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THE ORGANIZATION OF PROTEINS IN THE HUMAN RED BLOOD CELL MEMBRANE : A Review

THE ORGANIZATION OF PROTEINS IN THE HUMAN RED BLOOD CELL MEMBRANE : A Review OF PROTEINS IN THE HUMAN A Review BLOOD CELL MEMBRANE THEODORE L. S T E C K From the Departments of Biochemistry and Medicine, The University of Chicago, Chicago, lllnois 60637 I. I N T R O D U C T I O N The elucidation of the molecular architecture of cell membranes is a central goal for cell biology, as structure lies at the heart of function. The erythrocyte plasma membrane has long provided a favored testing ground for this inquiry. Human red blood cells are readily available, relatively homogeneous, and relevant to medicine. Their plasma membranes can be easily isolated intact and essentially free of contamination from other cells, organelles, and cytoplasmic contents. This membrane is complex enough to be interesting and, to some degree, representative, yet it is simple enough to be analyzed as a whole. These circumstances make it likely that the human red cell plasma membrane will be the first whose molecular anatomy is known in any degree of satisfying detail. The literature concerning the proteins of erythrocyte membranes and membranes in general has been the subject of repeated review (1 9). This article will focus on the localization and modes of association http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Cell Biology Rockefeller University Press

THE ORGANIZATION OF PROTEINS IN THE HUMAN RED BLOOD CELL MEMBRANE : A Review

Theodore L. Steck
The Journal of Cell Biology , Volume 62 (1): 1 – Jul 1, 1974
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Publisher
Rockefeller University Press
Copyright
Copyright © 1974 by The Rockefeller University Press
ISSN
0021-9525
eISSN
1540-8140
DOI
10.1083/jcb.62.1.1
Publisher site
See Article on Publisher Site

Abstract

OF PROTEINS IN THE HUMAN A Review BLOOD CELL MEMBRANE THEODORE L. S T E C K From the Departments of Biochemistry and Medicine, The University of Chicago, Chicago, lllnois 60637 I. I N T R O D U C T I O N The elucidation of the molecular architecture of cell membranes is a central goal for cell biology, as structure lies at the heart of function. The erythrocyte plasma membrane has long provided a favored testing ground for this inquiry. Human red blood cells are readily available, relatively homogeneous, and relevant to medicine. Their plasma membranes can be easily isolated intact and essentially free of contamination from other cells, organelles, and cytoplasmic contents. This membrane is complex enough to be interesting and, to some degree, representative, yet it is simple enough to be analyzed as a whole. These circumstances make it likely that the human red cell plasma membrane will be the first whose molecular anatomy is known in any degree of satisfying detail. The literature concerning the proteins of erythrocyte membranes and membranes in general has been the subject of repeated review (1 9). This article will focus on the localization and modes of association

Journal

The Journal of Cell Biology – Rockefeller University Press

Published: Jul 1, 1974

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