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Induction of human skeletal muscle lipoprotein lipase gene expression by short-term exercise is transient

Induction of human skeletal muscle lipoprotein lipase gene expression by short-term exercise is... Seip, Richard L., Ken Mair, Thomas G. Cole, and Clay F. Semenkovich. of human skeletal muscle lipoprotein lipase gene by short-term exercise is . Am. J. Physiol. 272 (Endocrinol. Metab. 35): E255E261, 1997.-Exercise increases skeletal muscle lipoprotein lipase (LPL) , but the time course of this response is not known. In the present study, we examined the time course of the LPL response to both short-term and acute exercise and measured circulating levels of putative regulators of muscle LPL. Nine adults underwent short-term exercise training (60-90 min of stationary cycling at 55-70% of leg ergometer peak oxygen uptake on 5 consecutive days). Five vastus lateralis biopsies were performed: before training, 20 h after the fourth bout (immediately before the 5th bout), and 0.2,4, and 8 h after the fifth bout. After four bouts of exercise in 4 days, there was no increase in LPL mass or LPL mRNA exactly 20 h after the fourth bout. However, when tissues were sampled closer to the exercise bout on the 5th day, increases were seen. On day 5, LPL mRNA increased by 127% (P < 0.05) at 4 h postexercise and was followed by an increase in LPL mass of 93% http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Induction of human skeletal muscle lipoprotein lipase gene expression by short-term exercise is transient

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Publisher
The American Physiological Society
Copyright
Copyright © 1997 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
See Article on Publisher Site

Abstract

Seip, Richard L., Ken Mair, Thomas G. Cole, and Clay F. Semenkovich. of human skeletal muscle lipoprotein lipase gene by short-term exercise is . Am. J. Physiol. 272 (Endocrinol. Metab. 35): E255E261, 1997.-Exercise increases skeletal muscle lipoprotein lipase (LPL) , but the time course of this response is not known. In the present study, we examined the time course of the LPL response to both short-term and acute exercise and measured circulating levels of putative regulators of muscle LPL. Nine adults underwent short-term exercise training (60-90 min of stationary cycling at 55-70% of leg ergometer peak oxygen uptake on 5 consecutive days). Five vastus lateralis biopsies were performed: before training, 20 h after the fourth bout (immediately before the 5th bout), and 0.2,4, and 8 h after the fifth bout. After four bouts of exercise in 4 days, there was no increase in LPL mass or LPL mRNA exactly 20 h after the fourth bout. However, when tissues were sampled closer to the exercise bout on the 5th day, increases were seen. On day 5, LPL mRNA increased by 127% (P < 0.05) at 4 h postexercise and was followed by an increase in LPL mass of 93%

Journal

AJP - Endocrinology and MetabolismThe American Physiological Society

Published: Feb 1, 1997

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