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K. Mase, Y. Takahashi, K. Ogata (1962)
THE INCORPORATION OF [14C]GLYCINE INTO THE PROTEIN OF GUINEA PIG BRAIN CORTEX SLICESJournal of Neurochemistry, 9
B. Hanking, S. Roberts (1965)
Stimulation of protein synthesis in vitro by elevated levels of amino acids.Biochimica et biophysica acta, 104 2
(1968)
Nature Lond. 221, 1053. PULL
C. Richards, R. Sercombe (1968)
Electrical activity observed in guinea‐pig olfactory cortex maintained in vitroThe Journal of Physiology, 197
Mieczyslaw Wender, Zbigniew Waligóra (1962)
THE CONTENT OF AMINO ACIDS IN THE PROTEINS OF THE DEVELOPING NERVOUS SYSTEM OF THE GUINEA PIG‐IIJournal of Neurochemistry, 9
H. Mcilwain, J. Harvey, G. Rodríguez (1969)
TETRODOTOXIN ON THE SODIUM AND OTHER IONS OF CEREBRAL TISSUES, EXCITED ELECTRICALLY AND WITH GLUTAMATEJournal of Neurochemistry, 16
F. Orrego (1967)
SYNTHESIS OF RNA IN NORMAL AND ELECTRICALLY STIMULATED BRAIN CORTEX SLICES IN VITROJournal of Neurochemistry, 14
(1961)
Biochim . biophys
J. Porteous, B. Clark (1965)
THE ISOLATION AND CHARACTERIZATION OF SUBCELLULAR COMPONENTS OF THE EPITHELIAL CELLS OF RABBIT SMALL INTESTINE.The Biochemical journal, 96
J. Keesey, H. Wallgren (1965)
MOVEMENTS OF RADIOACTIVE SODIUM IN CEREBRAL-CORTEX SLICES IN RESPONSE TO ELECTRICAL STIMULATION.The Biochemical journal, 95
G. Levi, J. Kandera, A. Lajtha (1967)
Control of cerebral metabolite levels. I. Amino acid uptake and levels in various species.Archives of biochemistry and biophysics, 119 1
I. Morgan, L. Austin (1969)
Ion effects and protein synthesis in synaptosomal fraction.Journal of neurobiology, 1 2
F. Orrego, F. Lipmann (1967)
Protein synthesis in brain slices. Effects of electrical stimulation and acidic amino acids.The Journal of biological chemistry, 242 4
S. Sharpless (1964)
REORGANIZATION OF FUNCTION IN THE NERVOUS SYSTEM--USE AND DISUSE.Annual review of physiology, 26
K. Stenzel, R. Aronson, A. Rubin (1966)
In vitro synthesis of brain protein. II. Properties of the complete system.Biochemistry, 5 3
Claire Zomzely, S. Roberts, D. Rapaport (1964)
REGULATION OF CEREBRAL METABOLISM OF AMINO ACIDS—IIIJournal of Neurochemistry, 11
G. Miller (1959)
Protein determination for large numbers of samples.Analytical Chemistry, 31
C. Prives, J. Quastel (1969)
Effects of Cerebral Stimulation on the Biosynthesis in vitro of Nucleotides and RNA in BrainNature, 221
N. Marks, A. Lajtha (1963)
PROTEIN BREAKDOWN IN THE BRAIN. SUBCELLULAR DISTRIBUTION AND PROPERTIES OF NEUTRAL AND ACID PROTEINASES.The Biochemical journal, 89
S. Varon, H. Mcilwain (1961)
FLUID CONTENT AND COMPARTMENTS IN ISOLATED CEREBRAL TISSUESJournal of Neurochemistry, 8
D. Kipnis, E. Reiss, E. Helmreich (1961)
Functional heterogeneity of the intracellular amino acid pool in mammalian cells.Biochimica et biophysica acta, 51
S. Appel, L. Autilio, B. Festoff, A. Escueta (1969)
Biochemical studies of synapses in vitro. 3. Ionic activation of protein synthesis.The Journal of biological chemistry, 244 12
D. Richter (1966)
Biochemical Aspects of Memory
H. Tallan, S. Moore, W. Stein (1954)
Studies on the free amino acids and related compounds in the tissues of the cat.The Journal of biological chemistry, 211 2
R. Pennington (1961)
Biochemistry of dystrophic muscle. Mitochondrial succinate-tetrazolium reductase and adenosine triphosphatase.The Biochemical journal, 80
A. Lajtha (1968)
Transport as control mechanism of cerebral metabolite levels.Progress in brain research, 29
R. Block (1945)
The Amino Acid Composition of Food ProteinsAdvances in Protein Chemistry, 2
C. Jones, P. Banks (1970)
The effect of electrical stimulation on the incorporation of L-[U-14C] valine into the protein of chopped tissue from guinea-pig cerebral cortex.The Biochemical journal, 118 5
S. Lin, W. Mckeehan, W. Culp, B. Hardesty (1969)
Partial characterization of the enzymatic properties of the aminoacyl transfer ribonucleic acid binding enzyme.The Journal of biological chemistry, 244 16
O. Jones (1969)
Multiple light-induced reactions of cytochromes b and c in Rhodopseudomonas spheroides.The Biochemical journal, 114 4
W. Mckeehan, P. Sepulveda, S. Lin, B. Hardesty (1969)
Two distinct transfer enzymes from rabbit reticulocytes with ribosome dependent guanosine triphosphate phosphohydrolase activity.Biochemical and biophysical research communications, 34 5
M. Lubin, H. Ennis (1964)
ON THE ROLE OF INTRACELLULAR POTASSIUM IN PROTEIN SYNTHESIS.Biochimica et biophysica acta, 80
H. Mcilwain (1970)
Metabolic Adaptation in the BrainNature, 226
P. Abadom, P. Scholefield (1962)
Amino acid transport in brain cortex slices. II. Competition between amino acids.Canadian journal of biochemistry and physiology, 40
(1968)
Fedn
L. Austin, I. Morgan (1967)
INCORPORATION OF 14C‐LABELLED LEUCINE INTO SYNAPTOSOMES FROM RAT CEREBRAL CORTEX IN VITROJournal of Neurochemistry, 14
J. Folbergrová (1966)
INCORPORATION OF LABELLED AMINO ACIDS INTO THE PROTEINS OF BRAIN CORTEX SLICES IN VITRO IN THE PRESENCE OF OTHER NON‐RADIOACTIVE AMINO ACIDS *Journal of Neurochemistry, 13
Ralph Arlinghaus, Joseph Shaeffer, R. Schweet (1964)
MECHANISM OF PEPTIDE BOND FORMATION IN POLYPEPTIDE SYNTHESIS.Proceedings of the National Academy of Sciences of the United States of America, 51
C. Yamamoto, H. Mcilwain (1966)
ELECTRICAL ACTIVITIES IN THIN SECTIONS FROM THE MAMMALIAN BRAIN MAINTAINED IN CHEMICALLY‐DEFINED MEDIA IN VITROJournal of Neurochemistry, 13
I. Pull, H. McIlwain, R. Ramsay (1970)
Glutamate, calcium ion-chelating agents and the sodium and potassium ion contents of tissues from the brain.The Biochemical journal, 116 2
J. Keesey, H. Wallgren, H. Mcilwain (1965)
THE SODIUM, POTASSIUM AND CHLORIDE OF CEREBRAL TISSUES: MAINTENANCE, CHANGE ON STIMULATION AND SUBSEQUENT RECOVERY.The Biochemical journal, 95
A. Lajtha (1959)
AMINO ACID AND PROTEIN METABOLISM OF THE BRAIN—VJournal of Neurochemistry, 3
E. Kandel, W. Spencer (1968)
Cellular neurophysiological approaches in the study of learning.Physiological reviews, 48 1
E. Glassman (1969)
The biochemistry of learning: an evaluation of the role of RNA and protein.Annual review of biochemistry, 38
L. Rosenberg, M. Berman, S. Segal (1963)
Studies of the kinetics of amino acid transport, incorporation into portein and oxidation in kidney-cortex slices.Biochimica et biophysica acta, 71
(1962)
Prnctical Neurochemistry
H. Bachelard, W. Campbell, H. Mcilwain (1962)
The sodium and other ions of mammalian cerebral tissues, maintained and electrically stimulated in vitro.The Biochemical journal, 84
—The uptake of radioactive amino acid by incubated cerebral cortex slices is found to be a first order process. Incorporation of the radioactive amino acid into tissue protein is from a precursor pool that has first equilibrated with the intracellular endogenous free amino acids. Ways of calculating the amino acid incorporation in molar quantities from the observed incorporation of radioactivity are discussed, and it is concluded that the specific radioactivity of the intracellular acid‐soluble fraction is the best basis for such estimates. The in vitro incorporation of leucine into tissue protein is estimated to be approximately 1±2 mμnol/mg protein/h, and of valine 0±4 mμmol/mg protein/h. Addition of free amino acids to the media had little or no effect on the calculated rates of incorporation. On incubation for 1 h the total free valine in tissue and medium increased by 0±43 μmol/g and leucine increased by 0±55 μmol/g. Estimates of amino acid incorporation based on the specific radioactivity of the media amino acids can give misleading results if this considerable release of amino acids into the medium is not taken into account. Electrical stimulation of neocortical slices with a variety of types of pulses was either without effect or decreased incorporation into portein. The decrease could not be directly correlated with changes in tissue K+ nor with the utilization of ATP. Mild, local stimulation of the lateral olfactory tract of piriform cortex slices was without effect on tissue phosphocreatine, K+ or amino acid incorporation.
Journal of Neurochemistry – Wiley
Published: Jan 1, 1971
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