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References (39)
-
J. Davies, J. Watkins (1973)
Microelectrophoretic studies on the depressant action of HA-966 on chemically and synaptically excited neurones in the cat cerebral cortex and cuneate nucleus.Brain research, 59
-
E. Work, S. Birnbaum, M. Winitz, J. Greenstein (1955)
Separation of the Three Isomeric Components of Synthetic α,ε-Diaminopimelic Acid1Journal of the American Chemical Society, 77
-
J. Watkins (1962)
THE SYNTHESIS OF SOME ACIDIC AMINO ACIDS POSSESSING NEUROPHARMACOLOGICAL ACTIVITY.Journal of medicinal and pharmaceutical chemistry, 91
-
D. Curtis, G. Johnston (1974)
Amino acid transmitters in the mammalian central nervous system.Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie, 69 0
-
D. Curtis, J. Watkins (1965)
The pharmacology of amino acids related to gamma-aminobutyric acid.Pharmacological reviews, 17 4
-
W. White, J. Nadler, A. Hamberger, C. Cotman, JOSEPH Cummins (1977)
Glutamate as transmitter of hippocampal perforant pathNature, 270
-
J. Davies, J. Watkins (1977)
Effect of magnesium ions on the responses of spinal neurones to excitatory amino acids and acetylcholineBrain Research, 130
-
Dudel Dudel (1977)
Aspartate and other inhibitors of excitatory synaptic transmission in crayfish musclePflügers Arch., 369
-
Evans Evans, Watkins Watkins (1978b)
Dual sites for antagonism of excitatory amino acid actions on central neuronesJ. Physiol., 277
-
T. Biscoe, J. Davies, A. Dray, R. Evans, M. Martin, J. Watkins (1978)
D-α-Aminoadipate, α,ε-diominopimelic acid and HA-966 as antagonists of amino acid-induced and synaptic excitation of mammalian spinal neurones in vivoBrain Research, 148
-
Biscoe Biscoe, Davies Davies, Dray Dray, Evans Evans, Francis Francis, Martin Martin, Watkins Watkins (1977a)
Depression of synaptic excitation and of amino acid‐induced excitatory responses by d‐α‐aminoadipate, α‐diaminopimelic acid and HA‐966Eur. J. Pharmac., 45
-
R. Evans, J. Watkins (1978)
Dual sites for antagonism of excitatory amino acid actions on central neurones [proceedings].The Journal of physiology, 277
-
H. Shinozaki, I. Shibuya (1974)
A new potent excitant, quisqualic acid: effects on crayfish neuromuscular junction.Neuropharmacology, 13 7
-
R. Evans, J. Watkins (1975)
VENTRAL ROOT RESPONSES OF THE HEMISECTED AMPHIBIAN SPINAL CORD TO PERFUSED AMINO ACIDS IN THE PRESENCE OF PROCAINEBritish Journal of Pharmacology, 55
-
J. Rudinger, H. Farkašová (1963)
Amino acids and peptides. XL. Synthesis of L-α-aminoadipic acid and L-β-aminoadipic acid from L-glutamic acidCollection of Czechoslovak Chemical Communications, 28
-
T. Biscoe, R. Evans, A. Francis, M. Martin, J. Watkins, J. Davies, A. Dray (1977)
D-α-Aminoadipate as a selective antagonist of amino acid-induced and synaptic excitation of mammalian spinal neuronesNature, 270
-
(1978)
Role of uptake -
L. Eberson, B. Wickberg, E. Stenhagen, L. Sillén, B. Zaar, E. Diczfalusy (1958)
On the Reaction between Substituted Malonic Esters and Methylene Bromide. II.Acta Chemica Scandinavica, 12
-
R. Evans, J. Watkins (1978)
Specific antagonism of excitant amino acids in the isolated spinal cord of the neonatal rat.European journal of pharmacology, 50 2
-
V. Balcar, Graham Johnston (1972)
Glutamate uptake by brain slices and its relation to the depolarization of neurones by acidic amino acids.Journal of neurobiology, 3 4
-
S. Haldeman, R. Huffman, K. Marshall, H. Mclennan (1972)
The antagonism of the glutamate-induced and synaptic excitations of thalamic neurones.Brain research, 39 2
-
K. Toi, K. Mori, Y. Izumi (1960)
Synthesis of a,a'-Diaminodicarboxylic AcidsBulletin of the Chemical Society of Japan
-
R. Wade, S. Birnbaum, M. Winitz, R. Koegel, J. Greenstein (1957)
Preparation and Properties of the Isomeric Forms of α-Amino- and α,[UNK]-Diaminopimelic AcidJournal of the American Chemical Society, 79
-
J. Greenstein, M. Winitz (1961)
Chemistry of the Amino Acids -
McCulloch McCulloch, Johnston Johnston, Game Game, Curtis Curtis (1974)
The differential sensitivity of spinal interneurones and Renshaw cells to kainate and N‐methyl‐d‐aspartateExpl. Brain Res., 21
-
J. Johnson (1978)
The excitant amino acids glutamic and aspartic acid as transmitter candidates in the vertebrate central nervous systemProgress in Neurobiology, 10
-
L. Rhuland, E. Work, R. Denman, D. Hoare (1955)
The Behavior of the Isomers of α,ε-Diaminopimelic Acid on Paper ChromatogramsJournal of the American Chemical Society, 77
-
(1978)
D-x-Aminoadipate, i,Ediaminopimelic acid and HA-966 -
S. Wu, J. Dowling (1978)
L-aspartate: evidence for a role in cone photoreceptor synaptic transmission in the carp retina.Proceedings of the National Academy of Sciences of the United States of America, 75 10
-
R. Davidoff, R. Adair (1975)
HIGH AFFINITY AMINO ACID TRANSPORT BY FROG SPINAL CORD SLICESJournal of Neurochemistry, 24
-
S. Hase, R. Kiyoi, S. Sakakibara (1968)
Synthesis of DL-α-Aminosuberic Acid and Its Optical ResolutionBulletin of the Chemical Society of Japan, 41
-
J. Davies, R. Evans, A. Francis, J. Watkins (1979)
Excitatory amino acid receptors and synaptic excitation in the mammalian central nervous system.Journal de physiologie, 75 6
-
Graham Johnston, David Curtis, J. Davies, R. Mcculloch (1974)
Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acidNature, 248
-
Evans Evans, Francis Francis, Watkins Watkins (1977)
Selective antagonism by Mg 2+ of amino acid‐induced depolarization of spinal neuronesExperientia, 33
-
G. Johnston, Sue Kennedy, B. Twitchin (1979)
ACTION OF THE NEUROTOXIN KAINIC ACID ON HIGH AFFINITY UPTAKE OF l‐GLUTAMIC ACID IN RAT BRAIN SLICESJournal of Neurochemistry, 32
-
T. Biscoe, R. Evans, P. Headley, M. Martin, J. Watkins (1976)
STRUCTURE‐ACTIVITY RELATIONS OF EXCITATORY AMINO ACIDS ON FROG AND RAT SPINAL NEURONESBritish Journal of Pharmacology, 58
-
N. Buu, E. Puil, N. Gelder (1976)
Receptors for amino acids in excitable tissues.General pharmacology, 7 1
-
R. Evans, A. Francis, J. Watkins (1978)
Mg2+-like selective antagonism of excitatory amino acid-induced responses by α,ε-diaminopimelic acid, D-α-maminoadipate and HA-966 in isolated spinal cord of frog and immature ratBrain Research, 148
-
T. Biscoe, J. Davies, A. Dray, R. Evans, A. Francis, M. Martin, J. Watkins (1977)
Depression of synaptic excitation and of amino acid induced excitatory responses of spinal neurones by D-alpha-aminoadipate, alpha,epsilon-diaminopimelic acid and HA-966.European journal of pharmacology, 45 3
- Publisher
- Wiley
- Copyright
- 1979 British Pharmacological Society
- ISSN
- 0007-1188
- eISSN
- 1476-5381
- DOI
- 10.1111/j.1476-5381.1979.tb08706.x
- Publisher site
- See Article on Publisher Site
Abstract
1 A range of compounds has been tested for excitatory amino acid agonist or antagonist activity and for effects on synaptic activity on isolated hemisected spinal cords of frogs. 2 l‐Monoamino dicarboxylic acids of chain length up to 8 carbon atoms (l‐α‐aminosuberate) were all agonists. 3 Within a series of d‐monoamino dicarboxylic acids, and with diamino dicarboxylic acids (mainly unresolved mixtures of diasteroisomers), there was a progression from agonist activity, for compounds of chain length equal to or shorter than glutamate, to antagonist activity, for compounds of longer chain length. d‐α‐Aminosuberate (DαAS) was the most potent antagonist. 4 The antagonist actions of these substances showed a Mg2+ ‐like selectivity with respect to depolarizations produced by different excitants. N‐methyl‐d‐aspartate (NMDA) was the most susceptible agonist and quisqualate and kainate the least susceptible. Responses to other excitatory amino acids, including l‐glutamate and l‐aspartate, showed intermediate sensitivity to the antagonists. 5 A parallelism was observed between the relative potencies of mono‐ and diamino dicarboxylic acids as NMDA antagonists and their relative potencies as depressants of synaptic responses. 6 The results support the concept of different types of excitatory amino acid receptors, with NMDA and its antagonists acting predominantly on one type. These NMDA receptors are probably transmitter receptors activated by an excitatory amino acid transmitter.
Journal
British Journal of Pharmacology – Wiley
Published: Dec 1, 1979