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Protection from diabetes-induced atherosclerosis and renal disease by d -carnosine-octylester: effects of early vs late inhibition of advanced glycation end-products in Apoe -null mice

Protection from diabetes-induced atherosclerosis and renal disease by d -carnosine-octylester:... These data show that DCO protects mice from diabetes-induced vascular and renal disease and that protection against atherosclerosis is more effectively achieved by early treatment than by late treatment, thus suggesting that early inhibition of AGE formation attenuates progression of macroangiopathy and favours development of more stable lesions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Diabetologia Springer Journals

Protection from diabetes-induced atherosclerosis and renal disease by d -carnosine-octylester: effects of early vs late inhibition of advanced glycation end-products in Apoe -null mice

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References (38)

Publisher
Springer Journals
Copyright
Copyright © 2015 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Internal Medicine; Metabolic Diseases; Human Physiology
ISSN
0012-186X
eISSN
1432-0428
DOI
10.1007/s00125-014-3467-6
pmid
25471794
Publisher site
See Article on Publisher Site

Abstract

These data show that DCO protects mice from diabetes-induced vascular and renal disease and that protection against atherosclerosis is more effectively achieved by early treatment than by late treatment, thus suggesting that early inhibition of AGE formation attenuates progression of macroangiopathy and favours development of more stable lesions.

Journal

DiabetologiaSpringer Journals

Published: Apr 1, 2015

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