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C. Chiueh, C. Sun, I. Kopin, W. Fredericks, S. Rapoport (1978)
Entry of [3H]norepinephrine, [125I]albumin and evans blue from blood into brain following unilateral osmotic opening of the blood-brain barrierBrain Research, 145
D. Deshmukh, W. Bear (1977)
THE DISTRIBUTION AND BIOSYNTHESIS OF THE MYELIN ‐GALACTOLIPIDS IN THE SUBCELLULAR FRACTIONS OF BRAINS OF QUAKING AND NORMAL MICE DURING DEVELOPMENTJournal of Neurochemistry, 28
S. Rapoport (1976)
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Metabolic anatomy of focal motor seizures.Archives of neurology, 33 8
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Bypass of the Blood-Brain Barrier to Proteins Without Brain Tissue Damage
O. Sakurada, C. Kennedy, J. Jehle, J. Brown, G. Carbin, L. Sokoloff (1978)
Measurement of local cerebral blood flow with iodo [14C] antipyrine.The American journal of physiology, 234 1
E. Mackenzie, James Mcculloch, Maureen 'keane, J. Pickard, A. Harper, A. Murray, Harper (1976)
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Effect of alterations in plasma osmolality on renal blood flow autoregulation.The American journal of physiology, 211 6
V. Neuser, F. Hoffmeister (1977)
The influence of psychotropic drugs on the local cerebral glucose-utilisation of the rat.Acta neurologica Scandinavica. Supplementum, 64
M. Spatz, Z. RAP, S. Rapoport, I. Klatzo (1976)
EFFECTS OF HYPERTONIC SOLUTIONS AND OF MERCURIC CHLORIDE ON THE UPTAKE OF [14C]GLUCOSE ANALOGUES BY RABBIT BRAINNeuropathology and Applied Neurobiology, 2
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M. Pollay (1975)
Effect of hypertonic solutions on the blood‐brain barrierNeurology, 25
S. Rapoport, H. Thompson (1973)
Osmotic Opening of the Blood-Brain Barrier in the Monkey without Associated Neurological DeficitsScience, 180
B. Wise, R. Perkins, E. Stevenson, K. Scott (1964)
PENETRATION OF C14-LABELLED MANNITOL FROM SERUM INTO CEREBROSPINAL FLUID AND BRAIN.Experimental neurology, 10
(1977)
Local cerebral glucose utilization during cortical spreading depression in rats
S. Rapoport, K. Matthews, H. Thompson (1976)
Absence of Brain Edema After Reversible Osmotic Opening of the Blood-Brain Barrier
L. Sokoloff, M. Reivich, C. Kennedy, M. Rosiers, C. Patlak, K. Pettigrew, O. Sakurada, M. Shinohara (1977)
THE [14C]DEOXYGLUCOSE METHOD FOR THE MEASUREMENT OF LOCAL CEREBRAL GLUCOSE UTILIZATION: THEORY, PROCEDURE, AND NORMAL VALUES IN THE CONSCIOUS AND ANESTHETIZED ALBINO RAT 1Journal of Neurochemistry, 28
L. Sokoloff (1980)
Local cerebral energy metabolism: its relationship to local functional activity and blood flow.Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften, 36 1-3
B. Wise, N. Chater (1962)
The value of hypertonic mannitol solution in decreasing brain mass and lowering cerebro-spinal-fluid pressure.Journal of neurosurgery, 19
(1974)
Relationship between local cerebral blood flow and glucose utilization in the rat
L. Sokoloff (1977)
RELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEMJournal of Neurochemistry, 29
J. Hardebo, L. Edvinsson, E. Mackenzie, C. Owman (1977)
Regional brain uptake of exogenous noradrenaline, and its effect on local cerebral blood flow after osmotic or mechanical opening of the blood-brain barrier in rats.Acta neurologica Scandinavica. Supplementum, 64
A. Raizner, J. Costin, R. Croke, J. Bishop, T. Inglesby, N. Skinner (1973)
Reflex, systemic, and local hemodynamic alterations with experimental hyperosmolality.The American journal of physiology, 224 6
J. Michenfelder (1977)
Blood–Brain Barrier in Physiology and MedicineAnesthesiology, 46
The effects of osmotic opening of the blood‐brain barrier (BBB) on local cerebral glucose utilization (LCGU) were studied in rats with the carbon 14–deoxyglucose method. The BBB was opened to Evans blue dye by unilateral carotid artery perfusion with hypertonic mannitol solution. (14C)‐Deoxyglucose was injected 15 minutes or two to three hours later. Osmotic opening of the BBB resulted in focal areas of intense LCGU in affected areas of the perfused hemisphere. In the contralateral hemisphere, glucose utilization was diminished, especially in cerebral cortical areas. The effects were reversible. LCGU was normal in both hemispheres when permeability to Evans blue returned to normal two to three hours after carotid perfusion. In 3 to 5 experiments the administration of high doses of intravenous diazepam immediately following carotid artery perfusion with mannitol prevented an increase in LCGU in the perfused hemisphere but did not prevent lowering of LCGU in the contralateral hemisphere. Increased LCGU following osmotic opening of the BBB was not accompanied by a rise in local cerebral blood flow as measured by the iodoantipyrine method. Blood flow was, in fact, significantly decreased.
Annals of Neurology – Wiley
Published: Mar 1, 1979
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