Access the full text.
Sign up today, get DeepDyve free for 14 days.
Shufeng Zhou, L. Lim, B. Chowbay (2004)
Herbal Modulation of P‐GlycoproteinDrug Metabolism Reviews, 36
E. Ernst (2000)
Herb-drug interactions: potentially important but woefully under-researchedEuropean Journal of Clinical Pharmacology, 56
O. Lowry, N. Rosebrough, A. Farr, R. Randall (1951)
Protein measurement with the Folin phenol reagent.The Journal of biological chemistry, 193 1
M. Janahmadi, Farshad Niazi, S. Danyali, M. Kamalinejad (2006)
Effects of the fruit essential oil of Cuminum cyminum Linn. (Apiaceae) on pentylenetetrazol-induced epileptiform activity in F1 neurones of Helix aspersa.Journal of ethnopharmacology, 104 1-2
R. Sandström, H. Lennernäs (1999)
Repeated oral rifampicin decreases the jejunal permeability of R/S-verapamil in rats.Drug metabolism and disposition: the biological fate of chemicals, 27 8
K. Srinivasan (2005)
Plant foods in the management of diabetes mellitus: Spices as beneficial antidiabetic food adjunctsInternational Journal of Food Sciences and Nutrition, 56
K. Sambaiah, K. Srinivasan (1991)
Effect of cumin, cinnamon, ginger, mustard and tamarind in induced hypercholesterolemic rats.Die Nahrung, 35 1
S. Satyanarayana, K. Sushruta, G. Sarma, N. Srinivas, G. Raju (2004)
Antioxidant Activity of the Aqueous Extracts of Spicy Food Additives—Evaluation and Comparison with Ascorbic Acid in In Vitro SystemsJournal Of Herbal Pharmacotherapy, 4
El‐Negoumy El‐Negoumy, Mansour Mansour (1989)
Flavone glycosides of Cuminum cyminum seedsFasc, 40
E. Calabrese (2006)
What is the purpose of a risk assessment?Human and Experimental Toxicology, 25
R. Notari (1980)
Biopharmaceutics and clinical pharmacokinetics: An introduction
(2001)
Drugs used in the chemotherapy of tuberculosis, Mycobacterium avium complex disease, and leprosy
R. Venkataramanan, B. Komoroski, S. Strom (2006)
In vitro and in vivo assessment of herb drug interactions.Life sciences, 78 18
J. Brown, J. Collett, D. Attwood, R. Ley, E. Sims (2002)
Influence of monocaprin on the permeability of a diacidic drug BTA-243 across Caco-2 cell monolayers and everted gut sacs.International journal of pharmaceutics, 245 1-2
Xiaodong Wang, A. Wolkoff, M. Morris (2005)
FLAVONOIDS AS A NOVEL CLASS OF HUMAN ORGANIC ANION-TRANSPORTING POLYPEPTIDE OATP1B1 (OATP-C) MODULATORSDrug Metabolism and Disposition, 33
M. Magnarin, M. Morelli, A. Rosati, F. Bartoli, L. Candussio, T. Giraldi, G. Decorti (2004)
Induction of proteins involved in multidrug resistance (P-glycoprotein, MRP1, MRP2, LRP) and of CYP 3A4 by rifampicin in LLC-PK1 cells.European journal of pharmacology, 483 1
T. Malini, G. Vanithakumari (1987)
Estrogenic activity of Cuminum cyminum in rats.Indian journal of experimental biology, 25 7
B. Aungst (2000)
Intestinal permeation enhancers.Journal of pharmaceutical sciences, 89 4
C. Shishoo, S.A Shah, I. Rathod, S. Savale, M.J Vora (2001)
Impaired bioavailability of rifampicin in presence of isoniazid from fixed dose combination (FDC) formulation.International journal of pharmaceutics, 228 1-2
S. Khafagy, T. Sarg, N. Salam, O. Gabr (1978)
Isolation of two flavone glycosides from the fruits of Cuminum cyminum L. grown in Egypt.Die Pharmazie, 33 5
R. Román-Ramos, J. Flores-Saenz, F. Alarcón-Aguilar (1995)
Anti-hyperglycemic effect of some edible plants.Journal of ethnopharmacology, 48 1
T. Ishikawa, Tomomi Takayanagi, J. Kitajima (2002)
Water-soluble constituents of cumin: monoterpenoid glucosides.Chemical & pharmaceutical bulletin, 50 11
C. Cummins, W. Jacobsen, L. Benet (2002)
Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.The Journal of pharmacology and experimental therapeutics, 300 3
A. Nostro, L. Cellini, S. Bartolomeo, E. Campli, R. Grande, M. Cannatelli, L. Marzio, V. Alonzo (2005)
Antibacterial effect of plant extracts against Helicobacter pyloriPhytotherapy Research, 19
P. Fu, Q. Xia, G. Lin, M. Chou (2004)
Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and MechanismsDrug Metabolism Reviews, 36
P. Tirumalasetty, J. Eley (2006)
Permeability enhancing effects of the alkylglycoside, octylglucoside, on insulin permeation across epithelial membrane in vitro.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 9 1
S. Deferme, P. Augustijns (2003)
The effect of food components on the absorption of P‐gp substrates: a reviewJournal of Pharmacy and Pharmacology, 55
K. Aruna, R. Rukkumani, P. Varma, V. Menon (2005)
Therapeutic role of Cuminum cyminum on ethanol and thermally oxidized sunflower oil induced toxicityPhytotherapy Research, 19
Saranjit Singh, T. Mariappan, Ravi Shankar, N. Sarda, Baljinder Singh (2001)
A critical review of the probable reasons for the poor variable bioavailability of rifampicin from anti-tubercular fixed-dose combination (FDC) products, and the likely solutions to the problem.International journal of pharmaceutics, 228 1-2
Aungst Aungst (2005)
Intestinal permeation enhancersJ Pharm Pharmacol, 89
SA Tasduq, Singh, NK Satti, DK Gupta, KA Suri, R. Johri (2006)
Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combinationHuman and Experimental Toxicology, 25
Tomomi Takayanagi, T. Ishikawa, J. Kitajima (2003)
Sesquiterpene lactone glucosides and alkyl glycosides from the fruit of cumin.Phytochemistry, 63 4
A. Haghparast, J. Shams, A. Khatibi, A. Alizadeh, M. Kamalinejad (2008)
Effects of the fruit essential oil of Cuminum cyminum Linn. (Apiaceae) on acquisition and expression of morphine tolerance and dependence in miceNeuroscience Letters, 440
T. Mariappan, Saranjit Singh (2004)
Evidence of efflux-mediated and saturable absorption of rifampicin in rat intestine using the ligated loop and everted gut sac techniques.Molecular pharmaceutics, 1 5
N. Nalini, K. Sabitha, P. Viswanathan, V. Menon (1998)
Influence of spices on the bacterial (enzyme) activity in experimental colon cancer.Journal of ethnopharmacology, 62 1
V. Wacher, Chi‐Yuan Wu, L. Benet (1995)
Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapyMolecular Carcinogenesis, 13
N. Iacobellis, P. Cantore, F. Capasso, F. Senatore (2005)
Antibacterial activity of Cuminum cyminum L. and Carum carvi L. essential oils.Journal of agricultural and food chemistry, 53 1
M. Boskabady, S. Kiani, H. Azizi (2005)
Relaxant effect of Cuminum cyminum on guinea pig tracheal chains and its possible mechanism(s)Indian Journal of Pharmacology, 37
J. Kitajima, T. Ishikawa, Eiko Fujimatu, Kyoko Kondho, Tomomi Takayanagi (2003)
Glycosides of 2-C-methyl-D-erythritol from the fruits of anise, coriander and cumin.Phytochemistry, 62 1
The bioavailability of rifampicin (RIF) in a fixed dose combination (FDC) used for the treatment of tuberculosis remains an area of clinical concern and several pharmaceutical alternatives are being explored to overcome this problem. The present study presents a pharmacological approach in which the bioavailability of a drug may be modulated by utilizing the herb–drug synergism. The pharmacokinetic interaction of some herbal products and a pure molecule isolated from Cuminum cyminum with RIF is shown in this paper. An aqueous extract derived from cumin seeds produced a significant enhancement of RIF levels in rat plasma. This activity was found to be due to a flavonoid glycoside, 3′,5–dihydroxyflavone 7‐O‐β‐d‐galacturonide4′‐O‐β‐d‐glucopyranoside (CC‐I). CC‐I enhanced the Cmax by 35% and AUC by 53% of RIF. The altered bioavailability profile of RIF could be attributed to a permeation enhancing effect of this glycoside. Copyright © 2006 John Wiley & Sons, Ltd.
Phytotherapy Research – Wiley
Published: Feb 1, 2007
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.