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1 The influence of the thromboxane A2‐mimetic U46619 (11α,9α‐epoxymethano PGH2) on 5‐hydroxytryptamine (5‐HT)‐induced contractions of the rabbit isolated femoral artery has been examined. 2 In the absence of U46619, 5‐HT responses were mediated predominantly by 5‐HT2‐receptors as judged by potent, surmountable antagonism by the selective 5‐HT2 receptor antagonists, spiperone and ketanserin. Both antagonists unmasked a population of 5‐HT1‐like receptors which accounted for approximately 10–15% of the 5‐HT maximum response. 3 In the presence of U46619 (3–10 nm), 5‐HT‐induced contractions were largely resistant to blockade by 5‐HT2 receptor antagonists since 5‐HT1‐like receptor‐mediated contraction now accounted for approximately 60% of the 5‐HT maximum response. 4 These results show that activation of thromboxane A2 receptors in a tissue possessing both 5‐HT2 and 5‐HT1‐like receptors can convert 5‐HT‐induced contraction from one mediated predominantly by 5‐HT2 receptors to one which is mediated predominantly by 5‐HT1‐like receptors.
British Journal of Pharmacology – Wiley
Published: Oct 1, 1992
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