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Connick Connick, Stone Stone (1986)
The effect of kainic, quinolinic and βinic acids on the release of endogenous amino acids from rat brainBiochem. Pharmacol, 35
J. Olney, M. Price, Lisa Samson, J. Labruyere (1986)
The role of specific ions in glutamate neurotoxicityNeuroscience Letters, 65
Alessandro Poli, Andrea Contestabile, P. Migani, Luisa Rossi, C. Rondelli, M. Virgili, R. Bissoli, O. Barnabei (1985)
Kainic Acid Differentially Affects the Synaptosomal Release of Endogenous and Exogenous Amino Acidic NeurotransmittersJournal of Neurochemistry, 45
P. Campochiaro, J. Ferkany, J. Coyle (1985)
Excitatory amino acid analogs evoke release of endogenous amino acids and acetyl choline from chick retina in vitroVision Research, 25
A. Foster, G. Fagg (1984)
Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationship to synaptic receptorsBrain Research Reviews, 7
J. Cha, D. O'Brien, J. Dowling (1986)
Effects of d-aspartate on excitatory amino acid-induced release of [3H]GABA from goldfish retinaBrain Research, 376
W. Nicklas, E. Browning (1983)
Glutamate Uptake and Metabolism in C‐6 Glioma Cells: Alterations by Potassium Ion and Dibutyryl cAMPJournal of Neurochemistry, 41
R. Bourke, K. Nelson (1972)
FURTHER STUDIES ON THE K+‐DEPENDENT SWELLING OF PRIMATE CEREBRAL CORTEX IN VIVO: THE ENZYMATIC BASIS OF THE K+‐DEPENDENT TRANSPORT OF CHLORIDEJournal of Neurochemistry, 19
S. Catsicas, P. Clarke (1987)
Spatiotemporal gradients of kainate‐sensitivity in the developing chicken retinaJournal of Comparative Neurology, 262
D. Choi (1985)
Glutamate neurotoxicity in cortical cell culture is calcium dependentNeuroscience Letters, 58
E. Berdichevsky, N. Riveros, S. Sánchez‐Armass, F. Orrego (1983)
Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitroNeuroscience Letters, 36
S. Yazulla, J. Kleinschmidt (1983)
Carrier-mediated release of GABA from retinal horizontal cellsBrain Research, 263
Rothman Rothman, Thurston Thurston, Hauhart Hauhart (1987)
Delayed neurotoxicity of excitatory amino acidsin vitro. Neuroseience, 22
R. Gill, A. Foster, G. Woodruff (1987)
Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil, 7
Falke Falke, Pace Pace, Chan Chan (1984)
Chloride binding to the anion transport binding sites of band 3J. Biol. Chem, 259
T. Maren (1967)
Carbonic anhydrase: chemistry, physiology, and inhibition.Physiological reviews, 47 4
A. López-Colomé, F. Somohano (1986)
Effect of selective kainate lesions on the release of glutamate and aspartate from chick retinaJournal of Neuroscience Research, 15
E. Mcgeer, J. Olney, P. Mcgeer (1978)
Kainic acid as a tool in neurobiology
987) Hypoxia-ischemia causes glutamate-like neuropathological changes in infant rat brain
J. Ferkany, J. Coyle (1983)
Kainic acid selectively stimulates the release of endogenous excitatory acidic amino acids.The Journal of pharmacology and experimental therapeutics, 225 2
V. Niggli, E. Sigel, E. Carafoli (1982)
Inhibition of the purified and reconstituted calcium pump of erythrocytes by μM levels of dids and nap‐taurineFEBS Letters, 138
S. Rothman (1985)
The neurotoxicity of excitatory amino acids is produced by passive chloride influx, 5
M. Price, J. Olney, Lisa Samson, J. Labruyere (1985)
Calcium influx accompanies but does not cause excitotoxin-induced neuronal necrosis in retinaBrain Research Bulletin, 14
J. Dykens, A. Stern, E. Trenkner (1987)
Mechanism of Kainate Toxicity to Cerebellar Neurons In Vitro Is Analogous to Reperfusion Tissue InjuryJournal of Neurochemistry, 49
J. McRoberts, S. Erlinger, M. Rindler, M. Saier (1982)
Furosemide-sensitive salt transport in the Madin-Darby canine kidney cell line. Evidence for the cotransport of Na+, K+, and Cl-.The Journal of biological chemistry, 257 5
R. Schwarcz, J. Coyle (1977)
Kainic acid: neurotoxic effects after intraocular injection.Investigative ophthalmology & visual science, 16 2
M. Neal (1976)
Amino acid transmitter substances in the vertebrate retina.General pharmacology, 7 5
D. Lucas, J. Newhouse (1957)
The toxic effect of sodium L-glutamate on the inner layers of the retina.A.M.A. archives of ophthalmology, 58 2
G. Johnston, Sue Kennedy, B. Twitchin (1979)
ACTION OF THE NEUROTOXIN KAINIC ACID ON HIGH AFFINITY UPTAKE OF l‐GLUTAMIC ACID IN RAT BRAIN SLICESJournal of Neurochemistry, 32
J. Olney (1982)
THE TOXIC EFFECTS OF GLUTAMATE AND RELATED COMPOUNDS IN THE RETINA AND THE BRAINRetina, 2
E. Wolpaw, D. Martin (1984)
Cl− transport in a glioma cell line: Evidence for two transport mechanismsBrain Research, 297
P. Sarthy (1983)
Release of [3H]gamma-aminobutyric acid from glial (Muller) cells of the rat retina: effects of K+, veratridine, and ethylenediamine, 3
J. Connick, T. Stone (1986)
The effect of kainic, quinolinic and beta-kainic acids on the release of endogenous amino acids from rat brain slices.Biochemical pharmacology, 35 20
S. Rothman (1984)
Synaptic release of excitatory amino acid neurotransmitter mediates anoxic neuronal death, 4
Gibson Gibson, Reif‐Lehrer Reif‐Lehrer (1984)
In vitro effects of kainate on embryonic and post‐hatching chick retinaDev Brain Res., 15
Hyndman Hyndman, Adler Adler (1982a)
Analysis of glutamate uptake and monosodium glutamate toxicity in neural retina monolayer culturesDev Brain Res., 2
Hyndman Hyndman, Adler Adler (1982b)
GABA uptake and release in purified neuronal and non‐neuronal cultures from chick embryo retinaDev Brain Res., 3
W. Nicklas, G. Zeevalk, A. Hyndman (1987)
Interactions between neurons and glia in glutamate/glutamine compartmentation.Biochemical Society transactions, 15 2
S. Rothman, J. Thurston, R. Hauhart (1987)
Delayed neurotoxicity of excitatory amino acids In vitroNeuroscience, 22
M. Récasens, J. Pin, J. Bockaert (1987)
Chloride transport blockers inhibit the chloride-dependent glutamate binding to rat brain membranesNeuroscience Letters, 74
Lucas Lucas, Newhouse Newhouse (1957)
The toxic effect of sodium L‐glutamate on the inner layers of the retinaArch. Ophthalmol, 58
B. Gibson, L. Reif‐Lehrer (1984)
In vitro effects of kainate on embryonic and posthatching chick retina.Brain research, 317 1
M. White, C. Miller (1979)
A voltage-gated anion channel from the electric organ of Torpedo californica.The Journal of biological chemistry, 254 20
J. Olney, M. Price, T. Fuller, J. Labruyere, Lisa Samson, Michael Carpenter, Kathryn Mahan (1986)
The anti-excitotoxic effects of certain anesthetics, analgesics and sedative-hypnoticsNeuroscience Letters, 68
M. Kessler, G. Petersen, Hai Vu, M. Baudry, G. Lynch (1987)
l‐Phenylalanyl‐l‐Glutamate‐Stimulated, Chloride‐Dependent Glutamate Binding Represents Glutamate Sequestration Mediated by an Exchange SystemJournal of Neurochemistry, 48
P. Spencer, A. Ludolph, M. Dwivedi, D. Roy, J. Hugon, H. Schaumburg (1986)
LATHYRISM: EVIDENCE FOR ROLE OF THE NEUROEXCITATORY AMINOACID BOAAThe Lancet, 328
A. Plaitakis, S. Berl, Yahr (1982)
Abnormal glutamate metabolism in an adult-onset degenerative neurological disorder.Science, 216 4542
J. Coyle, R. Schwarcz (1976)
Lesion of striatal neurons with kainic acid provides a model for Huntington's choreaNature, 263
B. Krespan, S. Berl, W. Nicklas (1982)
Alteration in Neuronal‐Glial Metabolism of Glutamate by the Neurotoxin Kainic AcidJournal of Neurochemistry, 38
U. Jönsson, M. Lundström, Å. Sellström, B. Ehinger (1986)
Calcium-independent release of γ-aminobutyrate from nerve processes in the developing rabbit retinaNeuroscience, 17
W. Nicklas, B. Krespan, S. Berl (1980)
Effect of kainate on ATP levels and glutamate metabolism in cerebellar slices.European journal of pharmacology, 62 2-3
J. Nadler, B. Perry, C. Cotman (1978)
Intraventricular kainic acid preferentially destroys hippocampal pyramidal cellsNature, 271
R. Simon, J. Swan, T. Griffiths, B. Meldrum (1984)
Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain.Science, 226 4676
W. Maragos, J. Greenamyre, J. Penney, A. Young (1987)
Glutamate dysfunction in Alzheimer's disease: an hypothesisTrends in Neurosciences, 10
H. Kimelberg, S. Biddlecome, S. Narumi, R. Bourke (1978)
ATPase and carbonic anhydrase activities of bulk-isolated neuron, glia and synaptosome fractions from rat brainBrain Research, 141
A. Hyndman, R. Adler (1981)
Analysis of glutamate uptake and monosodium glutamate toxicity in neural retina monolayer cultures.Brain research, 254 2
A. Guidotti (1990)
Neurotoxicity of excitatory amino acids
A. Hyndman, R. Adler (1982)
GABA uptake and release in purified neuronal and nonneuronal cultures from chick embryo retina.Brain research, 255 2
F. Seil, W. Woodward (1980)
Kainic acid neurotoxicity in granuloprival cerebellar culturesBrain Research, 197
Berdichevsky Berdichevsky, Riveros Riveros, Sanchez‐Armass Sanchez‐Armass, Orrego Orrego (1983)
Kainate, N‐methylaspartate and other excitatory amino acids increase calcium flux into rat brain cortex cellsin vitro. Neurosci. Lett., 36
S. Ross, M. Seelig, P. Spencer (1987)
Specific antagonism of excitotoxic action of ‘uncommon’ amino acids assayed in organotypic mouse cortical culturesBrain Research, 425
D. Calne, E. McGeer, A. Eisen, P. Spencer (1986)
ALZHEIMER'S DISEASE, PARKINSON'S DISEASE, AND MOTONEURONE DISEASE: ABIOTROPIC INTERACTION BETWEEN AGEING AND ENVIRONMENT?The Lancet, 328
J. Falke, R. Pace, S. Chan (1984)
Chloride binding to the anion transport binding sites of band 3. A 35Cl NMR study.The Journal of biological chemistry, 259 10
V. Gallo, R. Suergiu, C. Giovannini, G. Levi (1987)
Glutamate Receptor Subtypes in Cultured Cerebellar Neurons: Modulation of Glutamate and γ‐Aminobutyric Acid ReleaseJournal of Neurochemistry, 49
White White, Miller Miller (1979)
A voltage‐gated anion channel from the electric organ ofTorpedo califomica. J. Biol. Chem., 254
D. Choi, M. Maulucci-Gedde, A. Kriegstein (1987)
Glutamate neurotoxicity in cortical cell culture, 7
D. Casper, R. Trelstad, L. Reif‐Lehrer (1982)
Glutamate‐induced cellular injury in isolated chick embryo retina: Müller cell localization of initial effectsJournal of Comparative Neurology, 209
Abstract: Acute excitotoxicity in embryonic chick retina and the ability of C1− channel blockers to prevent toxicity were evaluated by measurement of endogenous amino acid release and histology. Treatment of retina with kainate, quisqualate, or N‐methyl‐D‐aspartate resulted in a large dose‐dependent release of γ‐aminobutyric acid and taurine, moderate release of glutamine and alanine, and no measurable release of glu‐tamate or aspartate. Concentrations inducing maximal γ‐aminobutyric acid release were 50 μM quisqualate, 100 μM kainate, and 100 μM N‐methyl‐D‐aspartate. Treatment with 1 mM glutamate resulted in significant γ‐aminobutyric acid release, as well as an elevation in medium aspartate levels. Typical excitotoxic retinal lesions were produced by the agonists and, at the lower concentrations tested, revealed a regional sensitivity. There was a positive correlation between the amount of γ‐aminobutyric acid release and the extent of tissue swelling, suggesting that release may be secondary to toxic cellular events. Omission of C1− completely blocked cytotoxic effects due to kainate or glutamate. Likewise, addition of the C1−/bicarbonate anion channel blocker 4,4′‐di‐isothiocyanatostilbene‐2,2′‐disulfonate at 600 μM protected retina from cytotoxic damage from all excitotoxic analogs and restored amino acid levels to baseline values. Furosemide. which blocks Na+/K+/2C1− cotransport, was only minimally effective in reducing amino acid release induced by the agonists. Consistent with the latter, histological examination showed the continued presence of the lesion but with general reduction of cellular edema. These results indicate that although influx of C1− is a central component of the acute excitotoxic phenomenon, mechanisms other than passive Cl−flux may be involved.
Journal of Neurochemistry – Wiley
Published: Nov 1, 1989
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