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Linda Waters, R. Pearl, R. Macaulay (1989)
A comparative analysis of the ability of five classes of pharmacological agents to augment skin flap survival in various models and species: an attempt to standardize skin flap research.Annals of Plastic Surgery, 23
C. Mogelvang (1995)
Emotion, illogic, and familial breast cancer.Plastic and reconstructive surgery, 95 4
L. Zachary, J. Heggers, M. Robson, R. Murphy (1986)
Combined Prostacyclin and Thromboxane Synthetase Inhibitor UK 38485 in Flap SurvivalAnnals of Plastic Surgery, 17
Frey Frey
Zur Therapie der PankreatitisTherapiewoche, 4
G. Godcu, M. Beertrand, M. Fléron, E. Barré, J. Baron, P. Coriat, E. Kicffer, P. Viars (1992)
APROTININ DECREASES PERIOPERATIVE BLEEDING AND BLOOD PRODUCT REQUIREMENT DURING THORACIC AORTIC SURGERY PERFORMED WITH EXTRACORPOREAL CIRCULATIONAnesthesiology, 77
H. Kraut, E. Frey, E. Werle
Über die Inaktivierung des Kallikreins. (VI. Mitteilung über dieses Kreislaufhormon.)Biological Chemistry, 192
W. Dietrich, A. Barankay, Ch. Hähnel, J. Richter (1992)
High-dose aprotinin in cardiac surgery: three years' experience in 1,784 patients.Journal of cardiothoracic and vascular anesthesia, 6 3
B. Douglas, H. Weinberg, Y. Song, D. Silverman (1987)
Beneficial effects of ibuprofen on experimental microvascular free flaps: pharmacologic alteration of the no-reflow phenomenon.Plastic and reconstructive surgery, 79 3
J. Thompson, O. Roath, J. Francis, J. Webster, A. Chant (1990)
Aprotinin in peripheral vascular surgeryThe Lancet, 335
Brian Cooley, D. Hanel, R. Anderson, M. Foster, J. Gould (1992)
The Influence of Diabetes on Free Flap Transfer: I. Flap Survival and Microvascular HealingAnnals of Plastic Surgery, 29
C. Kerrigan, M. Stotland (1993)
Ischemia reperfusion injury: A reviewMicrosurgery, 14
Gurevitch Gurevitch, Barak Barak, Paz Paz, Yakirevich Yakirevich (1994)
Aprotinin improves myocardial recovery after ischemia and reperfusionJ Thoracic Cardiovasc Surg, 108
U. Rajagopal, R. Friedman, J. Robinson, Rod Rohrich (1995)
Iloprost enhances survival of axial-pattern skin flaps in an ischemia-reperfusion model.Plastic and reconstructive surgery, 95 5
L. Bucky, N. Vedder, H. Hong, H. Ehrlich, R. Winn, J. Harlan, J. May (1994)
Reduction of Burn Injury by Inhibiting CD18‐Mediated Leukocyte Adherence in RabbitsPlastic and Reconstructive Surgery, 93
F. Finseth, M. Adelberg (1978)
PREVENTION OF SKIN FLAP NECROSIS BY A COURSE OF TREATMENT WITH VASODILATOR DRUGSPlastic and Reconstructive Surgery, 61
J. May, L. Chait, B. O'brien, J. Hurley (1978)
THE NO‐REFLOW PHENOMENON IN EXPERIMENTAL FREE FLAPSPlastic and Reconstructive Surgery, 61
R. Dolan, Donald Kerr, T. Schneiderman, S. Arena (1995)
Reducing Ischemia‐Reperfusion Injury in Rat Island Groin Flaps Using DexamethasoneAnnals of Plastic Surgery, 35
E. Eriksson, R. Straube, M. Robson (1979)
White blood cell consumption in the microcirculation after a major burn.The Journal of trauma, 19 2
P. Werker, Moshe Kon, Colin Green, R. Franken, M. Overgoor (1993)
Neither desferrioxamine nor lipoic acid enhances the cold ischaemic tolerance of epigastric free flaps in ratsMicrosurgery, 14
Hallett Hallett, Shandall Shandall, Young Young (1985)
Mechanism of protection against “reperfusion injury” by aprotininBiochem Pharmacol, 34
M. Hallett, A. Shandall, H. Young (1985)
Mechanism of protection against "reperfusion injury" by aprotinin. Roles of polymorphonuclear leucocytes and oxygen radicals.Biochemical pharmacology, 34 10
S. Weiss (1989)
Tissue destruction by neutrophils.The New England journal of medicine, 320 6
B. Bidstrup, D. Royston, R. Sapsford, K. Taylor, D. Cosgrove (1989)
Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol).The Journal of thoracic and cardiovascular surgery, 97 3
H. Fritz, J. Kruck, I. Rüsse, H. Liebich (1979)
Immunofluorescence studies indicate that the basic trypsin-kallikrein-inhibitor of bovine organs (Trasylol) originates from mast cells.Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 360 3
P. Neuhaus, W. Bechstein, B. Lefèbre, G. Blumhardt, K. Slama (1989)
EFFECT OF APROTININ ON INTRAOPERATIVE BLEEDING AND FIBRINOLYSIS IN LIVER TRANSPLANTATIONThe Lancet, 334
C. Pang, C. Forrest, S. Morris (1989)
Pharmacological Augmentation of Skin Flap Viability: A Hypothesis to Mimic the Surgical Delay Phenomenon or a Wishful ThoughtAnnals of Plastic Surgery, 22
Brian Cooley, J. Gould (1993)
Influence of Age on Free Flap Tolerance to Ischemia: An Experimental Study in RatsAnnals of Plastic Surgery, 30
Emad Bukhari, I. Krukenkamp, Paul Burns, Glenn Gaudette, Joshua Schulman, Mohammed Al-Fagih, Sidney Levitsky (1995)
Does aprotinin increase the myocardial damage in the setting of ischemia and preconditioning?The Annals of thoracic surgery, 60 2
R. Franken, P. Werker, M. Overgoor, M. Kon (1993)
Non‐revascularized epigastric free flap: No all‐or‐none survival patternMicrosurgery, 14
J. Gurevitch, J. Barak, H. Miller, A. Kramer, Y. Paz, V. Yakirevich (1994)
Conjoined double internal mammary artery grafting.Scandinavian journal of thoracic and cardiovascular surgery, 28 3-4
C. Mellow, K. Knight, M. Angel, B. O'brien (1990)
The Effect of Thromboxane Synthetase Inhibition on Tolerance of Skin Flaps to Secondary Ischemia Caused by Venous ObstructionPlastic and Reconstructive Surgery, 86
D. Royston (1992)
High-dose aprotinin therapy: a review of the first five years' experience.Journal of cardiothoracic and vascular anesthesia, 6 1
F. Finseth, C. Cutting (1978)
AN EXPERIMENTAL NEUROVASCULAR ISLAND SKIN FLAP FOR THE STUDY OF THE DELAY PHENOMENONPlastic and Reconstructive Surgery, 61
M. Janssens, J. Joris, J. David, R. Lemaire, M. Lamy (1994)
High‐dose Aprotinin Reduces Blood Loss in Patients Undergoing Total Hip Replacement SurgeryAnesthesiology, 80
W. Reus, R. Murphy, J. Heggers, M. Robson, R. McCauley (1984)
Effect of Intraarterial Prostacyclin on Survival of Skin Flaps in the Pig: Biphasic ResponseAnnals of Plastic Surgery, 13
P. Bradley, D. Priebat, R. Christensen, G. Rothstein (1982)
Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker.The Journal of investigative dermatology, 78 3
S. Westaby (1993)
Aprotinin in perspective.The Annals of thoracic surgery, 55 4
I. Sultan, M. Sunamori, A. Suzuki (1992)
Heart preservation: analysis of cardioprotective infusate characteristics. Membrane stabilization, calcium antagonism, and protease inhibition on myocardial viability: a biochemical, ultrastructural, functional study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 11 4 Pt 1
Kraut Kraut, Frey Frey, Werle Werle (1930)
Über die Inaktiverung des KallikreinsHoppe‐Seyler's Zeitschrift für Physiologische Chemie., 192
Angel Mf, C. Mellow, K. Knight, B. O'brien (1989)
The effect of time of vascular island skin flap elevation on tolerance to warm ischemia.Annals of Plastic Surgery, 22
C. Kerrigan, R. Daniel (1982)
Pharmacologic Treatment of the Failing Skin FlapPlastic and Reconstructive Surgery, 70
R. Rees, D. Smith, T. Li, B. Cashmer, W. Garner, J. Punch, D. Smith (1994)
The role of xanthine oxidase and xanthine dehydrogenase in skin ischemia.The Journal of surgical research, 56 2
M. Angel, S. Ramasastry, W. Swartz, R. Basford, J. Futrell (1987)
Free radicals: basic concepts concerning their chemistry, pathophysiology, and relevance to plastic surgery.Plastic and reconstructive surgery, 79 6
R. Kono, K. Miyamura, T. Ogino, N. Wadia, P. Wadia, S. Katrak, V. Misra (1981)
Antibody titres to enterovirus type 70 in the 1981 Indian epidemic of acute haemorrhagic conjunctivitis.Lancet, 2 8252
R. Rees, J. Punch, K. Shaheen, B. Cashmer, K. Guice, David Smith (1993)
The Stress Response in Skin: The Role of Neutrophil Products in PreconditioningPlastic and Reconstructive Surgery, 92
Angel Angel, Knight Knight, Mellow Mellow (1989)
The effect of prior elevation of skin flaps and ischemia on blood thromboxane levelsAnn Plast Surg, 22
O. Çetinkale, L. Bilgic, F. Ayan, A. Kandilci (1996)
Neutrophil‐Mediated Injury in Ischemic Skin Flaps: Amelioration of Ischemic Injury by Cyclosporine in the RatAnnals of Plastic Surgery, 37
Fritz Fritz, Wunderer Wunderer (1983)
Biochemistry and applications of aprotinin, the kallikrein inhibitor from bovine organsArzneim Forsch, 33
Wayne Stadelmann, D. Greenwald, L. Stevens, Scott Shumway, Karen Leoni, T. Krizek (1993)
Mechanical analysis of the effects of bacteria and aprotinin on skin wound healing in adult guinea pigsWound Repair and Regeneration, 1
R. Dunn, John Mancoll (1992)
Flap models in the rat: a review and reappraisal.Plastic and reconstructive surgery, 90 2
M. D’Ambra, C. Akins, E. Blackstone, Sharon Bonney, L. Cohn, D. Cosgrove, J. Levy, K. Lynch, R. Maddi (1996)
Aprotinin in primary valve replacement and reconstruction: a multicenter, double-blind, placebo-controlled trial.The Journal of thoracic and cardiovascular surgery, 112 4
R. Lord, O. Roath, J. Thompson, A. Chant, J. Francis (1992)
Effect of aprotinin on neutrophil function after major vascular surgeryBritish Journal of Surgery, 79
T. Shanley, R. Warner, P. Ward (1995)
The role of cytokines and adhesion molecules in the development of inflammatory injury.Molecular medicine today, 1 1
H. Weinberg, Wen Zhang, M. Urken (1993)
Uw solution as an experimental microvascular skin flap perfusateMicrosurgery, 14
M. Im, W. Shen, Chun Pak, P. Manson, G. Bulkley, J. Hoopes (1984)
Effect of Allopurinol on the Survival of Hyperemic Island Skin FlapsPlastic and Reconstructive Surgery, 73
Stadelmann Stadelmann, Greenwald Greenwald, Stevens Stevens, Shumway Shumway, Leoni Leoni, Krizek Krizek (1993)
Effects of bacteria on skin wound healing are reversed by TrasylolJ Wound Healing Regen, 1
N. Vedder, L. Bucky, Nancy Richey, R. Winn, J. May (1994)
Improved Survival Rates of Random Flaps in Rabbits with a Monoclonal Antibody That Blocks Leukocyte AdherencePlastic and Reconstructive Surgery, 93
N. Hayashida, T. Isomura, T. Sato, H. Maruyama, K. Kosuga, S. Aoyagi (1997)
Effects of minimal-dose aprotinin on coronary artery bypass grafting.The Journal of thoracic and cardiovascular surgery, 114 2
J. Gurevitch, J. Barak, E. Hochhauser, Y. Paz, V. Yakirevich (1994)
Aprotinin improves myocardial recovery after ischemia and reperfusion. Effects of the drug on isolated rat hearts.The Journal of thoracic and cardiovascular surgery, 108 1
J. Petry, K. Wortham (1984)
The Anatomy of the Epigastric Flap in the Experimental RatPlastic and Reconstructive Surgery, 74
Sultan Sultan, Sunamori Sunamori, Susuki Susuki (1992)
Membrane stabilization, calcium antagonism, and protease inhibition on myocardial viability: A biochemical, iltrastructural, functional studyJ Heart Lung Transplant, 11
M. Kunitz, J. Northrop (1936)
ISOLATION FROM BEEF PANCREAS OF CRYSTALLINE TRYPSINOGEN, TRYPSIN, A TRYPSIN INHIBITOR, AND AN INHIBITOR-TRYPSIN COMPOUNDThe Journal of General Physiology, 19
M. Sunamori, I. Sultan, Akio Suzuki (1991)
Effect of aprotinin to improve myocardial viability in myocardial preservation followed by reperfusion.The Annals of thoracic surgery, 52 4
C. Pang, C. Forrest, R. Mounsey (1993)
Pharmacologic intervention in ischemia‐induced reperfusion injury in the skeletal muscleMicrosurgery, 14
L. Edstrom, Michael Balkovich, G. Slotman (1988)
Effect of ischemic skin flap elevation on tissue and plasma thromboxane A2 and prostacyclin production: modification by thromboxane synthetase inhibition.Annals of Plastic Surgery, 20
E. Zyznar (1981)
A rationale for the application of trasylol as a protease inhibitor in radioimmunoassay.Life sciences, 28 17
Shaheen Shaheen, Punch Punch, Rees Rees (1990)
Early role for neutrophils in skin flap failureSurg Forum, 41
M. Choi, H. Rabb, M. Arnaout, H. Ehrlich (1995)
Preventing the infiltration of leukocytes by monoclonal antibody blocks the development of progressive ischemia in rat burns.Plastic and reconstructive surgery, 96 5
M. Robson, J. Kucan, K. Paik, E. Eriksson (1978)
Prevention of dermal ischemia after thermal injury.Archives of surgery, 113 5
Fritz Fritz, Rüsse Rüsse, Liebich Liebich (1989)
Immunofluorescent studies indicate that the basic trypsin‐kallikrein‐inhibitor of bovine organs (Trasylol) originates from mast cells: Hoppe‐Seyler's ZPhysiol Chem, 360
Multiple drugs have been used in experimental skin flap models to reduce the effects of reperfusion ischemia. The effects of antiproteases, however, have not been studied. A skin flap ischemia reperfusion model was developed in the rat to study the effects that aprotinin, a broad‐spectrum antiserine protease, would have on skin flap viability. Thirty‐two male rats underwent elevation of a ventral pedicled skin flap based on the superficial inferior epigastric artery. The flaps were subjected to 10 hr of warm ischemia by clamping the neurovascular pedicle followed by reperfusion. Aprotinin or saline (control) was administered systemically via the contralateral femoral vein either before or after the ischemic insult. Full‐thickness skin biopsies were obtained at 1, 8, and 24 hr into reperfusion. Biopsies were evaluated for neutrophil concentration (using a myeloperoxidase (MPO) assay) and thromboxane B2 (TxB2) content. Flap survival was calculated at 1 week using standardized photography and computer‐assisted digital imaging. Aprotinin given before an ischemic insult significantly improved flap survival compared to saline controls (52.3% alive vs. 29.6%, P = 0.0132, unpaired t‐test). Aprotinin given after ischemia did not significantly influence flap survival (28.8% vs. 34.4% in saline controls, P = 0.708). MPO levels in the aprotinin preischemia treatment group were significantly less at 1 and 8 hr into reperfusion, indicating decreased neutrophil numbers. No statistical difference in TxB2 levels was noted in either group at any time after reperfusion. Aprotinin significantly improves skin flap survival when given prior to but not after an ischemic insult. Aprotinin appears to lower the concentration of neutrophils in skin flaps pretreated with the drug. Reperfused skin flap levels of thromboxane B2 are unaffected by the pre‐ or postischemic administration of aprotinin. © 1998 Wiley‐Liss, Inc. MICROSURGERY 18:354–361, 1998
Microsurgery – Wiley
Published: Jan 1, 1998
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