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(1994)
Ciliary neutrophic factor and
G. Georgsson, E. Gísladóttir, S. Árnadóttir (1993)
Quantitative assessment of the astrocytic response in natural scrapie of sheep.Journal of comparative pathology, 108 3
T. Beach, R. Walker, E. Mcgeer (1989)
Patterns of gliosis in alzheimer's disease and aging cerebrumGlia, 2
L. Acarín, JoséM. Vela, B. González, B. Castellano (1994)
Demonstration of poly-N-acetyl lactosamine residues in ameboid and ramified microglial cells in rat brain by tomato lectin binding.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 42
A. Cunha, J. Jefferson, W. Tyor, J. Glass, F. Jannotta, Ljubisˇa Vitkovic´ (1993)
Control of astrocytosis by interleukin-1 and transforming growth factor-β1 in human brainBrain Research, 631
G. Gosztonyi, V. Schmidt, R. Nickel, M. Rothschild, S. Camacho, Günter Siegel, E. Zill, G. Pauli, V. Schneider (1993)
Neuropathologic analysis of postmortal brain samples of HIV-seropositive and -seronegative i.v. drug addicts.Forensic science international, 62 1-2
J. Relton, N. Rothwell (1992)
Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the ratBrain Research Bulletin, 29
M. Eddleston, L. Mucke (1993)
Molecular profile of reactive astrocytes—Implications for their role in neurologic diseaseNeuroscience, 54
T. Bártfai, M. Schultzberg (1993)
Cytokines in neuronal cell typesNeurochemistry International, 22
Dennis Landis (1994)
The early reactions of non-neuronal cells to brain injury.Annual review of neuroscience, 17
F. Houssiau, K. Bukasa, C. Sindic, J. Damme, J. Snick (1988)
Elevated levels of the 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system.Clinical and experimental immunology, 71 2
E. Ling, W. Wong (1993)
The origin and nature of ramified and amoeboid microglia: A historical review and current conceptsGlia, 7
S. Toulmond, X. Vigé, D. Fage, J. Benavides (1992)
Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neuronsNeuroscience Letters, 144
M. Roth (1987)
A quantitative assessment
Karl 'll, T. Leist, A. Meager, Paolo 'll, D. Leppert, R. Zinkernagel, Adriano Ii, J. Snick (1988)
Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. Evaluation in a murine model infection and in patientsThe Journal of Experimental Medicine, 168
B. Schöbitz, E. Kloet, W. Sutanto, F. Holsboer (1993)
Cellular Localization of Interleukin 6 mRNA and Interleukin 6 Receptor mRNA in Rat BrainEuropean Journal of Neuroscience, 5
R. Lawn, A. Efstratiadis, C. O'Connell, T. Maniatis (1980)
The nucleotide sequence of the human beta-globin gene.Cell, 21 3
S. Forss-Petter, P. Danielson, S. Catsicas, E. Battenberg, J. Price, M. Nerenberg, Gregor Sutcliffe (1990)
Transgenic mice expressing β-galactosidase in mature neurons under neuron-specific enolase promoter controlNeuron, 5
A. Vecchi, C. Garlanda, M. Lampugnani, M. Resnati, Cristian Matteucci, A. Stoppacciaro, H. Schnurch, W. Risau, L. Ruco, A. Mantovani (1994)
Monoclonal antibodies specific for endothelial cells of mouse blood vessels. Their application in the identification of adult and embryonic endothelium.European journal of cell biology, 63 2
P. Gallo, K. Frei, C. Rordorf, J. Lazdins, B. Tavolato, A. Fontana (1989)
Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluidJournal of Neuroimmunology, 23
Julie Wood, P. Wood, R. Ryan, N. Graff-Radford, C. Pilapil, Y. Robitaille, R. Quirion (1993)
Cytokine indices in Alzheimer's temporal cortex: no changes in mature IL-1β or IL-1RA but increases in the associated acute phase proteins IL-6, α2-macroglobulin and C-reactive proteinBrain Research, 629
M. Fiorillo, A. Cabibbo, Paola Iacopetti, E. Fattori, G. Ciliberto (1992)
Analysis of human/mouse interleukin‐6 hybrid proteins: both amino and carboxy termini of human interleukin‐6 are required for in vitro receptor bindingEuropean Journal of Immunology, 22
J. Snick, S. Cayphas, A. Vink, C. Uyttenhove, P. Coulie, M. Rubira, R. Simpson (1986)
Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.Proceedings of the National Academy of Sciences of the United States of America, 83 24
Zsuzsa Fabry, C. Raine, Michael Hart (1994)
Nervous tissue as an immune compartment: the dialect of the immune response in the CNS.Immunology today, 15 5
B. Motro, A. Itin, L. Sachs, E. Keshet (1990)
Pattern of interleukin 6 gene expression in vivo suggests a role for this cytokine in angiogenesis.Proceedings of the National Academy of Sciences of the United States of America, 87
R. Lawn, A. Efstratiadis, C. O'Connell, T. Maniatis (1980)
The nucleotide sequence of the human β-globin geneCell, 21
I. Campbell, C. Abraham, E. Masliah, Phillip Kemper, J. Inglis, M. Oldstone, L. Mucke (1993)
Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.Proceedings of the National Academy of Sciences of the United States of America, 90 21
J. Sutcliffe (1988)
mRNA in the mammalian central nervous system.Annual review of neuroscience, 11
P. Chomczyński, N. Sacchi (1987)
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.Analytical biochemistry, 162 1
IL-6 overproduction in brain of transgenic mice 2449
S. Suematsu, Tadashi Matsuda, K. Aozasa, S. Akira, N. Nakano, S. Ohno, J. Miyazaki, K. Yamamura, T. Hirano, T. Kishimoto (1989)
IgG1 plasmacytosis in interleukin 6 transgenic mice.Proceedings of the National Academy of Sciences of the United States of America, 86 19
G. Opdenakker, G. Opdenakker, J. Damme (1994)
Cytokine-regulated proteases in autoimmune diseases.Immunology today, 15 3
M. Matsuda, K. Miyagi, N. Yanagisawa, N. Tsukada, J. Nakayama (1993)
[Effect of intracerebral injections of tumor necrosis factor and interleukin-1].Arerugi = [Allergy], 42 10
M. Morganti-kossmann, T. Kossmann, S. Wahl (1992)
Cytokines and neuropathology.Trends in pharmacological sciences, 13 7
H. Yan, Miguel Banos, P. Herregodts, R. Hooghe, E. Hooghe-Peters (1992)
Expression of interleukin (IL)‐1β, IL‐6 and their respective receptors in the normal rat brain and after injuryEuropean Journal of Immunology, 22
K. Frei, T. Leist, P. Gallo, D. Leppert, R. Zinkernagel, A. Fontana (1988)
Production of B Cell Stimulatory Factor-2 and Interferon Y in the Central Nervous System during Viral Meningitis and Encephalitis Evaluation in a Murine Model Infection and in Patients Brief Definitive Report
D. Lazzaro, M. Price, M. Felice, R. Lauro (1991)
The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain.Development, 113 4
(1983)
Neuron specific enolase as a marker for differentiation in neurons and neuroendocrine cells
S. Suematsu, T. Matsusaka, Tadashi Matsuda, S. Ohno, J. Miyazaki, K. Yamamura, T. Hirano, T. Kishimoto (1992)
Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice.Proceedings of the National Academy of Sciences of the United States of America, 89 1
C. Petito, I. Halaby (1993)
Relationship between ischemia and ischemic neuronal necrosis to astrocyte expression of glial fibrillary acidic proteinInternational Journal of Developmental Neuroscience, 11
Margot Mayer, K. Bhakoo, M. Noble (1994)
Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro.Development, 120 1
N. Rothwell, J. Relton (1993)
Involvement of cytokines in acute neurodegeneration in the CNSNeuroscience & Biobehavioral Reviews, 17
K. Gijbels, J. Damme, P. Proost, W. Put, H. Carton, A. Billiau (1990)
Interleukin 6 production in the central nervous system during experimental autoimmune encephalomyelitisEuropean Journal of Immunology, 20
Vijayabalan Balasingam, Trevor Tejada-Berges, Erin Wright, Radka Bouckova, V. Yong (1994)
Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines, 14
Y. Yamasaki, TakashiA. Suzuki, H. Yamaya, N. Matsuura, H. Onodera, K. Kogure (1992)
Possible involvement of interleukin-1 in ischemic brain edema formationNeuroscience Letters, 142
L. Dente, R. Cortese (1987)
pEMBL: a new family of single-stranded plasmids for sequencing DNA.Methods in enzymology, 155
J. Bauer, S. Strauss, U. Schreiter-Gasser, U. Ganter, P. Schlegel, I. Witt, Benedikt Yolk, M. Berger (1991)
Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease corticesFEBS Letters, 285
E. Fattori, C. Rocca, P. Costa, M. Giorgio, B. Dente, L. Pozzi, G. Ciliberto (1994)
Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice.Blood, 83 9
B. Barres, R. Schmid, M. Sendnter, M. Raff (1993)
Multiple extracellular signals are required for long-term oligodendrocyte survival.Development, 118 1
Growing evidence suggests that aberrant production of inflammatory cytokines within the central nervous system (CNS) contributes to the development of pathological conditions. To test the cause—effect relationship between the overproduction of interleukin‐6 (IL‐6) in the CNS and the onset of neuropathological changes, we have generated transgenic mice in which human IL‐6 expression has been targeted to the neurons by using the rat neuron‐specific enolase promoter. These mice develop reactive astrocytosis and an increase in ramified microglial cells but do not show histological or behavioural signs of neuron damage at the light microscope level. We thus conclude that a constant release of human IL‐6 by neuronal subpopulations in mice is sufficient to activate cells potentially capable of modulating the local immune response, but at the same time is compatible with normal neuron functions.
European Journal of Neuroscience – Wiley
Published: Dec 1, 1995
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