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A. Schinder, E. Olson, N. Spitzer, M. Montal (1996)
Mitochondrial Dysfunction Is a Primary Event in Glutamate NeurotoxicityThe Journal of Neuroscience, 16
L. Pellerin, P. Magistretti (1994)
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.Proceedings of the National Academy of Sciences of the United States of America, 91 22
L. Kiedrowski, J. Wroblewski, E. Costa (1994)
Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate.Molecular pharmacology, 45 5
M. Goldberg, D. Choi (1993)
Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury, 13
RJ White, I. Reynolds (1996)
Mitochondrial Depolarization in Glutamate-Stimulated Neurons: An Early Signal Specific to Excitotoxin ExposureThe Journal of Neuroscience, 16
V. Dawson, T. Dawson, Danielle Bartley, G. Uhl, S. Snyder (1993)
Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures, 13
V. Dawson, T. Dawson, E. London, D. Bredt, S. Snyder (1991)
Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.Proceedings of the National Academy of Sciences of the United States of America, 88 14
Tai‐Wing Wu, K. Fung, L. Zeng, Jun Wu, H. Nakamura (1994)
Propyl gallate as a hepatoprotector in vitro and in vivo.Biochemical pharmacology, 48 2
F. Denizot, R. Lang (1986)
Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability.Journal of immunological methods, 89 2
M. Lafon‐Cazal, S. Pietri, M. Culcasi, J. Bockaert (1993)
NMDA-dependent superoxide production and neurotoxicityNature, 364
Shan Yu, D. Choi (1997)
Na+—Ca2+ Exchange Currents in Cortical Neurons: Concomitant Forward and Reverse Operation and Effect of GlutamateEuropean Journal of Neuroscience, 9
S. Rothman, J. Olney (1986)
Glutamate and the pathophysiology of hypoxic–ischemic brain damageAnnals of Neurology, 19
Maurice Israël, B. Lesbats, J. Bruner (1993)
Glutamate and acetylcholine release from cholinergic nerve terminals, a calcium control of the specificity of the release mechanismNeurochemistry International, 22
R. Dringen, H. Wiesinger, B. Hamprecht (1993)
Uptake of l-lactate by cultured rat brain neuronsNeuroscience Letters, 163
S. Eimerl, M. Schramm (1995)
Resuscitation of Brain Neurons in the Presence of Ca2+ After Toxic NMDA‐Receptor ActivityJournal of Neurochemistry, 65
Philippe Marin, M. Maus, S. Desagher, J. Glowinski, J. Prémont (1994)
Nicotine protects cultured striatal neurones against N-methyl-D-aspartate receptor-mediated neurotoxicity.Neuroreport, 5 15
Leonard White, Harlan Hodges, K. Carnes, J. Price, J. Dubinsky (1994)
Colocalization of excitatory and inhibitory neurotransmitter markers in striatal projection neurons in the ratJournal of Comparative Neurology, 339
(1984)
Friedreich's ataxia: intravenous pyruvate load to demonstrate a defect in pyruvate metabolism
R. Williams, M. Maus, N. Stella, J. Glowinski, J. Prémont (1996)
Reduced glucose metabolism enhances the glutamate-evoked release of arachidonic acid from striatal neuronsNeuroscience, 74
M. Mattson, M. Lovell, K. Furukawa, W. Markesbery (1995)
Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca2+ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal NeuronsJournal of Neurochemistry, 65
H. Benveniste, J. Drejer, A. Schousboe, N. Diemer (1984)
Elevation of the Extracellular Concentrations of Glutamate and Aspartate in Rat Hippocampus During Transient Cerebral Ischemia Monitored by Intracerebral MicrodialysisJournal of Neurochemistry, 43
P. Strijbos, M. Leach, J. Garthwaite (1996)
Vicious Cycle Involving Na+ Channels, Glutamate Release, and NMDA Receptors Mediates Delayed Neurodegeneration through Nitric Oxide FormationThe Journal of Neuroscience, 16
C. Théry, B. Chamak, M. Mallat (1991)
Cytotoxic Effect of Brain Macrophages on Developing NeuronsEuropean Journal of Neuroscience, 3
J Zhang, V. Dawson, T. Dawson, S. Snyder (1994)
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity.Science, 263 5147
J. Vornov (1995)
Toxic NMDA‐Receptor Activation Occurs During Recovery in a Tissue Culture Model of IschemiaJournal of Neurochemistry, 65
W. Oldendorf (1973)
Carrier-mediated blood-brain barrier transport of short-chain monocarboxylic organic acids.The American journal of physiology, 224 6
L. Dugan, S. Sensi, LM Canzoniero, SD Handran, S. Rothman, Tsai-Shiuan Lin, M. Goldberg, D. Choi (1995)
Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate, 15
S. Desagher, J. Glowinski, J. Prémont (1997)
Pyruvate Protects Neurons against Hydrogen Peroxide-Induced ToxicityThe Journal of Neuroscience, 17
Y. Izumi, A. Benz, C. Zorumski, J. Olney (1994)
Effects of lactate and pyruvate on glucose deprivation in rat hippocampal slices.Neuroreport, 5 5
Robert Williams, Nuala Murphy, J. Glowinski, J. Prémont (1995)
Glucose Regulates Glutamate‐Evoked Arachidonic Acid Release from Cultured Striatal NeuronsJournal of Neurochemistry, 65
L. Kiedrowski, E. Costa (1995)
Glutamate-induced destabilization of intracellular calcium concentration homeostasis in cultured cerebellar granule cells: role of mitochondria in calcium buffering.Molecular pharmacology, 47 1
G. Grynkiewicz, M. Poenie, Roger TsienB (1985)
A new generation of Ca2+ indicators with greatly improved fluorescence properties.The Journal of biological chemistry, 260 6
C. Zorumski, L. Thio, G. Clark, D. Clifford (1990)
Blockade of desensitization augments quisqualate excitotoxicity in hippocampal neuronsNeuron, 5
A. Conn, D. Fell, R. Steele (1983)
Characterization of alpha-keto acid transport across blood-brain barrier in rats.The American journal of physiology, 245 3
M. Ankarcrona, J. Dypbukt, E. Bonfoco, B. Zhivotovsky, S. Orrenius, S. Lipton, P. Nicotera (1995)
Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial functionNeuron, 15
J. Coyle, P. Puttfarcken (1993)
Oxidative stress, glutamate, and neurodegenerative disorders.Science, 262 5134
C. Poitry-Yamate, S. Poitry, M. Tsacopoulos (1995)
Lactate released by Muller glial cells is metabolized by photoreceptors from mammalian retina, 15
N. Murphy, J. Cordier, J. Glowinski, J. Prémont (1994)
Is Protein Kinase C Activity Required for the N‐Methyl‐d‐Aspartate‐evoked Rise in Cytosolic Ca2+ in Mouse Striatal Neurons?European Journal of Neuroscience, 6
D. Monaghan, R. Bridges, C. Cotman (1989)
The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system.Annual review of pharmacology and toxicology, 29
Marco Tsacopoulosl, P. Magistretti (1996)
Metabolic coupling between glia and neurons, 16
S. Weiss, J. Pin, M. Sebben, D. Kemp, F. Sladeczek, J. Gabrion, J. Bockaert (1986)
Synaptogenesis of cultured striatal neurons in serum-free medium: a morphological and biochemical study.Proceedings of the National Academy of Sciences of the United States of America, 83 7
JY Koh, M. Goldberg, D. Hartley, D. Choi (1990)
Non-NMDA receptor-mediated neurotoxicity in cortical culture, 10
D. Choi (1988)
Glutamate neurotoxicity and diseases of the nervous systemNeuron, 1
Kahori Yamada, C. Tang (1993)
Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents, 13
P. Paoletti, P. Ascher (1994)
Mechanosensitivity of NMDA receptors in cultured mouse central neuronsNeuron, 13
D. Hartley, D. Choi (1989)
Delayed rescue of N-methyl-D-aspartate receptor-mediated neuronal injury in cortical culture.The Journal of pharmacology and experimental therapeutics, 250 2
A sustained release of glutamate contributes to neuronal loss during cerebral ischaemia. Using cultured mouse striatal neurons, we observed that glucose deprivation, which occurs in this pathological process, enhanced the N‐Methyl‐d‐aspartate (NMDA)‐ or α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate (AMPA)‐induced neurotoxicity. The end products of glycolysis, lactate and pyruvate, strongly protected neurons from these neurotoxic effects. The neuroprotective effect of pyruvate (which is more prominent in the absence of glucose) was not related to its ability to react with H2O2 by a decarboxylation process. Pyruvate and l‐lactate strongly counteracted the deep decrease in the neuronal ATP content induced by NMDA, indicating that they might protect striatal neurons by rescuing cellular energy charge. Addition of MK‐801 after the NMDA withdrawal completely protected neurons, suggesting that NMDA neurotoxicity resulted from a delayed NMDA receptor activation probably linked to a delayed release of an endogenous agonist in the extracellular medium. The strong accumulation of extracellular glutamate which was found in both sham and NMDA‐treated cultures was markedly decreased by pyruvate. Thus, pyruvate might also exert its protecting activity by decreasing the delayed accumulation of glutamate which seemed to be neurotoxic only after a preexposure of neurons to NMDA.
European Journal of Neuroscience – Wiley
Published: Sep 1, 1999
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