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Non‐sentinel lymph node involvement in a patient with an atypical Spitz tumor and a positive sentinel node. Report of a case and review of the literature

Non‐sentinel lymph node involvement in a patient with an atypical Spitz tumor and a positive... We report a 20‐year‐old male patient with an atypical Spitz tumor, located in the dorsal aspect of his left hand, and a positive sentinel axillary lymph node. After lymphadenectomy, 1 of 23 non‐sentinel lymph nodes excised was found to contain small multiple deposits of large spindle atypical melanocytes. Reviewing the pertinent literature, 5 of 29 patients with atypical Spitz tumors and positive sentinel nodes who had undergone lymphadenectomy have shown non‐sentinel node involvement (17.2%), a proportion similar to that reported in melanoma patients. The exact nature of atypical Spitz tumors and the interpretation of cell deposits detected in sentinel nodes are still debated; data regarding the non‐sentinel lymph node involvement in patients with atypical Spitz tumors may contribute to better understand the real biological potential of such tumors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cutaneous Pathology Wiley

Non‐sentinel lymph node involvement in a patient with an atypical Spitz tumor and a positive sentinel node. Report of a case and review of the literature

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References (32)

Publisher
Wiley
Copyright
© 2009 John Wiley & Sons A/S
ISSN
0303-6987
eISSN
1600-0560
DOI
10.1111/j.1600-0560.2008.01080.x
pmid
19476530
Publisher site
See Article on Publisher Site

Abstract

We report a 20‐year‐old male patient with an atypical Spitz tumor, located in the dorsal aspect of his left hand, and a positive sentinel axillary lymph node. After lymphadenectomy, 1 of 23 non‐sentinel lymph nodes excised was found to contain small multiple deposits of large spindle atypical melanocytes. Reviewing the pertinent literature, 5 of 29 patients with atypical Spitz tumors and positive sentinel nodes who had undergone lymphadenectomy have shown non‐sentinel node involvement (17.2%), a proportion similar to that reported in melanoma patients. The exact nature of atypical Spitz tumors and the interpretation of cell deposits detected in sentinel nodes are still debated; data regarding the non‐sentinel lymph node involvement in patients with atypical Spitz tumors may contribute to better understand the real biological potential of such tumors.

Journal

Journal of Cutaneous PathologyWiley

Published: May 1, 2009

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