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(1987)
Animal models of anxiety : the effect ofcompounds that modify serotonergic function
M. Hamon, J. Cossery, U. Spampinato, H. Gozlan (1986)
Are there selective ligands for 5-HT1A and 5-HT1B receptor binding sites in brain?Trends in Pharmacological Sciences, 7
M. Critchley, S. Handley (2004)
Effects in the X-maze anxiety model of agents acting at 5-HT1 and 5-HT2 receptorsPsychopharmacology, 93
Roger Newton, John Marunycz, Marc Alderdice, Michael Napoliello (1986)
Review of the side-effect profile of buspirone.The American journal of medicine, 80 3B
G. Goodwin, Rosemarie Souza, A. Green (2004)
The effects of a 5-HT1 receptor ligand isapirone (TVX Q 7821) on 5-HT synthesis and the behavioural effects of 5-HT agonists in mice and ratsPsychopharmacology, 89
K. Martin, R. Mason (1987)
Isapirone is a partial agonist at 5-hydroxytryptamine 1A (5-HT1A) receptors in the rat hippocampus: electrophysiological evidence.European journal of pharmacology, 141 3
C. Dourish, P. Hutson, G. Curzon (1986)
Pustative anxiolytics 8-OH-DPAT, buspirone and TVX Q 7821 are agonists at 5-HT1A autoreceptors in the raphé nucleiTrends in Pharmacological Sciences, 7
(1986)
The nonbenzodiazepine axiolytics buspirone and ipsapirone antagonise serotonin - mediated behavioural responses
M. Joseph, G. Kennett (1983)
Stress-induced release of 5-HT in the hippocampus and its dependence on increased tryptophan availability: an in vivo electrochemical studyBrain Research, 270
(1982)
Potential nonbenzodiazepine anxiolytic
J. Traber, T. Glaser (1987)
5-HT1A receptor-related anxiolyticsTrends in Pharmacological Sciences, 8
S. Handley, S. Mithani (1984)
Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of ‘fear’-motivated behaviourNaunyn-Schmiedeberg's Archives of Pharmacology, 327
S. Pellow, A. Johnston, S. File (1987)
Selective agonists and antagonists for 5‐hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus‐maze test in the ratJournal of Pharmacy and Pharmacology, 39
R. Andrade, R. Nicoll (1987)
Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampusNaunyn-Schmiedeberg's Archives of Pharmacology, 336
(1991)
Serotonin in animal models of anxiety : the importance of stimulus and response
G. Curzon, A. Green (1970)
Rapid method for the determination of 5‐hydroxytryptamine and 5‐hydroxyindoleacetic acid in small regions of rat brainBritish Journal of Pharmacology, 39
B. Söderpalm, S. Hjorth, J. Engel (1989)
Effects of 5-HT1A receptor agonists and L-5-HTP in Montgomery's conflict testPharmacology Biochemistry and Behavior, 32
L. Riblet, Duncan Taylor, M. Eison, H. Stanton (1982)
Pharmacology and neurochemistry of buspirone.The Journal of clinical psychiatry, 43 12 Pt 2
K. Kantak, M. Wayner, J. Stein (1978)
Effects of various periods of food deprivation on serotonin turnover in the lateral hypothalamusPharmacology Biochemistry and Behavior, 9
J. Crist, A. Surprenant (1987)
Evidence that 8‐hydroxy‐2‐(n‐dipropylamino)tetralin (8‐OH‐DPAT) is a selective α2‐adrenoceptor antagonist on guinea‐pig submucous neuronesBritish Journal of Pharmacology, 92
5 - HT 1 A ligand effects in the X - maze anxiety test
J. Traber, M. Davies, W. Dompert, T. Glaser, T. Schuurman, P. Seidel (1984)
Brain serotonin receptors as a target for the putative anxiolytic TVX Q 7821Brain Research Bulletin, 12
J. Gray (1985)
The neuropsychology of anxiety.Issues in mental health nursing, 7 1-4
G. Higgins, A. Bradbury, B. Jones, N. Oakley (1988)
Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphé nucleus of the ratNeuropharmacology, 27
M. Briley, P. Chopin, C. Moret (2005)
Effect of serotonergic lesion on “anxious” behaviour measured in the elevated plus-maze test in the ratPsychopharmacology, 101
(1988)
Prevention of 80 HDPAT anxiogenic effect by ipsapirone and 5 - HT ~ antagonist beta - blockers
Paul Moser, M. Tricklebank, D. Middlemiss, Anis Mir, Marcel Hibert, J. Fozard (1990)
Characterization of MDL 73005EF as a 5‐HT1A selective ligand and its effects in animal models of anxiety: comparison with buspirone, 8‐OH‐DPAT and diazepamBritish Journal of Pharmacology, 99
M. Vivo, Saul Maayani (1986)
Characterization of the 5-hydroxytryptamine1a receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes.The Journal of pharmacology and experimental therapeutics, 238 1
J. Engel, S. Hjorth, K. Svensson, A. Carlsson, S. Liljequist (1984)
Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT).European journal of pharmacology, 105 3-4
K. Kantak, M. Wayner, J. Stein (1978)
Effects of various periods of food deprivation on serotonin synthesis in the lateral hypothalamusPharmacology Biochemistry and Behavior, 9
M. Carli, R. Samanin (2004)
Potential anxiolytic properties of 8-hydroxy-2-(Di-N-propylamino)tetralin, a selective serotonin1A receptor agonistPsychopharmacology, 94
Sheila Handley, J. McBlane (1991)
5-HT-the disengaging transmitter?Journal of Psychopharmacology, 5
(1988)
Effects of MDL 73005 EF in animal models predictive of anxiolytic activity
G. Bianchi, S. Caccia, F. Vedova, S. Garattini (1988)
The alpha 2-adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP).European journal of pharmacology, 151 3
L. Pellegrino, A. Cushman (1967)
stereotaxic atlas of the rat brain
(1985)
Pharmacological studies of the role of serotonin in animal models of anxiety
(1986)
Dissociation of efficacy from affinity at the 5 - HT 1 A receptor in rat hippocampal preparation
F. J., William, Deakin, G. Frederico, Graeff (1991)
5-HT and mechanisms of defenceJournal of Psychopharmacology, 5
Paul Moser (2004)
An evaluation of the elevated plus-maze test using the novel anxiolytic buspironePsychopharmacology, 99
(1989)
Dorsal raphe lesions abolish effects of 8 - OHDPAT and ipsapirone in X - maze
S. Peroutka (1985)
Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptorsBiological Psychiatry, 20
J. Bockaert, A. Dumuis, R. Bouhelal, M. Sebben, R. Cory (1987)
Piperazine derivatives including the putative anxiolytic drugs, buspirone and ipsapirone, are agonists at 5-HT1A receptors negatively coupled with adenylate cyclase in hippocampal neuronsNaunyn-Schmiedeberg's Archives of Pharmacology, 335
Jeffery Sprouse, G. Aghajanian (1986)
(-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists.European journal of pharmacology, 128 3
M. Sills, B. Wolfe, A. Frazer (1984)
Determination of selective and nonselective compounds for the 5-HT 1A and 5-HT 1B receptor subtypes in rat frontal cortex.The Journal of pharmacology and experimental therapeutics, 231 3
F. Jenck, C. Broekkamp, A. Delft (1989)
Opposite control mediated by central 5-HT1A and non-5-HT1A (5-HT1B or 5-HT1C) receptors on periaqueductal gray aversion.European journal of pharmacology, 161 2-3
C. Vandermaelen, G. Matheson, G. Matheson, R. Wilderman, Lisa Patterson, Lisa Patterson (1986)
Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administration of buspirone, a non-benzodiazepine anxiolytic drug.European journal of pharmacology, 129 1-2
V. Hillegaart, S. Hjorth (1989)
Median raphe, but not dorsal raphe, application of the 5-HT1A agonist 8-OH-DPAT stimulates rat motor activity.European journal of pharmacology, 160 2
David Bloxam, William Warren (1974)
Error in the determination of tryptophan by the method of Denkla and Dewey. A revised procedure.Analytical biochemistry, 60 2
K. Goa, A. Ward (1986)
Buspirone. A preliminary review of its pharmacological properties and therapeutic efficacy as an anxiolytic.Drugs, 32 2
C. Dourish, S. Ahlénius, P. Hutson (1987)
Brain 5-HT[1A] receptors : behavioural and neurochemical pharmacology
(1987)
Brain 5 HT 1 A receptors and anxiety
V. Hillegaart, S. Hjorth, S. Ahlénius (2005)
Effects of 5-HT and 8-OH-DPAT on forebrain monoamine synthesis after local application into the median and dorsal raphe nuclei of the ratJournal of Neural Transmission / General Section JNT, 81
J. Sprouse, G. Aghajanian (1988)
Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: A comparative study with dorsal raphe neuronsNeuropharmacology, 27
213 106 106 4 4 M. A. E. Critchley K. Njung'e Sheila L. Handley Pharmacology Department Wellcome Research Laboratories Beckenham Kent UK Kenya Medical Research Institute P.O. Box 54840 Nairobi, Kenya South Africa Pharmacology Research, Pharmaceutical Sciences Institute Aston University B4 7ET Birmingham UK Abstract Effects of 5-HT 1A agonists and partial agonists on open/total arm entry ratio (OTR) have been examined in the elevated X-maze anxiety model. 8-OH-DPAT (0.05–0.2 mg/kg), RU 24969 (0.5–2.0 mg/kg) and BAY R 1521 (0.1–1.2 mg/kg) produced dose-dependent reductions in OTR, signifying anxiogenic effects. Buspirone reduced OTR only at doses (0.25–5.0 mg/kg) decreasing total entries; gepirone (0.1–5.0 mg/kg) was inactive. Ipsapirone (0.25–5.0 mg/kg) increased OTR and at 1.0 mg/kg antagonised the anxiogenic action of 8-OH-D-PAT, RU 24969 and BAY R 1531. Gepirone (2.5 mg/kg) failed to antagonise 8-OH-DPAT, but the dose was limited by its effect on total entries. The anxiogenic effect of a low dose of 8-OH-DPAT was also prevented by p -chlorophenylalanine ( p -CPA) pretreatment and reversed to anxiolytic by 5,7-dihydroxytryptamine lesions of dorsal raphe, which spared median raphe. These lesions also abolished the anxiolytic effect of ipsapirone without affecting the anxiogenic response to yohimbine. This study provides preliminary evidence that 8-OH-DPAT may be capable of acting as an agonist and ipsapirone as an antagonist at a presynaptic site related to dorsal raphe which is separate from the site of action of yohimbine. 5-HT 1A agonists and partial agonists may have multiple sites and/or mechanisms of action in the elevated X-maze.
Psychopharmacology – Springer Journals
Published: Apr 1, 1992
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