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C. Fernandes, S. File (1999)
Dizocilpine does not prevent the development of tolerance to the anxiolytic effects of diazepam in ratsBrain Research, 815
J. Crawley, P. Marangos, J. Stivers, F. Goodwin (1982)
Chronic clonazepam administration induced benzodiazepine receptor subsensitivityNeuropharmacology, 21
R. Holt, I. Martin, A. Bateson (1997)
Chronic diazepam exposure decreases transcription of the rat GABAA receptor γ2-subunit geneMolecular Brain Research, 48
L. Gonzalez, N. Andrews, S. File (1996)
5-HT1A and benzodiazepine receptors in the basolateral amygdala modulate anxiety in the social interaction test, but not in the elevated plus-mazeBrain Research, 732
R. Brett, R. Brett, Judith Pratt, Judith Pratt (1995)
Changes in benzodiazepine‐GABA receptor coupling in an accumbens‐habenula circuit after chronic diazepam treatmentBritish Journal of Pharmacology, 116
E. Sandra (1989)
Chronic diazepam treatment: Effect of dose on development of tolerance and incidence of withdrawal in an animal test of anxietyHuman Psychopharmacology: Clinical and Experimental, 4
S. File, L. Gonzalez, N. Andrews (1998)
Endogenous acetylcholine in the dorsal hippocampus reduces anxiety through actions on nicotinic and muscarinic1 receptors.Behavioral neuroscience, 112 2
R. Andreatini, J. Leite (1994)
Effect of valepotriates on the behavior of rats in the elevated plus-maze during diazepam withdrawal.European journal of pharmacology, 260 2-3
H. Rosenberg, S. Smith, T. Chiu (1983)
Benzodiazepine--specific and nonspecific tolerance following chronic flurazepam treatment.Life sciences, 32 3
Gallager Dw, Primus Rj (1993)
Benzodiazepine tolerance and dependence: GABAA receptor complex locus of change.Biochemical Society Symposia, 59
S. File, S. Pellow (1987)
Behavioral pharmacology of minor tranquilizers.Pharmacology & therapeutics, 35 3
S. Rezazadeh, P. Prather, M. Emmett-Oglesby, H. Lal (1992)
Evaluation of Anxiolytic Action of Ondansetron in Rats during Withdrawal from Chronic ChlordiazepoxideAnnals of the New York Academy of Sciences, 654
M. Davis, D. Gallager (1988)
Continuous slow release of low levels of diazepam produces tolerance to its depressant and anxiolytic effects on the startle reflex.European journal of pharmacology, 150 1-2
(1993)
Biology of benzodiazepine dependence
(1989)
Benzodiazepines in profile
R. Holt, A. Bateson, I. Martin (1996)
Chronic Treatment with Diazepam or Abecarnil Differentially Affects the Expression of GABAA Receptor Subunit mRNAs in the Rat CortexNeuropharmacology, 35
S. File, H. Baldwin, K. Aranko (1987)
Anxiogenic effects in benzodiazepine withdrawal are linked to the development of toleranceBrain Research Bulletin, 19
I. Kang, L. Miller (1991)
Decreased GABAA receptor subunit mRNA concentrations following chronic lorazepam administrationBritish Journal of Pharmacology, 103
S. File (1990)
The history of benzodiazepine dependence: A review of animal studiesNeuroscience & Biobehavioral Reviews, 14
S. File (1984)
Behavioural pharmacology of benzodiazepinesProgress in Neuro-Psychopharmacology and Biological Psychiatry, 8
(1989)
Changes in anxiety in rats tolerant to , and withdrawn from , benzodiazepines : behavioural and biochemical studies
N. Andrews, S. File, C. Fernandes, L. Gonzalez, N. Barnes (1997)
Evidence that the median raphé nucleus – dorsal hippocampal pathway mediates diazepam withdrawal-induced anxietyPsychopharmacology, 130
D. Treit (1985)
Evidence that tolerance develops to the anxiolytic effect of diazepam in ratsPharmacology Biochemistry and Behavior, 22
J. Pratt, R. Brett, D. Laurie (1998)
Benzodiazepine Dependence: From Neural Circuits to Gene ExpressionPharmacology Biochemistry and Behavior, 59
(1995)
Rat brain monoamine - oxidase - A and monoamine - oxidase - B inhibitory ( tribulin ) activity during drug - withdrawal anxiety
D. Gallager, R. Primus (1993)
Benzodiazepine tolerance and dependence: GABAA receptor complex locus of change.Biochemical Society symposium, 59
(1992)
Behavioural detection of anxiolytic action
S. Pellow, P. Chopin, S. File, M. Briley (1985)
Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the ratJournal of Neuroscience Methods, 14
S. File, L. Gonzalez (1996)
Anxiolytic effects in the plus-maze of 5-HT1A-receptor ligands in dorsal raphé and ventral hippocampusPharmacology Biochemistry and Behavior, 54
(1989)
Flumazenil prevents the development of chlordiazepoxide withdrawal in the social interaction test of anxiety
V. Tanay, T. Glencorse, A. Greenshaw, G. Baker, A. Bateson (1996)
Chronic Administration of Antipanic Drugs Alters Rat Brainstem GABAA Receptor Subunit mRNA LevelsNeuropharmacology, 35
S. File, L. Gonzalez, N. Andrews (1996)
Comparative Study of Pre- and Postsynaptic 5-HT1AReceptor Modulation of Anxiety in Two Ethological Animal TestsThe Journal of Neuroscience, 16
(1995)
Adaptive processes regulating tolerance to behavioural effects of drugs
S. File (1980)
The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugsJournal of Neuroscience Methods, 2
B. Costall, B. Jones, M. Kelly, R. Naylor, N. Oakley, E. Onaivi, M. Tyers (1989)
The effects of ondansetron (GR38032F) in rats and mice treated subchronically with diazepamPharmacology Biochemistry and Behavior, 34
C. Fernandes, S. File, D. Berry (1996)
Evidence against oppositional and pharmacokinetic mechanisms of tolerance to diazepam's sedative effectsBrain Research, 734
Rationale: Chronic treatment with benzodiazepines results in tolerance to their sedative and anxiolytic effects and there is considerable evidence that different mechanisms underlie the development of tolerance to different behavioural effects. Objective: The purpose of the present experiment was to compare the behavioural effects of chronic treatment with diazepam (15 mg/kg per day) given as daily subcutaneous injections or by osmotic minipump. Both regimens resulted in continual receptor occupancy, but the daily injections also provided a period of higher brain concentrations. Methods: Rats were tested in the holeboard, which provides measures of exploration and locomotor activity, and in the elevated plus-maze and social interaction tests of anxiety. For those in the subcutaneous injection group the tests were 2 h after injection, when brain concentrations were highest. Results: Despite a higher brain concentration in the injected group, both groups showed tolerance to diazepam’s sedative effects, after 7 days of treatment. In contrast, in the elevated plus-maze, there was tolerance to the anxiolytic effects in the pump group after 14 days, but a persisting anxiolytic effect in the injected group at 14 and 28 days. Whilst higher brain concentrations could explain this result in the plus-maze, they cannot account for the pattern observed in the social interaction test, where the injection group showed a significant anxiogenic effect at 28 days. Conclusions: Whereas the mechanism underlying tolerance to the sedative effects of diazepam was insensitive to the different treatment regimens, the results suggest that different adaptive mechanisms were triggered in the two tests of anxiety with a differential sensitivity to the treatment regimen. The adaptive mechanism predominating in the social interaction test was favoured by the injection regimen which produced intermittent peak concentrations. This mechanism seems to be an oppositional one, leading to an anxiogenic response, which was manifest despite high brain concentrations of diazepam at the time of testing.
Psychopharmacology – Springer Journals
Published: Aug 1, 1999
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