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Clonal Type I Interferon–producing and Dendritic Cell Precursors Are Contained in Both Human Lymphoid and Myeloid Progenitor Populations

Clonal Type I Interferon–producing and Dendritic Cell Precursors Are Contained in Both Human... Because of different cytokine responsiveness, surface receptor, and transcription factor expression, human CD11c − natural type I interferon–producing cells (IPCs) and CD11c + dendritic cells were thought to derive through lymphoid and myeloid hematopoietic developmental pathways, respectively. To directly test this hypothesis, we used an in vitro assay allowing simultaneous IPC, dendritic cell, and B cell development and we tested lymphoid and myeloid committed hematopoietic progenitor cells for their developmental capacity. Lymphoid and common myeloid and granulocyte/macrophage progenitors were capable of developing into both functional IPCs, expressing gene transcripts thought to be associated with lymphoid lineage development, and into dendritic cells. However, clonal progenitors for both populations were about fivefold more frequent within myeloid committed progenitor cells. Thus, in humans as in mice, natural IPC and dendritic cell development robustly segregates with myeloid differentiation. This would fit with natural interferon type I–producing cell and dendritic cell activity in innate immunity, the evolutionary older arm of the cellular immune system. human hematopoietic progenitors plasmacytoid dendritic cells dendritic cells development hematopoietic lineage commitment Footnotes Submitted: 23 April 2004 Accepted: 11 October 2004 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Experimental Medicine Rockefeller University Press

Clonal Type I Interferon–producing and Dendritic Cell Precursors Are Contained in Both Human Lymphoid and Myeloid Progenitor Populations

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Publisher
Rockefeller University Press
Copyright
© 2004 Rockefeller University Press
ISSN
0022-1007
eISSN
1540-9538
DOI
10.1084/jem.20040809
pmid
15557348
Publisher site
See Article on Publisher Site

Abstract

Because of different cytokine responsiveness, surface receptor, and transcription factor expression, human CD11c − natural type I interferon–producing cells (IPCs) and CD11c + dendritic cells were thought to derive through lymphoid and myeloid hematopoietic developmental pathways, respectively. To directly test this hypothesis, we used an in vitro assay allowing simultaneous IPC, dendritic cell, and B cell development and we tested lymphoid and myeloid committed hematopoietic progenitor cells for their developmental capacity. Lymphoid and common myeloid and granulocyte/macrophage progenitors were capable of developing into both functional IPCs, expressing gene transcripts thought to be associated with lymphoid lineage development, and into dendritic cells. However, clonal progenitors for both populations were about fivefold more frequent within myeloid committed progenitor cells. Thus, in humans as in mice, natural IPC and dendritic cell development robustly segregates with myeloid differentiation. This would fit with natural interferon type I–producing cell and dendritic cell activity in innate immunity, the evolutionary older arm of the cellular immune system. human hematopoietic progenitors plasmacytoid dendritic cells dendritic cells development hematopoietic lineage commitment Footnotes Submitted: 23 April 2004 Accepted: 11 October 2004

Journal

The Journal of Experimental Medicine – Rockefeller University Press

Published: Dec 6, 2004

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