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D. Overstreet, A. Rezvani, D. Janowsky (1990)
Increased hypothermic responses to ethanol in rats selectively bred for cholinergic supersensitivity.Alcohol and alcoholism, 25 1
R. Peoples, F. Weight (1992)
Ethanol inhibition of N-methyl-d-aspartate-activated ion current in rat hippocampal neurons is not competitive with glycineBrain Research, 571
PE Simson, HE Criswell, GR Breese (1991)
Ethanol potentiates GABA‐mediated inhibition in the inferior colliculus: Evidence for local ethanol/GABA interactionsJ Pharmacol Exp Ther, 259
DH Overstreet, AH Rezvani, DS Janowsky (1990)
Increased hypothermic responses to ethanol in rats selectively bred for cholinergic supersensitivityAlcohol Clin Exp Res, 25
MB Waller, JM Murphy, WJ McBride, L Lumeng, T‐K Li (1986)
Effect of low dose ethanol on spontaneous motor activity in alcohol‐preferring and ‐nonpreferring lines of ratsAlcohol Clin Exp Res, 24
J. Dildy, S. Leslie (1989)
Ethanol inhibits NMDA-induced increases in free intracellular Ca2+ in dissociated brain cellsBrain Research, 499
M Carlson, A Carlson (1989)
Dramatic synergism between MK‐801 and clonidine with respect to locomotor stimulatory effect in monoamine‐depleted miceJ Pharmacol Exp Ther, 77
H. Criswell, G. Breese (1989)
A conflict procedure not requiring deprivation: evidence that chronic ethanol treatment induces tolerance to the anticonflict action of ethanol and chlordiazepoxide.Alcoholism, clinical and experimental research, 13 5
J. Dildy-Mayfield, S. Leslie (1991)
Mechanism of Inhibition of N‐Methyl‐d‐Aspartate‐Stimulated Increases in Free Intracellular Ca2+ Concentration by EthanolJournal of Neurochemistry, 56
M. Waller, James Murphy, W. Mcbride, L. Lumeng, Ting-kai Li (1986)
Effect of low dose ethanol on spontaneous motor activity in alcohol-preferring and -nonpreferring lines of ratsPharmacology Biochemistry and Behavior, 24
K. Spuhler, B. Hoffer, N. Weiner, M. Palmer (1982)
Evidence for genetic correlation of hypnotic effects and cerebellar Purkinje neuron depression in response to ethanol in micePharmacology Biochemistry and Behavior, 17
Ben Givens, G. Breese (1990)
Site-specific enhancement of gamma-aminobutyric acid-mediated inhibition of neural activity by ethanol in the rat medial septal area.The Journal of pharmacology and experimental therapeutics, 254 2
AS Hollister, GR Breese, BR Cooper (1974)
Comparison of tyrosine hydroxyls and dopamine‐β‐hydroxyls inhibition with the effects of various 6‐hydroxydopamine treatments on d‐amphetamine induced by motor activityPsychopharmacology, 36
A. Rezvani, D. Overstreet, D. Janowsky (1990)
Genetic serotonin deficiency and alcohol preference in the fawn hooded rats.Alcohol and alcoholism, 25 5
B. Sanders (1976)
Sensitivity to low doses of ethanol and pentobarbital in mice selected for sensitivity to hypnotic doses of ethanol.Journal of comparative and physiological psychology, 90 4
D. Overstreet, A. Rezvani, D. Janowsky (1992)
Genetic animal models of depression and ethanol preference provide support for cholinergic and serotonergic involvement in depression and alcoholismBiological Psychiatry, 31
B. Clineschmidt, G. Martin, P. Bunting (1982)
Anticonvulsant activity of (+)‐5‐methyl‐10, 11‐dihydro‐5H‐dibenzo[a, d]cyclohepten‐5, 10‐imine (MK‐801), a substance with potent anticonvulsant, central sympathomimetic, and apparent anxiolytic propertiesDrug Development Research, 2
B. Dudek, M. Abbott (1984)
The relationship between ethanol-induced locomotor activation and narcosis in long-sleep and short-sleep mice.Alcoholism, clinical and experimental research, 8 3
SD Iversen, L Singh, RJ Oles, C Preston, MD Tricklebank (1988)
Sigma and Phencyclidine‐Like Compounds as Molecular Probes in BiologyJ Neural Transm
AH Rezvani, DH Overstreet, DS Janowsky (1991)
Drug‐induced reductions in ethanol intake in alcohol‐preferring and fawn‐hooded ratsAlcohol Alcohol, 1
D. Lovinger, G. White, F. Weight (1989)
Ethanol inhibits NMDA-activated ion current in hippocampal neurons.Science, 243 4899
H. Criswell, D. Knapp, D. Overstreet, G. Breese (1994)
Effects of ethanol, chlordiazepoxide, and MK-801 on performance in the elevated-plus maze and on locomotor activity.Alcoholism, clinical and experimental research, 18 3
R. Corbett, R. Dunn (1993)
Effects of 5,7 dichlorokynurenic acid on conflict, social interaction and plus maze behaviorsNeuropharmacology, 32
J. Woodward, R. Gonzales (1990)
Ethanol Inhibition of N‐Methyl‐D‐Aspartate‐Stimulated Endogenous Dopamine Release from Rat Striatal Slices: Reversal by GlycineJournal of Neurochemistry, 54
H. Criswell, K. Johnson, R. Mueller, G. Breese (1993)
Evidence for involvement of brain dopamine and other mechanisms in the behavioral action of the N-methyl-D-aspartic acid antagonist MK-801 in control and 6-hydroxydopamine-lesioned rats.The Journal of pharmacology and experimental therapeutics, 265 2
P. Simson, H. Criswell, G. Breese (1993)
Inhibition of NMDA-evoked electrophysiological activity by ethanol in selected brain regions: evidence for ethanol-sensitive and ethanol-insensitive NMDA-evoked responsesBrain Research, 607
C. Hodge, H. Samson, M. Haraguchi (1992)
Microinjections of dopamine agonists in the nucleus accumbens increase ethanol-reinforced respondingPharmacology Biochemistry and Behavior, 43
D. Overstreet (1993)
The flinders sensitive line rats: A genetic animal model of depressionNeuroscience & Biobehavioral Reviews, 17
K. Breen, C. Regan (1988)
Differentiation‐Dependent Sialylation of Individual Neural Cell Adhesion Molecule Polypeptides During Postnatal DevelopmentJournal of Neurochemistry, 50
JC Crabbe, NA Johnson, DK Gray, A Kosobud, ER Young (1982)
Biphasic effects of ethanol of open‐field activity: Sensitivity and tolerance in C57B1/6N and DBA/2N miceJ Neurochem, 96
HC Becker, RL Hale (1989)
Ethanol‐induced locomotor stimulation in C57BL/6 mice following RO15–4513 administrationBrain Res, 99
E. Wong, J. Kemp, T. Priestley, A. Knight, G. Woodruff, L. Iversen (1986)
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.Proceedings of the National Academy of Sciences of the United States of America, 83 18
AH Rezvani, DH Overstreet, DS Janowsky (1990)
Genetic serotonin deficiency and alcohol preference in the Fawn‐Hooded ratsBiol Psychiatry, 25
K Kiianma, PL Hoffman, B Tabakoff (1983)
Antagonism of the behavioral effects of ethanol by naltrexone in BALB/c, C57BL/6, and DBA/2 micePsychopharmacology, 79
S. Ahlénius, A. Carlsson, J. Engel, T. Svensson, P. dersten (1973)
Antagonism by alpha methyltyrosine of the ethanol‐induced stimulation and euphoria in manClinical Pharmacology & Therapeutics, 14
N Adams, ZK Shihabi, DA Blizard (1991)
Ethanol preference in the Harrington derivation of the Maudsley reactive and nonreactive strainsAlcohol Alcohol, 15
GD Frye, GR Breese (1981)
An evaluation of the locomotor stimulating action of ethanol in rats and micePsychopharmacology, 75
BV Clineschmidt, GE Martin, PR Bunting, NL Papp (1982)
Central sympathomimetic activity of (+)‐5‐Methyl‐10,11‐dihydro‐5H‐dibenzo [a,d]cyclohepten‐5,10‐imine (MK‐801), a substance with potent anticon‐vulsant, central sympathomimetic, and apparent anxiolytic propertiesDrug Dev Res, 2
D. Overstreet, A. Kampov-Polevoy, A. Rezvani, L. Murrelle, J. Halikas, D. Janowsky (1993)
Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains.Alcoholism, clinical and experimental research, 17 2
L Lumeng, TD Hawkins, T‐K Li (1977)
Alcohol and Aldehyde Metabolizing SystemsAlcohol Alcohol, vol 3
L. Lumeng, T. Hawkins, Ting-kai Li (1977)
NEW STRAINS OF RATS WITH ALCOHOL PREFERENCE AND NONPREFERENCE
G. White, D. Lovinger, F. Weight (1990)
Ethanol inhibits NMDA-activated current but does not alter GABA-activated current in an isolated adult mammalian neuronBrain Research, 507
A. Christmas, D. Maxwell (1970)
A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats.Neuropharmacology, 9 1
HE Criswell, KB Johnson, RA Mueller, GR Breese (1993)
Evidence for involvement of brain dopamine in the behavioral action of the NMDA antagonist MK‐801 in control and 6‐hydroxydopamine lesioned rats: Evidence for regionally selective effects in brainPsychopharmacology, 265
D. Overstreet, S. Dilsaver, A. Rezvani, D. Janowsky (1990)
Selective antagonistic effects of exposure to bright light on the hypothermic action of ethanol.Alcohol and alcoholism, 25 6
R Smoothy, M Berry (1984)
Alcohol increases both locomotion and immobility in mice: An ethological analysis of spontaneous motor activityPharmacol Biochem Behav, 83
JE Dildy‐Mayfield, SW Leslie (1991)
Mechanism of inhibition of N‐methyl‐D‐aspartate stimulated increases in free intracellular Ca2+ concentration by ethanolBrain Res, 56
G White, DM Lovinger, FF Weight (1990)
Ethanol inhibits MDA‐activated current but does not alter GABA‐activated current in an isolated adult mammalian neuronProc Natl Acad Sci USA, 507
J. Crabbe, N. Johnson, D. Gray, A. Kosobud, E. Young (1982)
Biphasic effects of ethanol on open-field activity: sensitivity and tolerance in C57BL/6N and DBA/2N mice.Journal of comparative and physiological psychology, 96 3
HE Criswell, PE Simson, GE Duncan, TJ McCown, JS Herbert, AL Morrow, GR Breese (1993)
Molecular basis for regionally specific action of ethanol on GABAA receptor: Generalization to other ligand‐gated ion channelsJ Pharmacol Exp Ther
DH Overstreet, AB Kampov‐Polevoy, AH Resvani, L Murrelle, JA Halikas, DS Janowsky (1993)
Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strainsJ Comp Physiol Psychol, 17
N. Adams, Z. Shihabi, D. Blizard (1991)
Ethanol preference in the Harrington derivation of the Maudsley Reactive and Non-Reactive strains.Alcoholism, clinical and experimental research, 15 2
C. Rabe, B. Tabakoff (1990)
Glycine site-directed agonists reverse the actions of ethanol at the N-methyl-D-aspartate receptor.Molecular pharmacology, 38 6
P. Simson, H. Criswell, Kevin Johnson, R. Hicks, G. Breese (1991)
Ethanol inhibits NMDA-evoked electrophysiological activity in vivo.The Journal of pharmacology and experimental therapeutics, 257 1
P. Hoffman, C. Rabe, F. Moses, B. Tabakoff (1989)
N‐Methyl‐D‐Aspartate Receptors and Ethanol: Inhibition of Calcium Flux and Cyclic GMP ProductionJournal of Neurochemistry, 52
P. Simson, H. Criswell, G. Breese (1991)
Ethanol potentiates gamma-aminobutyric acid-mediated inhibition in the inferior colliculus: evidence for local ethanol/gamma-aminobutyric acid interactions.The Journal of pharmacology and experimental therapeutics, 259 3
Several lines of research have suggested a link between the reward value of a drug and its ability to stimulate locomotion. One goal of the present study was to determine whether ethanol preferentially stimulates locomotor activity in lines of rat that show a preference for ethanol. A secondary goal was to determine the extent to which the benzodiazepine‐like and NMDA antagonistic action of ethanol accounted for its effect on locomotor activity. To meet these goals, the effects of varying doses of ethanol (0.125‐1.0 g/kg), MK‐801 (0.1‐0.3 mg/kg), and chlordiazepoxide (0.3‐3 mg/kg) on locomotor activity were studied in several lines of rats that had been habituated to the testing procedure. The effect of low doses of ethanol on motor activity in the Alcohol‐Preferring (P) and Fawn‐Hooded rats, which show a strong ethanol preference, were similar to those of the alcohol‐nonpreferring (NP), Flinders Sensitive Line, and Flinders Resistant Line rats. Only the Flinder Resistant Line rats showed a small, but significant increase in locomotor activity after the administration of ethanol. The highest dose of ethanol (1.0 g/kg) produced locomotor depression in all lines except the P and NP lines, which were not tested at this dose. These findings do not support a link between locomotor stimulation by ethanol and ethanol preference. In contrast, all lines exhibited locomotor stimulation after moderate (0.1‐0.3 mg/kg) doses of MK‐801, but did not exhibit increases in activity following any dose of chlordiazepoxide. These data indicate that the profiles of activity after MK‐801 and chlordiazepoxide were distinct from that of ethanol in the various rat lines. Therefore, the effects of ethanol on locomotor activity cannot be accounted for by reference solely to its antagonist‐like action at NMDA receptors and/or its agonist‐like action at GABA/benzodiazepine receptors.
Alcoholism: Clinical & Experimental Research – Wiley
Published: Aug 1, 1994
Keywords: ; ; ; ;
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