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Br^b, a Platelet Alloantigen Involved in Neonatal Alloimmune Thrombocytopenia

Br^b, a Platelet Alloantigen Involved in Neonatal Alloimmune Thrombocytopenia Serum from a pregnant woman with the May-Hegglin anomaly contained a platelet-specific antibody. The serum reacted in the platelet indirect immunofluorescence test (PIIFT) with 97.6% of random donor platelets and those of the father but not with the mother’s own platelets. This antibody induced a moderate thrombocytopenia in the infant that responded to infusion of intravenous immunoglobulin concentrates. The platelet phenotypes were PLA^1 + . Bak^a+, Br^a+/Br^b- for the mother, PLA^1+, Bak^a+, Br^a-/Br^b+ for the father, and PLA^1+, Br^a+/Br^b+ for the neonate. Analysis of the maternal serum with an immunoassay based on monoclonal antibody immobilization of platelet antigens (MAIPA) and immunoprecipitation techniques demonstrated the absence of antibodies directed against HLA class I antigens and that the antigen recognized was located on the platelet-GpIa/IIa complex. This antigen was present on 113/115 random donor platelets, in 7 of the 7 unrelated May-Hegglin platelets, and only absent in 3/24 Br^a+ individuals, including the mother. No platelet-specific antibody was present in the serum of the 7 unrelated May-Hegglin subjects. The antigen recognized by this platelet-specific antibody thus meets the criteria defining the antithetic allele of Br^a, i.e. the Br^b alloantigen. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Vox Sanguinis Karger

Br^b, a Platelet Alloantigen Involved in Neonatal Alloimmune Thrombocytopenia

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Publisher
Karger
Copyright
© 1991 S. Karger AG, Basel
ISSN
0042-9007
eISSN
1423-0410
DOI
10.1159/000461293
Publisher site
See Article on Publisher Site

Abstract

Serum from a pregnant woman with the May-Hegglin anomaly contained a platelet-specific antibody. The serum reacted in the platelet indirect immunofluorescence test (PIIFT) with 97.6% of random donor platelets and those of the father but not with the mother’s own platelets. This antibody induced a moderate thrombocytopenia in the infant that responded to infusion of intravenous immunoglobulin concentrates. The platelet phenotypes were PLA^1 + . Bak^a+, Br^a+/Br^b- for the mother, PLA^1+, Bak^a+, Br^a-/Br^b+ for the father, and PLA^1+, Br^a+/Br^b+ for the neonate. Analysis of the maternal serum with an immunoassay based on monoclonal antibody immobilization of platelet antigens (MAIPA) and immunoprecipitation techniques demonstrated the absence of antibodies directed against HLA class I antigens and that the antigen recognized was located on the platelet-GpIa/IIa complex. This antigen was present on 113/115 random donor platelets, in 7 of the 7 unrelated May-Hegglin platelets, and only absent in 3/24 Br^a+ individuals, including the mother. No platelet-specific antibody was present in the serum of the 7 unrelated May-Hegglin subjects. The antigen recognized by this platelet-specific antibody thus meets the criteria defining the antithetic allele of Br^a, i.e. the Br^b alloantigen.

Journal

Vox Sanguinis – Karger

Published: Jan 1, 2017

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