Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Osmotic opening of the blood‐brain barrier and local cerebral glucose utilization

Osmotic opening of the blood‐brain barrier and local cerebral glucose utilization The effects of osmotic opening of the blood‐brain barrier (BBB) on local cerebral glucose utilization (LCGU) were studied in rats with the carbon 14–deoxyglucose method. The BBB was opened to Evans blue dye by unilateral carotid artery perfusion with hypertonic mannitol solution. (14C)‐Deoxyglucose was injected 15 minutes or two to three hours later. Osmotic opening of the BBB resulted in focal areas of intense LCGU in affected areas of the perfused hemisphere. In the contralateral hemisphere, glucose utilization was diminished, especially in cerebral cortical areas. The effects were reversible. LCGU was normal in both hemispheres when permeability to Evans blue returned to normal two to three hours after carotid perfusion. In 3 to 5 experiments the administration of high doses of intravenous diazepam immediately following carotid artery perfusion with mannitol prevented an increase in LCGU in the perfused hemisphere but did not prevent lowering of LCGU in the contralateral hemisphere. Increased LCGU following osmotic opening of the BBB was not accompanied by a rise in local cerebral blood flow as measured by the iodoantipyrine method. Blood flow was, in fact, significantly decreased. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annals of Neurology Wiley

Osmotic opening of the blood‐brain barrier and local cerebral glucose utilization

Loading next page...
 
/lp/wiley/osmotic-opening-of-the-blood-brain-barrier-and-local-cerebral-glucose-40bJgRmuV4

References (24)

Publisher
Wiley
Copyright
Copyright © 1979 American Neurological Association
ISSN
0364-5134
eISSN
1531-8249
DOI
10.1002/ana.410050302
pmid
443753
Publisher site
See Article on Publisher Site

Abstract

The effects of osmotic opening of the blood‐brain barrier (BBB) on local cerebral glucose utilization (LCGU) were studied in rats with the carbon 14–deoxyglucose method. The BBB was opened to Evans blue dye by unilateral carotid artery perfusion with hypertonic mannitol solution. (14C)‐Deoxyglucose was injected 15 minutes or two to three hours later. Osmotic opening of the BBB resulted in focal areas of intense LCGU in affected areas of the perfused hemisphere. In the contralateral hemisphere, glucose utilization was diminished, especially in cerebral cortical areas. The effects were reversible. LCGU was normal in both hemispheres when permeability to Evans blue returned to normal two to three hours after carotid perfusion. In 3 to 5 experiments the administration of high doses of intravenous diazepam immediately following carotid artery perfusion with mannitol prevented an increase in LCGU in the perfused hemisphere but did not prevent lowering of LCGU in the contralateral hemisphere. Increased LCGU following osmotic opening of the BBB was not accompanied by a rise in local cerebral blood flow as measured by the iodoantipyrine method. Blood flow was, in fact, significantly decreased.

Journal

Annals of NeurologyWiley

Published: Mar 1, 1979

There are no references for this article.