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In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe

In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe We present an integrated photoacoustic and ultrasonic three-dimensional (3-D) volumetric imaging system based on a two-dimensional (2-D) matrix array ultrasound probe. A wavelength-tunable dye laser pumped by a Q -switched Nd:YAG laser serves as the light source and a modified commercial ultrasound imaging system (iU22, Philips Healthcare) with a 2-D array transducer (X7-2, Philips Healthcare) detects both the pulse-echo ultrasound and photoacoustic signals. A multichannel data acquisition system acquires the RF channel data. The imaging system enables rendering of co-registered 3-D ultrasound and photoacoustic images without mechanical scanning. The resolution along the azimuth, elevation, and axial direction are measured to be 0.69, 0.90 and 0.84 mm for photoacoustic imaging. In vivo 3-D photoacoustic mapping of the sentinel lymph node was demonstrated in a rat model using methylene blue dye. These results highlight the clinical potential of 3-D PA imaging for identification of sentinel lymph nodes for cancer staging in humans. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Biomedical Optics SPIE

In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe

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Publisher
SPIE
Copyright
Copyright © 2012 Society of Photo-Optical Instrumentation Engineers
ISSN
1083-3668
eISSN
1560-2281
DOI
10.1117/1.JBO.17.6.061208
pmid
22734738
Publisher site
See Article on Publisher Site

Abstract

We present an integrated photoacoustic and ultrasonic three-dimensional (3-D) volumetric imaging system based on a two-dimensional (2-D) matrix array ultrasound probe. A wavelength-tunable dye laser pumped by a Q -switched Nd:YAG laser serves as the light source and a modified commercial ultrasound imaging system (iU22, Philips Healthcare) with a 2-D array transducer (X7-2, Philips Healthcare) detects both the pulse-echo ultrasound and photoacoustic signals. A multichannel data acquisition system acquires the RF channel data. The imaging system enables rendering of co-registered 3-D ultrasound and photoacoustic images without mechanical scanning. The resolution along the azimuth, elevation, and axial direction are measured to be 0.69, 0.90 and 0.84 mm for photoacoustic imaging. In vivo 3-D photoacoustic mapping of the sentinel lymph node was demonstrated in a rat model using methylene blue dye. These results highlight the clinical potential of 3-D PA imaging for identification of sentinel lymph nodes for cancer staging in humans.

Journal

Journal of Biomedical OpticsSPIE

Published: Jun 1, 2012

Keywords: photoacoustic imaging; ultrasound imaging; three-dimensional imaging; sentinel lymph node

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