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Nitric oxide mediating NANC inhibition in opossum lower esophageal sphincter

Nitric oxide mediating NANC inhibition in opossum lower esophageal sphincter MATERIALS METHODS NONADRENERGIC, NONCHOLINERGIC () nerves play an important role for of gastrointestinal smooth muscle, but the transmitter(s) involved in remains to be identified. In the opossum lower esophageal sphincter (LES), nerve stimulation is associated with an increase in guanosine 3’,5’-cyclic monophosphate (cGMP), while adenosine 3’,5’-cyclic monophosphate (CAMP) levels are unchanged (20). In vascular preparations, acetylcholine induces a relaxation that is dependent on the presence of an intact endothelium (4). Bioassay studies have shown that the response is mediated by a diffusible substance with a half-life of a few seconds (9). The substance, known as endothelium-derived relaxing factor (EDRF), has been shown to stimulate the guanylate cyclase, thus increasing cGMP levels (22). Other inhibitory agents acting by stimulating the guanylate cyclase include sodium nitroprusside (SNP) glyceryl trinitrate (18), while vasoactive intestinal polypeptide (VIP), a transmitter cidate (1,8), seemsto mainly stimulate the formation 0193~1857/91 $1.50 Copyright Eleven mature opossums of either sex weighing 1.93.5 kg were anesthetized with pentobarbital sodium (35 mg/kg ip). The abdomen thorax were opened the lower esophagus a proximal cuff of the stomach were removed immediately placed in ice-cold oxygenated Krebs solution (seebelow for composition). After it was opened along its longitudinal axis, the esophagus http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Gastrointestinal and Liver Physiology The American Physiological Society

Nitric oxide mediating NANC inhibition in opossum lower esophageal sphincter

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Publisher
The American Physiological Society
Copyright
Copyright © 1991 the American Physiological Society
ISSN
0193-1857
eISSN
1522-1547
Publisher site
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Abstract

MATERIALS METHODS NONADRENERGIC, NONCHOLINERGIC () nerves play an important role for of gastrointestinal smooth muscle, but the transmitter(s) involved in remains to be identified. In the opossum lower esophageal sphincter (LES), nerve stimulation is associated with an increase in guanosine 3’,5’-cyclic monophosphate (cGMP), while adenosine 3’,5’-cyclic monophosphate (CAMP) levels are unchanged (20). In vascular preparations, acetylcholine induces a relaxation that is dependent on the presence of an intact endothelium (4). Bioassay studies have shown that the response is mediated by a diffusible substance with a half-life of a few seconds (9). The substance, known as endothelium-derived relaxing factor (EDRF), has been shown to stimulate the guanylate cyclase, thus increasing cGMP levels (22). Other inhibitory agents acting by stimulating the guanylate cyclase include sodium nitroprusside (SNP) glyceryl trinitrate (18), while vasoactive intestinal polypeptide (VIP), a transmitter cidate (1,8), seemsto mainly stimulate the formation 0193~1857/91 $1.50 Copyright Eleven mature opossums of either sex weighing 1.93.5 kg were anesthetized with pentobarbital sodium (35 mg/kg ip). The abdomen thorax were opened the lower esophagus a proximal cuff of the stomach were removed immediately placed in ice-cold oxygenated Krebs solution (seebelow for composition). After it was opened along its longitudinal axis, the esophagus

Journal

AJP - Gastrointestinal and Liver Physiology – The American Physiological Society

Published: Mar 1, 1991

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