Access the full text.
Sign up today, get DeepDyve free for 14 days.
L. Edvinsson, E. Ekblad, R. Håkanson, C. Wahlestedt (1984)
Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vesselsBritish Journal of Pharmacology, 83
K. Hubel (1978)
The effects of electrical field stimulation and tetrodotoxin on ion transport by the isolated rabbit ileum.The Journal of clinical investigation, 62 5
H. Sheerin, M. Field (1975)
Ileal HCO3 secretion: relationship to Na and Cl transport and effect of theophylline.The American journal of physiology, 228 4
J. Keast, J. Furness, M. Costa (1984)
Origins of peptide and norepinephrine nerves in the mucosa of the guinea pig small intestine.Gastroenterology, 86 4
Eugene Chang, Michael Field, Richard Miller (1982)
alpha 2-Adrenergic receptor regulation of ion transport in rabbit ileum.The American journal of physiology, 242 3
M. Field, I. Mccoll (1973)
Ion transport in rabbit ileal mucosa. 3. Effects of catecholamines.The American journal of physiology, 225 4
Tai (1981)
The conventional short-circuiting technique under-short-circuits most epitheliaJ. membr. Biol., 59
J. Lundberg, X. Hua, A. Franco-Cereceda (1984)
Effects of neuropeptide Y (NPY) on mechanical activity and neurotransmission in the heart, vas deferens and urinary bladder of the guinea-pig.Acta physiologica Scandinavica, 121 4
K. Tatemoto, M. Carlquist, V. Mutt (1982)
Neuropeptide Y—a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptideNature, 296
R. Chang, V. Lotti, T. Chen, D. Cerino, P. Kling (1985)
Neuropeptide Y (NPY) binding sites in rat brain labeled with 125I-Bolton-Hunter NPY: comparative potencies of various polypeptides on brain NPY binding and biological responses in the rat vas deferens.Life sciences, 37 22
J. Lundberg, K. Tatemoto, L. Terenius, P. Hellström, V. Mutt, T. Hökfelt, B. Hamberger (1982)
Localization of peptide YY (PYY) in gastrointestinal endocrine cells and effects on intestinal blood flow and motility.Proceedings of the National Academy of Sciences of the United States of America, 79 14
Furness (1984)
Choline acetyltransferase- and peptide immunoreactivity of submucous neurons in the small intestine of the guinea-pigCell Tissue Res., 237
(1983)
Distribution, pathways, and reactions
C. Schwartz, D. Kimberg, H. Sheerin, M. Field, S. Said (1974)
Vasoactive intestinal peptide stimulation of adenylate cyclase and active electrolyte secretion in intestinal mucosa.The Journal of clinical investigation, 54 3
Furness (1983)
Distribution, pathways, and reactions to drug treatment of nerves with neuropeptide Y-and pancreatic polypeptide-like immunoreactivity in the guinea pig digestive tractCell Tissue Res., 234
K. Tatemoto (1982)
Neuropeptide Y: complete amino acid sequence of the brain peptide.Proceedings of the National Academy of Sciences of the United States of America, 79 18
K. Tatemoto (1982)
Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion.Proceedings of the National Academy of Sciences of the United States of America, 79 8
K. Yamaoka, Y. Tanigawara, T. Nakagawa, T. Uno (1981)
A pharmacokinetic analysis program (multi) for microcomputer.Journal of pharmacobio-dynamics, 4 11
J. Lundberg, K. Tatemoto (1982)
Pancreatic polypeptide family (APP, BPP, NPY and PYY) in relation to sympathetic vasoconstriction resistant to alpha-adrenoceptor blockade.Acta physiologica Scandinavica, 116 4
M. Field (1971)
Ion transport in rabbit ileal mucosa. II. Effects of cyclic 3', 5'-AMP.The American journal of physiology, 221 4
M. Field, D. Fromm, I. Mccoll (1971)
Ion transport in rabbit ileal mucosa. I. Na and Cl fluxes and short-circuit current.The American journal of physiology, 220 5
M. Field (1974)
Intestinal secretion.Gastroenterology, 66 5
H. Binder, J. Laurenson, J. Dobbins (1984)
Role of opiate receptors in regulation of enkephalin stimulation of active sodium and chloride absorption.The American journal of physiology, 247 4 Pt 1
Johan Lundberg, L. Terenius, Tomas Hökfelt, Kazuhiko Tatemoto (1984)
Comparative immunohistochemical and biochemical analysis of pancreatic polypeptide-like peptides with special reference to presence of neuropeptide Y in central and peripheral neurons, 4
D. Carter, M. Vallejo, S. Lightman (1985)
Cardiovascular effects of neuropeptide Y in the nucleus tractus solitarius of rats: Relationship with noradrenaline and vasopressinPeptides, 6
Eva Ekblad, R. Håkanson, Frank Sundler (1984)
VIP and PHI coexist with an NPY-like peptide in intramural neurones of the small intestineRegulatory Peptides, 10
J. Dietz, M. Field (1973)
Ion transport in rabbit ileal mucosa. IV. Bicarbonate secretion.The American journal of physiology, 225 4
Larsson (1976)
Pancreatic polypeptide - a postulated new hormone: identification of its cellular storage site by light and electron microscopic immunocytochemistryDiabetolog., 12
E. Chang, M. Field, R. Miller (1983)
Enterocyte alpha 2-adrenergic receptors: yohimbine and p-aminoclonidine binding relative to ion transport.The American journal of physiology, 244 1
Bolton (1977)
Ca ionophore-stimulated ion secretion in rabbit ileal mucosa: relation to actions of cyclic 3′,5′-AMP and carbamylcholineJ. Membr. Biol., 35
1 Neuropeptide Y (NPY) is a major gut peptide localized in the intestinal mucosa of several mammalian species. Ileal mucosa from rabbit and guinea‐pig was mounted in Ussing chambers in order to study the effect of NPY on short circuit current. 2 Neuropeptide Y inhibited the short circuit current when applied to the serosal side of the tissue. The maximum change in short circuit current was − 50 ± 6 μA cm−2 in the rabbit ileum and − 49 ± 14 μA cm−2 in the guinea‐pig ileum. The EC50 was 3 × 10−8 M in both species. 3 Pretreatment of rabbit ileum with the α2‐adrenoceptor antagonist, yohimbine (1 × 10−6 M) for 10 min did not reduce the response of the tissue to neuropeptide Y (1 × 10−7 M). 4 When applied serosally to rabbit ileal mucosa, the related peptide YY caused a maximum change in short circuit current of − 60 ± 13 μA cm−2; the EC50 was 2 × 10−9 M. 5 Isotopic flux studies in rabbit ileum showed that 1 × 10−7 M neuropeptide Y enhanced mucosal‐toserosal Na+ and Cl− fluxes and reduced serosal‐to‐mucosal Cl− flux. 6 Replacement of chloride with gluconate on both sides of the tissue significantly reduced the change in short circuit current produced by neuropeptide Y (1 × 10−7 M), as did a similar replacement of bicarbonate. 7 It is concluded that neuropeptide Y and peptide YY are the most potent neurotransmitters or hormones so far described in their ability to attenuate electrogenic transport in the small intestine.
British Journal of Pharmacology – Wiley
Published: Jun 1, 1986
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.