigen in mice after nasal administration with recombinant lactococci.Journal of medical microbiology, 53 Pt 5
S. Hanniffy, A. Carter, E. Hitchin, J. Wells (2007)
Mucosal delivery of a pneumococcal vaccine using Lactococcus lactis affords protection against respiratory infection.The Journal of infectious diseases, 195 2
J. Chatel, S. Nouaille, K. Adel‐Patient, Y. Loir, H. Boe, A. Gruss, J. Wal, P. Langella (2003)
Characterization of a Lactococcus lactis Strain That Secretes a Major Epitope of Bovine Beta-Lactoglobulin and Evaluation of Its Immunogenicity in MiceApplied and Environmental Microbiology, 69
S. Innocentin, V. Guimarães, A. Miyoshi, V. Azevedo, P. Langella, J. Chatel, F. Lefèvre (2009)
Lactococcus lactis Expressing either Staphylococcus aureus Fibronectin-Binding Protein A or Listeria monocytogenes Internalin A Can Efficiently Internalize and Deliver DNA in Human Epithelial CellsApplied and Environmental Microbiology, 75
Bernard Quigley, Matthew Hatkoff, D. Thanassi, Mahamoudou Ouattara, Z. Eichenbaum, J. Scott (2009)
A Foreign Protein Incorporated on the Tip of T3 Pili in Lactococcus lactis Elicits Systemic and Mucosal ImmunityInfection and Immunity, 78
Peter Lee, G. Faubert (2006)
Oral immunization of BALB/c mice by intragastric delivery of Streptococcus gordonii-expressing Giardia cyst wall protein 2 decreases cyst shedding in challenged mice.FEMS microbiology letters, 265 2
N. Cortes-Perez, L. Medina, F. Lefèvre, P. Langella, L. Bermúdez-Humarán (2008)
Production of biologically active CXC chemokines by Lactococcus lactis: evaluation of its potential as a novel mucosal vaccine adjuvant.Vaccine, 26 46
I. Huibregtse, E. Marietta, Shadi Rashtak, F. Koning, P. Rottiers, Chella David, Sander Deventer, Joseph Murray (2009)
Induction of Antigen-Specific Tolerance by Oral Administration of Lactococcus lactis Delivered Immunodominant DQ8-Restricted Gliadin Peptide in Sensitized Nonobese Diabetic Ab° Dq8 Transgenic Mice1The Journal of Immunology, 183
E. Vaughan, M. Vries, E. Zoetendal, K. Ben-Amor, A. Akkermans, W. Vos (2002)
The Intestinal LABsAntonie van Leeuwenhoek, 82
K. Vandenbroucke, W. Hans, J. Huysse, S. Neirynck, P. Demetter, E. Remaut, P. Rottiers, L. Steidler (2004)
Active delivery of trefoil factors by genetically modified Lactococcus lactis prevents and heals acute colitis in mice.Gastroenterology, 127 2
A. Repa, C. Grangette, C. Daniel, R. Hochreiter, K. Hoffmann‐Sommergruber, J. Thalhamer, D. Kraft, H. Breiteneder, A. Mercenier, U. Wiedermann (2003)
Mucosal co-application of lactic acid bacteria and allergen induces counter-regulatory immune responses in a murine model of birch pollen allergy.Vaccine, 22 1
Masafumi Yamamoto, Masafumi Yamamoto, Jerry McGhee, Y. Hagiwara, Shigeo Otake, Hiroshi Kiyono, Hiroshi Kiyono (2001)
Genetically Manipulated Bacterial Toxin as a New Generation Mucosal AdjuvantScandinavian Journal of Immunology, 53
D. Levin, Stephanie Constant, T. Pasqualini, R. Flavell, K. Bottomly (1993)
Role of dendritic cells in the priming of CD4+ T lymphocytes to peptide antigen in vivo.Journal of immunology, 151 12
L. Erdile, M. Brandt, Donald Warakomski, Gary Westrack, A. Sadziene, A. Barbour, John MAYSl (1993)
Role of attached lipid in immunogenicity of Borrelia burgdorferi OspAInfection and Immunity, 61
C. Grangette, H. Müller-Alouf, M. Geoffroy, D. Goudercourt, M. Turneer, A. Mercenier (2002)
Protection against tetanus toxin after intragastric administration of two recombinant lactic acid bacteria: impact of strain viability and in vivo persistence.Vaccine, 20 27-28
V. Guimarães, S. Innocentin, F. Lefèvre, V. Azevedo, J. Wal, P. Langella, J. Chatel (2006)
Use of Native Lactococci as Vehicles for Delivery of DNA into Mammalian Epithelial CellsApplied and Environmental Microbiology, 72
Hyuk Chu, Seungha Kang, S. Ha, Kwan-Hyun Cho, Sung-Moo Park, K. Han, S. Kang, Honggu Lee, S. Han, C. Yun, Yunjaie Choi (2005)
Lactobacillus acidophilus Expressing Recombinant K99 Adhesive Fimbriae Has an Inhibitory Effect on Adhesion of Enterotoxigenic Escherichia coliMicrobiology and Immunology, 49
E. Marietta, K. Black, M. Camilleri, P. Krause, R. Rogers, C. David, M. Pittelkow, J. Murray (2004)
A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice.The Journal of clinical investigation, 114 8
Catherine Daniel, A. Repa, A. Mercenier, U. Wiedermann, J. Wells (2007)
The European LABDEL project and its relevance to the prevention and treatment of allergiesAllergy, 62
Song Lee (2003)
Oral colonization and immune responses to Streptococcus gordonii: potential use as a vector to induce antibodies against respiratory pathogensCurrent Opinion in Infectious Diseases, 16
C. Beninati, M. Oggioni, M. Boccanera, M. Spinosa, T. Maggi, S. Conti, W. Magliani, F. Bernardis, G. Teti, Antonio Cassone, G. Pozzi, L. Polonelli (2000)
Therapy of mucosal candidiasis by expression of an anti-idiotype in human commensal bacteriaNature Biotechnology, 18
X. Qiao, Guiwei Li, Xiangqing Wang, Xiaojing Li, Min Liu, Yi-jing Li (2009)
Recombinant porcine rotavirus VP4 and VP4-LTB expressed in Lactobacillus casei induced mucosal and systemic antibody responses in miceBMC Microbiology, 9
Srinivas Rao, Stella Hu, L. McHugh, K. Lueders, K. Henry, Qi Zhao, R. Fekete, S. Kar, S. Adhya, D. Hamer (2005)
Toward a live microbial microbicide for HIV: commensal bacteria secreting an HIV fusion inhibitor peptide.Proceedings of the National Academy of Sciences of the United States of America, 102 34
C. Daniel, F. Sebbane, S. Poiret, D. Goudercourt, J. Dewulf, C. Mullet, M. Simonet, B. Pot (2009)
Protection against Yersinia pseudotuberculosis infection conferred by a Lactococcus lactis mucosal delivery vector secreting LcrV.Vaccine, 27 8
Ivana Campos, M. Darrieux, D. Ferreira, E. Miyaji, Débora Silva, A. Arêas, K. Aires, L. Leite, P. Ho, M. Oliveira (2008)
Nasal immunization of mice with Lactobacillus casei expressing the Pneumococcal Surface Protein A: induction of antibodies, complement deposition and partial protection against Streptococcus pneumoniae challenge.Microbes and infection, 10 5
W. Jechlinger (2006)
Optimization and delivery of plasmid DNA for vaccinationExpert Review of Vaccines, 5
A. Kruisselbrink, M. Bak-Glashouwer, C. Havenith, J. Thole, R. Janssen (2001)
Recombinant Lactobacillus plantarum inhibits house dust mite‐specific T‐cell responsesClinical & Experimental Immunology, 126
C. Grangette, H. Müller-Alouf, D. Goudercourt, M. Geoffroy, M. Turneer, A. Mercenier (2001)
Mucosal Immune Responses and Protection against Tetanus Toxin after Intranasal Immunization with RecombinantLactobacillus plantarumInfection and Immunity, 69
P. Mannam, Kevin Jones, B. Geller (2004)
Mucosal Vaccine Made from Live, Recombinant Lactococcus lactis Protects Mice against Pharyngeal Infection with Streptococcus pyogenesInfection and Immunity, 72
L. Bermúdez-Humarán, N. Cortes-Perez, F. Lefèvre, V. Guimarães, S. Rabot, J. Alcocer-González, J. Gratadoux, C. Rodríguez-Padilla, R. Tamez-Guerra, G. Corthier, A. Gruss, P. Langella (2005)
A Novel Mucosal Vaccine Based on Live Lactococci Expressing E7 Antigen and IL-12 Induces Systemic and Mucosal Immune Responses and Protects Mice against Human Papillomavirus Type 16-Induced TumorsThe Journal of Immunology, 175
T. Kraus, L. Mayer (2005)
Oral tolerance and inflammatory bowel diseaseCurrent Opinion in Gastroenterology, 21
H. Wu, H. Weiner (2003)
Oral toleranceImmunologic Research, 28
L. Steidler (2002)
In situ delivery of cytokines by genetically engineered Lactococcus lactisAntonie van Leeuwenhoek, 82
N. Novak, J. Allam, H. Betten, J. Haberstok, T. Bieber (2004)
The role of antigen presenting cells at distinct anatomic sites: they accelerate and they slow down allergiesAllergy, 59
D. Shaw, B. Gaerthé, R. Leer, J. Stap, C. Smittenaar, M. Bak-Glashouwer, J. Thole, F. Tielen, P. Pouwels, C. Havenith (2000)
Engineering the microflora to vaccinate the mucosa: serum immunoglobulin G responses and activated draining cervical lymph nodes following mucosal application of tetanus toxin fragment C‐expressing lactobacilliImmunology, 100
Barbara Giomarelli, R. Provvedi, F. Meacci, T. Maggi, D. Medaglini, G. Pozzi, Toshiyuki Mori, J. Mcmahon, R. Gardella, M. Boyd (2002)
The microbicide cyanovirin-N expressed on the surface of commensal bacterium Streptococcus gordonii captures HIV-1AIDS, 16
B. Rio, J. Seegers, M. Gomes-Solecki (2010)
Immune Response to Lactobacillus plantarum Expressing Borrelia burgdorferi OspA Is Modulated by the Lipid Modification of the AntigenPLoS ONE, 5
M. Bahey-El-Din, P. Casey, B. Griffin, C. Gahan (2008)
Lactococcus lactis-expressing listeriolysin O (LLO) provides protection and specific CD8+ T cells against Listeria monocytogenes in the murine infection modelVaccine, 26
Y. Charng, Ching-Chi Lin, Ching‐Hsiang Hsu (2006)
Inhibition of allergen-induced airway inflammation and hyperreactivity by recombinant lactic-acid bacteria.Vaccine, 24 33-34
Su-jung Kim, J. Lee, D. Jun, J. Song, Woo-Kon Lee, M. Cho, Y. Kim (2009)
Oral administration of Lactococcus lactis expressing Helicobacter pylori Cag7‐ct383 protein induces systemic anti‐Cag7 immune response in miceFems Immunology and Medical Microbiology, 57
Carlos Perez, C. Eichwald, O. Burrone, D. Mendoza (2005)
Rotavirus vp7 antigen produced by Lactococcus lactis induces neutralizing antibodies in miceJournal of Applied Microbiology, 99
Zhi-hong Zhang, P. Jiang, Ning-Jun Li, M. Shi, W. Huang (2005)
Oral vaccination of mice against rodent malaria with recombinant Lactococcus lactis expressing MSP-1(19).World journal of gastroenterology, 11 44
N. Cortes-Perez, Pascale Kharrat, P. Langella, L. Bermúdez-Humarán (2009)
Heterologous production of human papillomavirus type-16 L1 protein by a lactic acid bacteriumBMC Research Notes, 2
C. Krüger, Yanzhong Hu, Q. Pan, H. Marcotte, A. Hultberg, Dipu Delwar, P. Dalen, P. Pouwels, R. Leer, C. Kelly, C. Dollenweerd, J. Ma, L. Hammarström (2002)
In situ delivery of passive immunity by lactobacilli producing single-chain antibodiesNature Biotechnology, 20
K. Robinson, L. Chamberlain, K. Schofield, J. Wells, R. Page (1997)
Oral vaccination of mice against tetanus with recombinant Lactococcus lactisNature Biotechnology, 15
C. Gilbert, K. Robinson, R. Page, J. Wells (2000)
Heterologous Expression of an Immunogenic Pneumococcal Type 3 Capsular Polysaccharide in Lactococcus lactisInfection and Immunity, 68
Chang-yi Wu, Guang Yang, L. Bermúdez-Humarán, Qing-feng Pang, Yin-ming Zeng, Junke Wang, Xin-yue Gao (2006)
Immunomodulatory effects of IL-12 secreted by Lactococcus lactis on Th1/Th2 balance in ovalbumin (OVA)-induced asthma model mice.International immunopharmacology, 6 4
Yungang Li, F. Tian, Feng-shan Gao, Xiu-Shan Tang, C. Xia (2007)
Immune responses generated by Lactobacillus as a carrier in DNA immunization against foot-and-mouth disease virus.Vaccine, 25 5
P. Norton, J. Wells, H. Brown, A. Macpherson, R. Page (1997)
Protection against tetanus toxin in mice nasally immunized with recombinant Lactococcus lactis expressing tetanus toxin fragment C.Vaccine, 15 6-7
Theresa Chang, Chia-Hwa Chang, D. Simpson, Qiang Xu, Patrick Martin, L. Lagenaur, G. Schoolnik, D. Ho, S. Hillier, M. Holodniy, J. Lewicki, P. Lee (2003)
Inhibition of HIV infectivity by a natural human isolate of Lactobacillus jensenii engineered to express functional two-domain CD4Proceedings of the National Academy of Sciences of the United States of America, 100
X. Yigang, L. Yijing (2008)
Construction of recombinant Lactobacillus casei efficiently surface displayed and secreted porcine parvovirus VP2 protein and comparison of the immune responses induced by oral immunizationImmunology, 124
D. Pontes, F. Dorella, L. Ribeiro, A. Miyoshi, Y. Loir, A. Gruss, S. Oliveira, P. Langella, V. Azevedo (2003)
Induction of Partial Protection in Mice after Oral Administration of Lactococcus lactis Producing Brucella abortus L7/L12 AntigenJournal of Drug Targeting, 11
H. Chakraborty, P. Sen, R. Helms, P. Vernazza, S. Fiscus, J. Eron, B. Patterson, R. Coombs, J. Krieger, M. Cohen (2001)
Viral burden in genital secretions determines male-to-female sexual transmission of HIV-1: a probabilistic empiric modelAIDS, 15
V. Guimarães, J. Gabriel, F. Lefèvre, D. Cabanes, A. Gruss, P. Cossart, V. Azevedo, P. Langella (2005)
Internalin-expressing Lactococcus lactis is able to invade small intestine of guinea pigs and deliver DNA into mammalian epithelial cells.Microbes and infection, 7 5-6
J. Wells, O. Rossi, M. Meijerink, Peter Baarlen (2010)
Epithelial crosstalk at the microbiota–mucosal interfaceProceedings of the National Academy of Sciences, 108
Daniela Ferreira, M. Darrieux, D. Silva, Luciana Leite, Jorge Ferreira, Paulo Ho, E. Miyaji, M. Oliveira (2009)
Characterization of Protective Mucosal and Systemic Immune Responses Elicited by Pneumococcal Surface Protein PspA and PspC Nasal Vaccines against a Respiratory Pneumococcal Challenge in MiceClinical and Vaccine Immunology, 16
B. Foligné, R. Dessein, M. Marceau, S. Poiret, M. Chamaillard, B. Pot, M. Simonet, C. Daniel (2007)
Prevention and treatment of colitis with Lactococcus lactis secreting the immunomodulatory Yersinia LcrV protein.Gastroenterology, 133 3
M. Oliveira, A. Arêas, Ivana Campos, V. Monedero, G. Pérez-Martínez, E. Miyaji, L. Leite, K. Aires, Paulo Ho (2006)
Induction of systemic and mucosal immune response and decrease in Streptococcus pneumoniae colonization by nasal inoculation of mice with recombinant lactic acid bacteria expressing pneumococcal surface antigen AMicrobes and Infection, 8
J. Wells, A. Mercenier (2008)
Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteriaNature Reviews. Microbiology, 6
M. Johansson, M. Phillipson, J. Petersson, A. Velcich, L. Holm, G. Hansson (2008)
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteriaProceedings of the National Academy of Sciences, 105
L. Steidler, J. Wells, A. Raeymaekers, J. Vandekerckhove, W. Fiers, E. Remaut (1995)
Secretion of biologically active murine interleukin-2 by Lactococcus lactis subsp. lactisApplied and Environmental Microbiology, 61
L. Steidler, W. Hans, Lieven Schotte, S. Neirynck, F. Obermeier, W. Falk, W. Fiers, E. Remaut (2000)
Treatment of murine colitis by Lactococcus lactis secreting interleukin-10.Science, 289 5483
B. Corthésy, S. Boris, P. Isler, C. Grangette, A. Mercenier (2005)
Oral immunization of mice with lactic acid bacteria producing Helicobacter pylori urease B subunit partially protects against challenge with Helicobacter felis.The Journal of infectious diseases, 192 8
Y. Dièye, A. Hoekman, Florence Clier, V. Juillard, H. Boot, J. Piard (2003)
Ability of Lactococcus lactis To Export Viral Capsid Antigens: a Crucial Step for Development of Live VaccinesApplied and Environmental Microbiology, 69
C. Chancey, K. Khanna, J. Seegers, Guang-wen Zhang, James Hildreth, Abigail Langan, R. Markham (2006)
Lactobacilli-Expressed Single-Chain Variable Fragment (scFv) Specific for Intercellular Adhesion Molecule 1 (ICAM-1) Blocks Cell-Associated HIV-1 Transmission across a Cervical Epithelial Monolayer1The Journal of Immunology, 176
C. Tacket, M. Levine (2007)
CVD 908, CVD 908-htrA, and CVD 909 live oral typhoid vaccines: a logical progression.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 45 Suppl 1
Akinobu Kajikawa, K. Masuda, M. Katoh, S. Igimi (2009)
Adjuvant Effects for Oral Immunization Provided by Recombinant Lactobacillus casei Secreting Biologically Active Murine Interleukin-1βClinical and Vaccine Immunology, 17
M. Rescigno, G. Rotta, B. Valzasina, P. Ricciardi-Castagnoli (2001)
Dendritic cells shuttle microbes across gut epithelial monolayers.Immunobiology, 204 5
S. Holgate (1999)
The epidemic of allergy and asthmaNature, 402
J. Wells, P. Wilson, R. Page (1993)
Improved cloning vectors and transformation procedure for Lactococcus lactis.The Journal of applied bacteriology, 74 6
Akinobu Kajikawa, E. Satoh, R. Leer, Shigeki Yamamoto, S. Igimi (2007)
Intragastric immunization with recombinant Lactobacillus casei expressing flagellar antigen confers antibody-independent protective immunity against Salmonella enterica serovar EnteritidisVaccine, 25
A. Friedman, H. Weiner (1994)
Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.Proceedings of the National Academy of Sciences of the United States of America, 91 14
Lijie Tang, Yi-jing Li (2009)
Oral immunization of mice with recombinant Lactococcus lactis expressing porcine transmissible gastroenteritis virus spike glycoproteinVirus Genes, 39
Ho-Keun Kwon, Choong-Gu Lee, Jae-Seon So, Chang-Suk Chae, Ji-sun Hwang, Anupama Sahoo, J. Nam, J. Rhee, K. Hwang, S. Im (2010)
Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disordersProceedings of the National Academy of Sciences, 107
Jiankui Liu, Xi-Lin Hou, Chunhua Wei, Li-yun Yu, Xiao-jie He, Gui-hua Wang, Jong-Soo Lee, Chul-Joong Kim (2009)
Induction of Immune Responses in Mice after Oral Immunization with Recombinant Lactobacillus casei Strains Expressing Enterotoxigenic Escherichia coli F41 Fimbrial ProteinApplied and Environmental Microbiology, 75
I. Huibregtse, V. Snoeck, A. Creus, H. Braat, Ester Jong, S. Deventer, P. Rottiers (2007)
Induction of ovalbumin-specific tolerance by oral administration of Lactococcus lactis secreting ovalbumin.Gastroenterology, 133 2
N. Klijn, A. Weerkamp, M. Willem, De, Vos (1995)
Genetic marking of Lactococcus lactis shows its survival in the human gastrointestinal tractApplied and Environmental Microbiology, 61
Catherine Daniel, Andreas Repa, C. Wild, Arnold Pollak, Bruno Pot, H. Breiteneder, Ursula Wiedermann, Annick Mercenier (2006)
Modulation of allergic immune responses by mucosal application of recombinant lactic acid bacteria producing the major birch pollen allergen Bet v 1Allergy, 61
H. Weiner (2004)
Current Issues in the Treatment of Human Diseases by Mucosal ToleranceAnnals of the New York Academy of Sciences, 1029
H. Braat, P. Rottiers, D. Hommes, N. Huyghebaert, E. Remaut, J. Remon, S. Deventer, S. Neirynck, M. Peppelenbosch, L. Steidler (2006)
A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 4 6
Karen Robinson, L. Chamberlain, M. López, Catherine Rush, H. Marcotte, R.W.F. Page, Jerry Wells (2004)
Mucosal and Cellular Immune Responses Elicited by Recombinant Lactococcus lactis Strains Expressing Tetanus Toxin Fragment CInfection and Immunity, 72
L. Waaij, H. Harmsen, M. Madjipour, F. Kroese, M. Zwiers, H. Dullemen, N. Boer, G. Welling, P. Jansen (2005)
Bacterial Population Analysis of Human Colon and Terminal Ileum Biopsies with 16S rRNA‐based Fluorescent Probes: Commensal Bacteria Live in Suspension and Have No Direct Contact with Epithelial CellsInflammatory Bowel Diseases, 11
D. Wolvers, J. Antoine, E. Myllyluoma, J. Schrezenmeir, H. Szajewska, G. Rijkers (2010)
Guidance for substantiating the evidence for beneficial effects of probiotics: prevention and management of infections by probiotics.The Journal of nutrition, 140 3
O. Pusch, Roopa Kalyanaraman, L. Tucker, J. Wells, B. Ramratnam, D. Boden (2006)
An anti-HIV microbicide engineered in commensal bacteria: secretion of HIV-1 fusion inhibitors by lactobacilliAIDS, 20
Scilla Buccato, D. Maione, C. Rinaudo, G. Volpini, A. Taddei, R. Rosini, J. Telford, G. Grandi, I. Margarit (2006)
Use of Lactococcus lactis expressing pili from group B Streptococcus as a broad-coverage vaccine against streptococcal disease.The Journal of infectious diseases, 194 3
L. Hanson (1959)
Comparative analysis of human milk and human blood plasma by means of diffusion-in-gel methodsExperientia, 15
H. Christensen, H. Frøkiær, J. Pestka (2002)
Lactobacilli Differentially Modulate Expression of Cytokines and Maturation Surface Markers in Murine Dendritic Cells1The Journal of Immunology, 168
Lactic acid bacteria (LAB) have proved to be effective mucosal delivery vehicles that overcome the problem of delivering functional proteins to the mucosal tissues. By the intranasal route, both live and killed LAB vaccine strains have been shown to elicit mucosal and systemic immune responses that afford protection against infectious challenges. To be effective via oral administration, frequent dosing over several weeks is required but new targeting and adjuvant strategies have clearly demonstrated the potential to increase the immunogenicity and protective immunity of LAB vaccines. Oral administration of Lactococcus lactis has been shown to induce antigen-specific oral tolerance (OT) to secreted recombinant antigens. LAB delivery is more efficient at inducing OT than the purified antigen, thus avoiding the need for purification of large quantities of antigen. This approach holds promise for new therapeutic interventions in allergies and antigen-induced autoimmune diseases. Several clinical and research reports demonstrate considerable progress in the application of genetically modified L. lactis for the treatment of inflammatory bowel disease (IBD). New medical targets are on the horizon, and the approval by several health authorities and biosafety committees of a containment system for a genetically modified L. lactis that secretes Il-10 should pave the way for new LAB delivery applications in the future.
Annual Review of Food Science and Technology – Annual Reviews
Published: Apr 10, 2011
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.