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Mammalian Facilitative Glucose Transporter Family: Structure and Molecular Regulation

Mammalian Facilitative Glucose Transporter Family: Structure and Molecular Regulation Jeffrey E. Pessin Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242 Graeme I. Bell Howard Hughes Medical Institute and Departments of Biochemistry, Molecular Biolo­ gy, and Medicine, University of Chicago, Chicago, Illinois 60637 KEY WORDS: insulin, diabetes, adipose, muscle, liver FACILITATIVE GLUCOSE TRANSPORTERS-MOLECULAR STRUCTURE Except for the active uptake of glucose from the lumen of the small intestine and proximal tubule of the kidney, the" transport of glucose across cell membranes' occurs by facilitated diffusion. Currently, cDNAs encoding five structurally-related proteins with the properties of faCilitative glucose transporters have been isolated and characterized (Table I). The five isoforms have been designated GLUT lIerythrocyte, GLUT2/liver, GLUT3/brain, GLUT4/muscle-fat,andGLUT5/smali intestine (25,52). In addition to these five functional facilitative glucose transporters, an expressed facilitative glu­ cose transporter pseudogene-like sequence (GLUT6) has been identified in human tissues (39). This sequence is part of a ubiquitously expressed mRNA, but does not encode a functional protein. The purification and characteriZation of the human erythrocyte glucose transporter provided the basiS" for th"e isolation of human and rat GLUT1 0006-4278/92/03 154>911$02.00 Table 1 PESSIN & BELL Mammalian glucose transporters: major sites of expression and physiological functions Major sites of expression Function Designation A. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Review of Physiology Annual Reviews

Mammalian Facilitative Glucose Transporter Family: Structure and Molecular Regulation

Pessin, J E; Bell, G I
Annual Review of Physiology , Volume 54 (1) – Mar 1, 1992
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References (32)

Publisher
Annual Reviews
Copyright
Copyright 1992 Annual Reviews. All rights reserved
Subject
Review Articles
ISSN
0066-4278
eISSN
1545-1585
DOI
10.1146/annurev.ph.54.030192.004403
pmid
1562197
Publisher site
See Article on Publisher Site

Abstract

Jeffrey E. Pessin Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242 Graeme I. Bell Howard Hughes Medical Institute and Departments of Biochemistry, Molecular Biolo­ gy, and Medicine, University of Chicago, Chicago, Illinois 60637 KEY WORDS: insulin, diabetes, adipose, muscle, liver FACILITATIVE GLUCOSE TRANSPORTERS-MOLECULAR STRUCTURE Except for the active uptake of glucose from the lumen of the small intestine and proximal tubule of the kidney, the" transport of glucose across cell membranes' occurs by facilitated diffusion. Currently, cDNAs encoding five structurally-related proteins with the properties of faCilitative glucose transporters have been isolated and characterized (Table I). The five isoforms have been designated GLUT lIerythrocyte, GLUT2/liver, GLUT3/brain, GLUT4/muscle-fat,andGLUT5/smali intestine (25,52). In addition to these five functional facilitative glucose transporters, an expressed facilitative glu­ cose transporter pseudogene-like sequence (GLUT6) has been identified in human tissues (39). This sequence is part of a ubiquitously expressed mRNA, but does not encode a functional protein. The purification and characteriZation of the human erythrocyte glucose transporter provided the basiS" for th"e isolation of human and rat GLUT1 0006-4278/92/03 154>911$02.00 Table 1 PESSIN & BELL Mammalian glucose transporters: major sites of expression and physiological functions Major sites of expression Function Designation A.

Journal

Annual Review of Physiology – Annual Reviews

Published: Mar 1, 1992

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