Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Shibata, K. Yoshimura, Hirosumi Tamura, T. Ueno, Taki Nishimura, Takao Inoue, M. Sasaki, M. Koike, H. Arai, E. Kominami, Y. Uchiyama (2010)
LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation.Biochemical and biophysical research communications, 393 2
J. Houlihan, Jennifer Metzler, J. Blum (2009)
HSP90α and HSP90β Isoforms Selectively Modulate MHC Class II Antigen Presentation in B Cells1The Journal of Immunology, 182
S. Dissanayake, Natalia Tuera, S. Ostrand-Rosenberg (2005)
Presentation of Endogenously Synthesized MHC Class II-Restricted Epitopes by MHC Class II Cancer Vaccines Is Independent of Transporter Associated with Ag Processing and the Proteasome1The Journal of Immunology, 174
N. Mizushima, T. Yoshimori, B. Levine (2010)
Methods in Mammalian Autophagy ResearchCell, 140
Susmita Kaushik, A. Massey, N. Mizushima, A. Cuervo (2008)
Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy.Molecular biology of the cell, 19 5
Serhiy Pankiv, T. Clausen, T. Lamark, A. Brech, J. Bruun, Heidi Outzen, Aud Øvervatn, G. Bjørkøy, T. Johansen (2007)
p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy*Journal of Biological Chemistry, 282
M. Kasai, I. Tanida, T. Ueno, E. Kominami, S. Seki, T. Ikeda, T. Mizuochi (2009)
Autophagic Compartments Gain Access to the MHC Class II Compartments in Thymic EpitheliumThe Journal of Immunology, 183
Yiyu Zheng, Shahab Shahnazari, A. Brech, T. Lamark, T. Johansen, J. Brumell (2009)
The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway1The Journal of Immunology, 183
Brian Miller, Zijiang Zhao, L. Stephenson, K. Cadwell, Heather Pua, H. Lee, N. Mizushima, A. Iwasaki, You-Wen He, W. Swat, Herbert IV (2008)
The autophagy gene ATG5 plays an essential role in B lymphocyte developmentAutophagy, 4
A. Tsang, Kirsten Oestergaard, Jesse Myers, J. Swanson (2000)
Altered membrane trafficking in activated bone marrow‐derived macrophagesJournal of Leukocyte Biology, 68
L. Travassos, L. Carneiro, Mahendrasingh Ramjeet, S. Hussey, Yun-Gi Kim, J. Magalhaes, L. Yuan, F. Soares, Evelyn Chea, L. Bourhis, I. Boneca, A. Allaoui, N. Jones, G. Núñez, S. Girardin, D. Philpott (2010)
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entryNature Immunology, 11
M. Tal, A. Iwasaki (2009)
Autophagy and innate recognition systems.Current topics in microbiology and immunology, 335
J. Kunz, H. Schwarz, A. Mayer (2004)
Determination of Four Sequential Stages during Microautophagy in Vitro*Journal of Biological Chemistry, 279
C. Jagannath, Devin Lindsey, S. Dhandayuthapani, Yi Xu, R. Hunter, N. Eissa (2009)
Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cellsNature Medicine, 15
M. Kundu, T. Lindsten, Chia-Ying Yang, Junmin Wu, F. Zhao, Ji Zhang, M. Selak, P. Ney, C. Thompson (2008)
Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation.Blood, 112 4
Luca Jahreiss, Fiona Menzies, D. Rubinsztein (2008)
The Itinerary of Autophagosomes: From Peripheral Formation to Kiss-and-Run Fusion with LysosomesTraffic (Copenhagen, Denmark), 9
A. Riedel, F. Nimmerjahn, S. Burdach, U. Behrends, G. Bornkamm, J. Mautner (2008)
Endogenous presentation of a nuclear antigen on MHC class II by autophagy in the absence of CRM1‐mediated nuclear exportEuropean Journal of Immunology, 38
D. Jaraquemada, M. Martı́, Eric Long (1990)
An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cellsThe Journal of Experimental Medicine, 172
H. Virgin, B. Levine (2009)
Autophagy genes in immunityNature Immunology, 10
D. Dörfel, S. Appel, F. Grünebach, M. Weck, Martin Müller, A. Heine, P. Brossart (2005)
Processing and presentation of HLA class I and II epitopes by dendritic cells after transfection with in vitro-transcribed MUC1 RNA.Blood, 105 8
Martin Uhl, Martin Uhl, O. Kepp, O. Kepp, O. Kepp, H. Jusforgues-Saklani, H. Jusforgues-Saklani, J. Vicencio, J. Vicencio, J. Vicencio, Guido Kroemer, Guido Kroemer, Guido Kroemer, Albert Ml, Albert Ml, Albert Ml (2009)
Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cellsCell Death and Differentiation, 16
M. Malnati, S. Ceman, M. Weston, R. Demars, Eric Long (1993)
Presentation of cytosolic antigen by HLA-DR requires a function encoded in the class II region of the MHC.Journal of immunology, 151 12
Casper Paludan, D. Schmid, M. Landthaler, M. Vockerodt, D. Kube, T. Tuschl, C. Münz (2005)
Endogenous MHC Class II Processing of a Viral Nuclear Antigen After AutophagyScience, 307
F. Nimmerjahn, S. Milosevic, U. Behrends, E. Jaffee, D. Pardoll, G. Bornkamm, J. Mautner (2003)
Major histocompatibility complex class II‐restricted presentation of a cytosolic antigen by autophagyEuropean Journal of Immunology, 33
A. Massey, Cong Zhang, A. Cuervo (2006)
Chaperone-mediated autophagy in aging and disease.Current topics in developmental biology, 73
K. Schroder, P. Hertzog, T. Ravasi, D. Hume (2004)
Interferon-gamma: an overview of signals, mechanisms and functions.Journal of leukocyte biology, 75 2
C. Leung, T. Haigh, Laura Mackay, A. Rickinson, G. Taylor (2010)
Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope displayProceedings of the National Academy of Sciences, 107
M. Sanjuán, C. Dillon, S. Tait, S. Moshiach, F. Dorsey, Samuel Connell, M. Komatsu, Keiji Tanaka, J. Cleveland, S. Withoff, D. Green (2007)
Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosisNature, 450
A. Simonsen, S. Tooze (2009)
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexesThe Journal of Cell Biology, 186
M. Gutierrez, Sharon Master, Sudha Singh, G. Taylor, M. Colombo, V. Deretic (2004)
Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected MacrophagesCell, 119
M. Raghavan, Natasha Cid, Syed Rizvi, L. Peters (2008)
MHC class I assembly: out and about.Trends in immunology, 29 9
Delu Zhou, J. Blum (2004)
Presentation of cytosolic antigens via MHC class II moleculesImmunologic Research, 30
S. Amigorena, A. Savina (2010)
Intracellular mechanisms of antigen cross presentation in dendritic cells.Current opinion in immunology, 22 1
(2007)
: caution in the interpretation of LC 3 localization
J. Donaldson, David Williams (2009)
Intracellular Assembly and Trafficking of MHC Class I MoleculesTraffic, 10
Cong Zhang, A. Cuervo (2008)
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic functionNature Medicine, 14
Akiko Kuma, M. Matsui, N. Mizushima (2007)
LC3, an Autophagosome Marker, Can be Incorporated into Protein Aggregates Independent of Autophagy: Caution in the Interpretation of LC3 LocalizationAutophagy, 3
Luc English, Magali Chemali, Johanne Duron, Christiane Rondeau, Annie Laplante, D. Gingras, D. Alexander, D. Leib, C. Norbury, R. Lippé, M. Desjardins (2009)
Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infectionNature Immunology, 10
Zhifen Yang, D. Klionsky (2009)
An overview of the molecular mechanism of autophagy.Current topics in microbiology and immunology, 335
R. Chicz, R. Urban, J. Gorga, D. Vignali, William Lane, J. Strominger (1993)
Specificity and promiscuity among naturally processed peptides bound to HLA-DR allelesThe Journal of Experimental Medicine, 178
C. Watts, M. West, R. Zaru (2010)
TLR signalling regulated antigen presentation in dendritic cells.Current opinion in immunology, 22 1
G. Taylor, H. Long, T. Haigh, M. Larsen, J. Brooks, A. Rickinson (2006)
A Role for Intercellular Antigen Transfer in the Recognition of EBV-Transformed B Cell Lines by EBV Nuclear Antigen-Specific CD4+ T Cells1The Journal of Immunology, 177
V. Korkhov (2009)
GFP-LC3 labels organised smooth endoplasmic reticulum membranes independently of autophagyJournal of Cellular Biochemistry, 107
C. Münz (2009)
Enhancing immunity through autophagy.Annual review of immunology, 27
S. Jacobson, R. Sékaly, C. Jacobson, H. McFarland, Eric Long (1989)
HLA class II-restricted presentation of cytoplasmic measles virus antigens to cytotoxic T cellsJournal of Virology, 63
N. Mizushima, B. Levine, A. Cuervo, D. Klionsky (2008)
Autophagy fights disease through cellular self-digestionNature, 451
R. Cooney, J. Baker, O. Brain, B. Danis, T. Pichulik, P. Allan, D. Ferguson, B. Campbell, D. Jewell, A. Simmons (2010)
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentationNature Medicine, 16
K. Schroder, P. Hertzog, T. Ravasi, D. Hume (2004)
Interferon‐γ: an overview of signals, mechanisms and functionsJournal of Leukocyte Biology, 75
M. Parkes, J. Barrett, N. Prescott, M. Tremelling, C. Anderson, S. Fisher, R. Roberts, E. Nimmo, Fraser Cummings, D. Soars, H. Drummond, C. Lees, S. Khawaja, R. Bagnall, D. Burke, Catherine Todhunter, Tariq Ahmad, Clive Onnie, W. McArdle, D. Strachan, G. Bethel, C. Bryan, C. Lewis, P. Deloukas, A. Forbes, J. Sanderson, D. Jewell, J. Satsangi, J. Mansfield, L. Cardon, C. Mathew (2007)
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibilityNature Genetics, 39
Y. Nishida, Satoko Arakawa, Kenji Fujitani, Hirofumi Yamaguchi, Takeshi Mizuta, T. Kanaseki, M. Komatsu, K. Otsu, Y. Tsujimoto, S. Shimizu (2009)
Discovery of Atg5/Atg7-independent alternative macroautophagyNature, 461
Sudha Singh, Alexander Davis, G. Taylor, V. Deretic (2006)
Human IRGM Induces Autophagy to Eliminate Intracellular MycobacteriaScience, 313
Heather Pua, I. Dzhagalov, Mariana Chuck, N. Mizushima, You-Wen He (2007)
A critical role for the autophagy gene Atg5 in T cell survival and proliferationThe Journal of Experimental Medicine, 204
Rongfu Wang, Xiang Wang, Alicia Atwood, S. Topalian, Steven Rosenberg (1999)
Cloning genes encoding MHC class II-restricted antigens: mutated CDC27 as a tumor antigen.Science, 284 5418
D. Hunt, H. Michel, Tracey Dickinson, J. Shabanowitz, A. Cox, K. Sakaguchi, E. Appella, H. Grey, A. Sette (1992)
Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad.Science, 256 5065
D. Klionsky, H. Abeliovich, P. Agostinis, D. Agrawal, G. Aliev, D. Askew, M. Baba, E. Baehrecke, B. Bahr, A. Ballabio, B. Bamber, D. Bassham, E. Bergamini, Xiaoning Bi, M. Biard-Piechaczyk, J. Blum, D. Bredesen, J. Brodsky, J. Brumell, U. Brunk, W. Bursch, N. Camougrand, E. Cebollero, F. Cecconi, Yingyu Chen, L. Chin, A. Choi, C. Chu, Jongkyeong Chung, P. Clarke, R. Clark, S. Clarke, C. Clavé, J. Cleveland, P. Codogno, M. Colombo, A. Coto-Montes, J. Cregg, A. Cuervo, Jayanta Debnath, F. Demarchi, P. Dennis, P. Dennis, V. Deretic, R. Devenish, F. Sano, J. Dice, M. Difiglia, S. Dinesh-Kumar, C. Distelhorst, M. Djavaheri-Mergny, F. Dorsey, W. Dröge, M. Dron, W. Dunn, M. Duszenko, N. Eissa, Z. Elazar, A. Esclatine, E. Eskelinen, L. Fésüs, K. Finley, J. Fuentes, J. Fueyo, K. Fujisaki, B. Galliot, F. Gao, D. Gewirtz, S. Gibson, A. Gohla, A. Goldberg, R. Gonzalez, Cristina González-Estévez, S. Gorski, R. Gottlieb, D. Häussinger, You-Wen He, K. Heidenreich, Joseph Hill, M. Høyer-Hansen, Xun Hu, Wei‐Pang Huang, A. Iwasaki, M. Jäättelä, W. Jackson, Xuejun Jiang, Shengkan Jin, T. Johansen, Jae Jung, M. Kadowaki, Chanhee Kang, A. Kelekar, D. Kessel, J. Kiel, Hong-pyo Kim, A. Kimchi, T. Kinsella, K. Kiselyov, K. Kitamoto, E. Knecht, M. Komatsu, E. Kominami, S. Kondo, A. Kovács, G. Kroemer, C. Kuan, Rakesh Kumar, M. Kundu, J. Landry, M. Laporte, W. Le, H. Lei, M. Lenardo, B. Levine, A. Lieberman, K. Lim, F. Lin, Willisa Liou, Leroy Liu, G. Lopez-Berestein, C. López-Otín, Bo Lu, K. Macleod, W. Malorni, W. Martinet, K. Matsuoka, J. Mautner, A. Meijer, A. Meléndez, P. Michels, G. Miotto, W. Mistiaen, N. Mizushima, B. Mograbi, Iryna Monastyrska, Michael Moore, P. Moreira, Y. Moriyasu, T. Motyl, C. Münz, Leon Murphy, Naweed Naqvi, T. Neufeld, I. Nishino, R. Nixon, T. Noda, B. Nürnberg, Michinaga Ogawa, N. Oleinick, L. Olsen, B. Ozpolat, S. Paglin, G. Palmer, I. Papassideri, M. Parkes, D. Perlmutter, George Perry, M. Piacentini, R. Pinkas-Kramarski, M. Prescott, T. Proikas-Cezanne, N. Raben, A. Rami, F. Reggiori, B. Rohrer, D. Rubinsztein, K. Ryan, J. Sadoshima, H. Sakagami, Y. Sakai, M. Sandri, C. Sasakawa, M. Sass, C. Schneider, P. Seglen, O. Seleverstov, J. Settleman, J. Shacka, I. Shapiro, A. Sibirny, E. Silva-Zacarin, H. Simon, C. Simone, A. Simonsen, Mark Smith, K. Spanel‐borowski, V. Srinivas, Meredith Steeves, H. Stenmark, P. Strømhaug, C. Subauste, S. Sugimoto, D. Sulzer, Toshihiko Suzuki, M. Swanson, I. Tabas, F. Takeshita, N. Talbot, Z. Tallóczy, Keiji Tanaka, Kozo Tanaka, I. Tanida, G. Taylor, J. Taylor, A. Terman, Gianluca Tettamanti, C. Thompson, M. Thumm, A. Tolkovsky, S. Tooze, R. Truant, L. Tumanovska, Y. Uchiyama, T. Ueno, Néstor Uzcátegui, I. Klei, E. Vaquero, T. Vellai, Michael Vogel, Hong-Gang Wang, P. Webster, J. Wiley, Z. Xi, G. Xiao, J. Yahalom, Jin-Ming Yang, G. Yap, Xiao-Ming Yin, T. Yoshimori, Li Yu, Zhenyu Yue, M. Yuzaki, O. Zabirnyk, Xiaoxiang Zheng, Xiongwei Zhu, R. Deter (2008)
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotesAutophagy, 4
J. Lich, J. Elliott, J. Blum (2000)
Cytoplasmic Processing Is a Prerequisite for Presentation of an Endogenous Antigen by Major Histocompatibility Complex Class II ProteinsThe Journal of Experimental Medicine, 191
D. Schmid, M. Pypaert, C. Münz (2007)
Antigen-loading compartments for major histocompatibility complex class II molecules continuously receive input from autophagosomes.Immunity, 26 1
N. Mizushima, A. Yamamoto, M. Matsui, T. Yoshimori, Y. Ohsumi (2003)
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker.Molecular biology of the cell, 15 3
C. Feng, Lixin Zheng, D. Jankovic, A. Báfica, J. Cannons, W. Watford, D. Chaussabel, S. Hieny, P. Caspar, P. Schwartzberg, M. Lenardo, A. Sher (2008)
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-γ-induced cell deathNature Immunology, 9
M. Krawczyk, Elisa Leimgruber, Queralt Seguín-Estévez, I. Dunand-Sauthier, E. Barras, W. Reith (2006)
Expression of RAB4B, a protein governing endocytic recycling, is co-regulated with MHC class II genesNucleic Acids Research, 35
P. Mukherjee, Aadish Dani, S. Bhatia, Nagendra Singh, A. Rudensky, A. George, V. Bal, S. Mayor, S. Rath (2001)
Efficient Presentation of Both Cytosolic and Endogenous Transmembrane Protein Antigens on MHC Class II Is Dependent on Cytoplasmic Proteolysis1The Journal of Immunology, 167
Doktorgrades Naturwissenschaften (2009)
Autophagy in Thymic Epithelium Shapes the T cell Repertoire and is Essential for Tolerance
Heather Pua, Jian Guo, M. Komatsu, You-Wen He (2009)
Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes1The Journal of Immunology, 182
H. Lee, Lisa Mattei, B. Steinberg, P. Alberts, Yun-Hee Lee, A. Chervonsky, N. Mizushima, S. Grinstein, A. Iwasaki (2010)
In vivo requirement for Atg5 in antigen presentation by dendritic cells.Immunity, 32 2
Zijiang Zhao, B. Fux, Megan Goodwin, I. Dunay, D. Strong, Brian Miller, K. Cadwell, Mônica Delgado, Marisa Ponpuak, K. Green, R. Schmidt, N. Mizushima, V. Deretic, L. Sibley, H. Virgin (2008)
Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular PathogensCell Host & Microbe, 4
Delu Zhou, Ping Li, Yinling Lin, Jeremy Lott, A. Hislop, D. Canaday, R. Brutkiewicz, J. Blum (2005)
Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens.Immunity, 22 5
A. Dongre, S. Kovats, P. Deroos, A. McCormack, T. Nakagawa, V. Paharkova-Vatchkova, J. Eng, H. Caldwell, John III, A. Rudensky (2001)
In vivo MHC class II presentation of cytosolic proteins revealed by rapid automated tandem mass spectrometry and functional analysesEuropean Journal of Immunology, 31
L. Ramachandra, D. Simmons, C. Harding (2009)
MHC molecules and microbial antigen processing in phagosomes.Current opinion in immunology, 21 1
Bo Li, Z. Lei, B. Lichty, Dong Li, Gui-mei Zhang, Zuo-hua Feng, Y. Wan, Bo Huang (2010)
Autophagy facilitates major histocompatibility complex class I expression induced by IFN-γ in B16 melanoma cellsCancer Immunology, Immunotherapy, 59
Yuhuan Li, Li-xin Wang, Guojun Yang, Fang Hao, W. Urba, Hong-Ming Hu (2008)
Efficient cross-presentation depends on autophagy in tumor cells.Cancer research, 68 17
L. Klein, M. Hinterberger, Gerald Wirnsberger, B. Kyewski (2009)
Antigen presentation in the thymus for positive selection and central tolerance inductionNature Reviews Immunology, 9
Nuno Rocha, J. Neefjes (2008)
MHC class II molecules on the move for successful antigen presentationThe EMBO Journal, 27
W. Beertsen, M. Willenborg, V. Everts, Angelika Zirogianni, R. Podschun, B. Schröder, E. Eskelinen, P. Saftig (2008)
Impaired Phagosomal Maturation in Neutrophils Leads to Periodontitis in Lysosomal-Associated Membrane Protein-2 Knockout Mice1The Journal of Immunology, 180
J. Dengjel, O. Schoor, R. Fischer, Michael Reich, M. Kraus, Margret Müller, Katharina Kreymborg, F. Altenberend, J. Brandenburg, H. Kalbacher, R. Brock, C. Driessen, H. Rammensee, S. Stevanović (2005)
Autophagy promotes MHC class II presentation of peptides from intracellular source proteinsProceedings of the National Academy of Sciences of the United States of America, 102
Summary Autophagy plays an important role in maintaining intracellular homeostasis by promoting the transit of cytoplasmic material, such as proteins, organelles and pathogens, for degradation within acidic organelles. Yet, in immune cells, autophagy pathways serve an additional role in facilitating intracellular surveillance for pathogens and changes in self. Autophagy pathways can modulate key steps in the development of innate and adaptive immunity. In terms of adaptive immunity, autophagy regulates the development and survival of lymphocytes as well as the modulation of antigen processing and presentation. Specialized forms of autophagy may be induced by some viral pathogens, providing a novel route for major histocompatibility complex (MHC) class I antigen presentation and enhanced CD8+ T‐cell responses. Autophagy induction in target cells also increases their potential to serve as immunogens for dendritic cell cross‐presentation to CD8+ T cells. The requirement for autophagy in MHC class II presentation of cytoplasmic and nuclear antigens is well established, yet recent studies also point to a critical role for autophagy in modulating CD4+ T‐cell responses to phagocytosed pathogens. Autophagy pathways can also modulate the selection and survival of some CD4+ T cells in the thymus. However, much still remains to be learned mechanistically with respect to how autophagy and autophagy‐linked genes regulate pathogen recognition and antigen presentation, as well as the development and survival of immune cells.
Immunology – Wiley
Published: Sep 1, 2010
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.