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Åkerman Åkerman, Nicholls Nicholls (1981d)
Fntra‐synaptosomal compartmentation of Ca 2+ during depolarization‐induced Ca 2+ uptake across the plasma membrane.Biochim. Biophys. Acta, 645
E. Heinonen, K. Åkerman, K. Kaila (1984)
Depolarization of the mitochondrial membrane potential increases free cytosolic calcium in synaptosomesNeuroscience Letters, 49
P. Baker, D. Knight (1978)
Calcium-dependent exocytosis in bovine adrenal medullary cells with leaky plasma membranesNature, 276
T. Sihra, D. Nicholls (1987)
4‐Aminobutyrate Can Be Released Exocytotically from Guinea‐Pig Cerebral Cortical SynaptosomesJournal of Neurochemistry, 49
Cotman Cotman, Haycock Haycock, White White (1976)
Stimulus‐secretion coupling processes in brain: analysis of noradrenaline and GABA releaseJ. Physiol. (Lond.), 254
R. Kauppinen, D. Nicholls (1986)
Synaptosomal bioenergetics. The role of glycolysis, pyruvate oxidation and responses to hypoglycaemia.European journal of biochemistry, 158 1
(1987)
influx and stimulates transmitter release in guinea-pig synaptosomes
P. Nielsen, J. Hansen, O. Buchardt (1984)
Photochemical cross-linking of protein and DNA in chromatin. Synthesis and application of a photosensitive cleavable derivative of 9-aminoacridine with two photoprobes connected through a disulphide-containing linker.The Biochemical journal, 223 2
M. Sandoval, P. Horch, C. Cotman (1978)
Evaluation of glutamate as a hippocampal neurotransmitter: Glutamate uptake and release from synaptosomesBrain Research, 142
R. Johnson, S. Carty, A. Scarpa (1981)
Proton: substrate stoichiometries during active transport of biogenic amines in chromaffin ghosts.The Journal of biological chemistry, 256 11
S. Naito, Tetsufumi Ueda (1983)
Adenosine triphosphate-dependent uptake of glutamate into protein I-associated synaptic vesicles.The Journal of biological chemistry, 258 2
D. Nicholls, M. Rugolo, I. Scott, J. Meldolesi (1982)
alpha-latrotoxin of black widow spider venom depolarizes the plasma membrane, induces massive calcium influx, and stimulates transmitter release in guinea pig brain synaptosomes.Proceedings of the National Academy of Sciences of the United States of America, 79 24
T. Sihra, I. Scott, D. Nicholls (1984)
Ionophore A23187, Verapamil, Protonophores, and Veratridine Influence the Release of γ‐Aminobutyric Acid from Synaptosomes by Modulation of the Plasma Membrane Potential Rather than the Cytosolic CalciumJournal of Neurochemistry, 43
I. Scott, D. Nicholls (1980)
Energy transduction in intact synaptosomes. Influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ.The Biochemical journal, 186 1
J. Brooks, S. Treml (1983)
Catecholamine Secretion by Chemically Skinned Cultured Chromaffm CellsJournal of Neurochemistry, 40
K. Åkerman, D. Nicholls (1981)
ATP depletion increases Ca2+ uptake by synaptosomesFEBS Letters, 135
E. Heinonen, K. Åkerman, K. Kaila, I. Scott (1985)
Dependence of cytoplasmic calcium transients on the membrane potential in isolated nerve endings of the guinea pig.Biochimica et biophysica acta, 815 2
Dunn Dunn, Holz Holz (1983)
Catecholamine secretion from digitonin‐treated adrenal medullary chromaffin cellsJ. Biol. Chem., 258
S. Naito, T. Ueda (1985)
Characterization of Glutamate Uptake into Synaptic VesiclesJournal of Neurochemistry, 44
J. Storm-Mathisen, Alfhild Leknes, Anna Bore, J. Vaaland, P. Edminson, F. Haug, O. Ottersen (1983)
First visualization of glutamate and GABA in neurones by immunocytochemistryNature, 301
( 1 983 ) A kinetic analysis of the release of acidic amino acids from rat cortical synaptosomes following pre - loading with [ ' 4 C ] - glutamic acid
P. Drapeau, M. Blaustein (1983)
Initial release of [3H]dopamine from rat striatal synaptosomes: correlation with calcium entry, 3
R. Kauppinen, D. Nicholls (1986)
Failure to Maintain Glycolysis in Anoxic Nerve TerminalsJournal of Neurochemistry, 47
I. Scott, K. Åkerman, D. Nicholls (1980)
Calcium-ion transport by intact synaptosomes. Intrasynaptosomal compartmentation and the role of the mitochondrial membrane potential.The Biochemical journal, 192 3
B. Pressman (1976)
Biological applications of ionophores.Annual review of biochemistry, 45
M. Rugolo, J. Dolly, D. Nicholls (1986)
The mechanism of action of beta-bungarotoxin at the presynaptic plasma membrane.The Biochemical journal, 233 2
K. Åkerman, D. Nicholls (2005)
Ca2+ transport by intact synaptosomes: the voltage-dependent Ca2+ channel and a re-evaluation of the role of sodium/calcium exchange.European journal of biochemistry, 117 3
R. Holz, R. Senter, R. Sharp (1983)
Evidence that the H+ electrochemical gradient across membranes of chromaffin granules is not involved in exocytosis.The Journal of biological chemistry, 258 12
C. Cotman, J. Haycock, W. White (1976)
Stimulus‐secretion coupling processes in brain: analysis of noradrenaline and gamma‐aminobutyric acid release.The Journal of Physiology, 254
Levi Levi, Gallo Gallo, Raiteri Raiteri (1980)
A re‐evaluation of veratridine as a tool for studying the depolarization‐induced release of neurotransmitters from nerve endingsNeurochem. Res., 5
M. Diebler (1982)
Acetylcholine Release from Isolated Synaptic Vesicles Related to Ionic Permeability Changes: Continuous Detection with a Chemiluminescent MethodJournal of Neurochemistry, 39
G. Levi, R. Gordon, V. Gallo, G. Wilkin, R. Bala´zs (1982)
Putative acidic amino acid transmitters in the cerebellum I. Depolarization-induced releaseBrain Research, 239
D. Nicholls, T. Sihra (1986)
Synaptosomes possess an exocytotic pool of glutamateNature, 321
K. Åkerman, D. Nicholls (1981)
Intrasynaptosomal compartmentation of calcium during depolarization-induced calcium uptake across the plasma membrane.Biochimica et biophysica acta, 645 1
Åkerman Åkerman, Nicholls Nicholls (1981b)
Ca transport by intact synaptosomes: the voltage‐dependent Ca channel and a re‐evaluation of the role of Na/Ca exchange.Eur. J. Biochem., 117
Åkerman Åkerman, Nicholls Nicholls (1981a)
Ca transport by intact synaptosomes: influence of ionophore A23187 on plasma membrane potential, plasma membrane Ca transport, mitochondrial membrane potential, cytosolic free Ca concentration and noradrenaline release.Eur. J. Biochem., 115
D. Nicholls, T. Sihra, J. Sánchez-Prieto (1987)
Calcium‐Dependent and‐Independent Release of Glutamate from Synaptosomes Monitored by Continuous FluorometryJournal of Neurochemistry, 49
Naito Naito, Ueda Ueda (1983)
ATP‐dependent uptake of glutamate into protein I‐associated synaptic vesiclesJ. Biol. Chem., 258
(1982)
Uptake of L['HI-glutamate by crude and purified synaptic vesicles from rat brain
R. Snelling, D. Nicholls (1985)
Calcium efflux and cycling across the synaptosomal plasma membrane.The Biochemical journal, 226 1
Knight Knight, Baker Baker (1985)
The chromaffin granule proton pump and Ca‐dependent exocytosis in bovine adrenal medullary cellsJ. Membr. Biol., 83
Abstract: A continuous enzyme‐linked fluorometric assay was used for determining the characteristics for glutamate exocytosis from guinea‐pig cerebrocortical synaptosomes. Ca2+‐dependent release can be induced not only by K+, but also by the Na+ channel activator veratridine and the Ca2+ ionophore ionomycin. K+‐induced release can be inhibited by the Ca2+ channel inhibitor verapamil. Sr2+ and Ba2+ substitute for Ca2+ in promoting K+‐induced release. Agents that would be predicted to transform the transvesicular pH gradient into a membrane potential are without effect on glutamate release. However, the protonophore carbonylcy‐anide p‐trifluoromethoxyphenylhydrazone causes a time‐dependent loss of exocytosis that is oligomycin insensitive and may be due to depletion of vesicular glutamate. The Ca2+‐independent release of glutamate from the cytosol on depolarization is unchanged or promoted by metabolic inhibitors that lower the ATP/ADP ratio. In contrast, Ca2+‐dependent release is ATP dependent and is blocked by the combined inhibition of oxidative phosphorylation and glycolysis.
Journal of Neurochemistry – Wiley
Published: Jul 1, 1987
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