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in U.S.A. Zentrum fiir Molekulare Universit&t Hamburg, Neurobiologie, Institut fiir Neurale Signalverarbeitung, Hamburg, Federal Republic Germany I. Introduction .......................................................................................... II. Cloning Characterization Channel Superfamily ................................. A. Shaker ....................................................................... B. Shaker channel inactivation ...................................................................... C. Shaker channel gating ............................................................................ D. Shaker channel selectivity ........................................................................ E. channel gene family in DrosophiZa ................................................... F. channel families in vertebrates ....................................................... G. Novel properties vertebrate A-type ................................................. III. Pharmacology Cloned ....................................................... A. Tetraethylammonium ............................................................................. B. Charybdotoxin .................................................................................... C. Dendrotoxin ....................................................................................... IV. Structural Model Channel ............................................................. V. Identified Native .......................................... A. Shaker ....................................................................... B. in lymphocytes .............................................................. C. in pituitary .................................................................. D. Native in heart .............................................................. VI. Human Channel Genes ................................................................... VII. Concluding Remarks ................................................................................. INTRODUCTION S69 s70 s70 s70 s72 s74 s74 s75 s77 s77 S78 s79 S80 S81 S82 S82 S83 S83 S83 S84 S84 The idea that outward currents underlie the repolarization action potentials originates from the now classical electrophysiological studies Hodgkin Huxley (34). They proposed that depolarization a membrane leads to a delayed activation rectifying currents. The purpose these currents is to repolarize the membrane. Hence, the through which these repolarizing outward currents flow were termed delayed rectifier . These are selective for K ions which permeate the pore the
Physiological Reviews – The American Physiological Society
Published: Oct 1, 1992
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