Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies

Waist circumference and waist-to-hip ratio as predictors of cardiovascular events:... AimsThe objectives of this study were to determine the association of waist circumference (WC) and waist-to-hip ratio (WHR) with the risk of incident cardiovascular disease (CVD) events and to determine whether the strength of association of WC and WHR with CVD risk is different.Methods and resultsThis meta-regression analysis used a search strategy of keywords and MeSH terms to identify prospective cohort studies and randomized clinical trials of CVD risk and abdominal obesity from the Medline, Embase, and Cochrane databases. Fifteen articles (n 258 114 participants, 4355 CVD events) reporting CVD risk by categorical and continuous measures of WC and WHR were included. For a 1 cm increase in WC, the relative risk (RR) of a CVD event increased by 2 (95 CI: 13) overall after adjusting for age, cohort year, or treatment. For a 0.01 U increase in WHR, the RR increased by 5 (95 CI: 47). These results were consistent in men and women. Overall risk estimates comparing the extreme quantiles of each measure suggested that WHR was more strongly associated with CVD than that for WC (WHR: RR 1.95, 95 CI: 1.552.44; WC: RR 1.63, 95 CI: 1.312.04), although this difference was not significant. The strength of association for each measure was similar in men and women.ConclusionWHR and WC are significantly associated with the risk of incident CVD events. These simple measures of abdominal obesity should be incorporated into CVD risk assessments. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Heart Journal Oxford University Press

Waist circumference and waist-to-hip ratio as predictors of cardiovascular events: meta-regression analysis of prospective studies

Loading next page...
 
/lp/oxford-university-press/waist-circumference-and-waist-to-hip-ratio-as-predictors-of-8j0cHXhOCE

References (52)

Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
ISSN
0195-668X
eISSN
1522-9645
DOI
10.1093/eurheartj/ehm026
pmid
17403720
Publisher site
See Article on Publisher Site

Abstract

AimsThe objectives of this study were to determine the association of waist circumference (WC) and waist-to-hip ratio (WHR) with the risk of incident cardiovascular disease (CVD) events and to determine whether the strength of association of WC and WHR with CVD risk is different.Methods and resultsThis meta-regression analysis used a search strategy of keywords and MeSH terms to identify prospective cohort studies and randomized clinical trials of CVD risk and abdominal obesity from the Medline, Embase, and Cochrane databases. Fifteen articles (n 258 114 participants, 4355 CVD events) reporting CVD risk by categorical and continuous measures of WC and WHR were included. For a 1 cm increase in WC, the relative risk (RR) of a CVD event increased by 2 (95 CI: 13) overall after adjusting for age, cohort year, or treatment. For a 0.01 U increase in WHR, the RR increased by 5 (95 CI: 47). These results were consistent in men and women. Overall risk estimates comparing the extreme quantiles of each measure suggested that WHR was more strongly associated with CVD than that for WC (WHR: RR 1.95, 95 CI: 1.552.44; WC: RR 1.63, 95 CI: 1.312.04), although this difference was not significant. The strength of association for each measure was similar in men and women.ConclusionWHR and WC are significantly associated with the risk of incident CVD events. These simple measures of abdominal obesity should be incorporated into CVD risk assessments.

Journal

European Heart JournalOxford University Press

Published: Apr 2, 2007

Keywords: Cardiovascular disease Abdominal obesity Systematic review Meta-regression

There are no references for this article.