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Oxidative Stress and Advancing Age: Results in Healthy Centenarians

Oxidative Stress and Advancing Age: Results in Healthy Centenarians OBJECTIVE: Our study aims at investigating the degree of oxidative stress in centenarians DESIGN: Indices of oxidative stress (reaction products of malondialdehyde with thiobarbituric acid (TBARS) and lipid hydroperoxides (LPO)), and plasma concentrations of antioxidant defenses (plasma vitamin E and C concentrations and reduced/oxidized glutathione ratio (GSH/GSSG)) were determined. SUBJECTS: Eighty‐two subjects volunteered for the study. They were divided into three groups: (1) adults (< 50 years of age, n = 30); (2) aged subjects (70–99 years, n = 30); (3) centenarians (age ≥ 100 years, n = 22). MEASUREMENTS: TBARS and LPO, plasma vitamin E and C concentrations, and plasma GSH/GSSG ratio were determined. Insulin action was assessed by euglycemic hyperinsulinemic glucose clamp. MAIN RESULTS: TBARS (0.44±0.07 vs 0.31 ±.05 nmol malondialdehyde/mL plasma, P =.020) and LPO (0.36 ± 0.05 vs 0.31 ±.04 μmol/L, P =.050) were lower in centenarians than in aged subjects. In contrast, plasma GSH/GSSG ratio (0.82 ± 0.09 vs 1.17 ±.06, P =.010), vitamin C (72.3 ± 4.6 vs 59.4 ± 3.8 μmol/L P =.010), and vitamin E (29.1 ± 2.2 vs 24.4 ± 2.3 μmol/L P =.050) concentrations were more elevated in centenarians than in aged subjects. Differences in daily vegetable intake, in fasting plasma glucose and free fatty acid (FFA) concentrations, and in insulin action are significant determinants of degree of oxidative stress. A specific genetic background in centenarians might also provide a possible explanation. CONCLUSIONS: The degree of oxidative stress is lower in healthy centenarians than in aged subjects. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of American Geriatrics Society Wiley

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References (36)

Publisher
Wiley
Copyright
1998 The American Geriatrics Society
ISSN
0002-8614
eISSN
1532-5415
DOI
10.1111/j.1532-5415.1998.tb02716.x
Publisher site
See Article on Publisher Site

Abstract

OBJECTIVE: Our study aims at investigating the degree of oxidative stress in centenarians DESIGN: Indices of oxidative stress (reaction products of malondialdehyde with thiobarbituric acid (TBARS) and lipid hydroperoxides (LPO)), and plasma concentrations of antioxidant defenses (plasma vitamin E and C concentrations and reduced/oxidized glutathione ratio (GSH/GSSG)) were determined. SUBJECTS: Eighty‐two subjects volunteered for the study. They were divided into three groups: (1) adults (< 50 years of age, n = 30); (2) aged subjects (70–99 years, n = 30); (3) centenarians (age ≥ 100 years, n = 22). MEASUREMENTS: TBARS and LPO, plasma vitamin E and C concentrations, and plasma GSH/GSSG ratio were determined. Insulin action was assessed by euglycemic hyperinsulinemic glucose clamp. MAIN RESULTS: TBARS (0.44±0.07 vs 0.31 ±.05 nmol malondialdehyde/mL plasma, P =.020) and LPO (0.36 ± 0.05 vs 0.31 ±.04 μmol/L, P =.050) were lower in centenarians than in aged subjects. In contrast, plasma GSH/GSSG ratio (0.82 ± 0.09 vs 1.17 ±.06, P =.010), vitamin C (72.3 ± 4.6 vs 59.4 ± 3.8 μmol/L P =.010), and vitamin E (29.1 ± 2.2 vs 24.4 ± 2.3 μmol/L P =.050) concentrations were more elevated in centenarians than in aged subjects. Differences in daily vegetable intake, in fasting plasma glucose and free fatty acid (FFA) concentrations, and in insulin action are significant determinants of degree of oxidative stress. A specific genetic background in centenarians might also provide a possible explanation. CONCLUSIONS: The degree of oxidative stress is lower in healthy centenarians than in aged subjects.

Journal

Journal of American Geriatrics SocietyWiley

Published: Jul 1, 1998

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