Access the full text.
Sign up today, get DeepDyve free for 14 days.
Masaiwa Motoyama, S. Yamazaki, Akiko Eto-Kimura, K. Takeshige, T. Muta (2005)
Positive and Negative Regulation of Nuclear Factor-κB-mediated Transcription by IκB-ζ, an Inducible Nuclear Protein*Journal of Biological Chemistry, 280
G. Fontaine, J. Belknap, D. Allen, J. Moore, D. Kroll (2001)
Expression of interleukin-1beta in the digital laminae of horses in the prodromal stage of experimentally induced laminitis.American journal of veterinary research, 62 5
M. Sewnath, D. Olszyna, R. Birjmohun, F. Kate, D. Gouma, T. Poll (2001)
IL-10-Deficient Mice Demonstrate Multiple Organ Failure and Increased Mortality During Escherichia coli Peritonitis Despite an Accelerated Bacterial Clearance1The Journal of Immunology, 166
Philip Johnson, S. Tyagi, L. Katwa, V. Ganjam, L. Moore, J. Kreeger, N. Messer (1998)
Activation of extracellular matrix metalloproteinases in equine laminitisVeterinary Record, 142
J. Buras, B. Holzmann, M. Sitkovsky (2005)
Model organisms: Animal Models of sepsis: setting the stageNature Reviews Drug Discovery, 4
R. Waguespack, A. Cochran, J. Belknap (2004)
Expression of the cyclooxygenase isoforms in the prodromal stage of black walnut-induced laminitis in horses.American journal of veterinary research, 65 12
L. Armstrong, A. Millar (1997)
Relative production of tumour necrosis factor alpha and interleukin 10 in adult respiratory distress syndrome.Thorax, 52
M. Oldruitenborgh-Oosterbaan (1999)
Laminitis in the horse: a review.Veterinary Quarterly, 21
C. Pollitt (1996)
Basement membrane pathology: a feature of acute equine laminitis.Equine veterinary journal, 28 1
Baxter (1994)
Acute laminitisVet. Clin. N. Am.: Equine Pract., 10
Baxter (1996)
The pathophysiology of acute laminitisVet. Med., 91
D. Hurley, R. Parks, A. Reber, D. Donovan, T. Okinaga, M. Vandenplas, J. Peroni, J. Moore (2006)
Dynamic changes in circulating leukocytes during the induction of equine laminitis with black walnut extract.Veterinary immunology and immunopathology, 110 3-4
H. Garner, J. Coffman, A. Hahn, D. Hutcheson, M. Tumbleson (1975)
Equine laminitis of alimentary origin: an experimental model.American journal of veterinary research, 36 4 Pt.1
Annane (2005)
Septic shockLancet, 365
Yamamoto Yamamoto, Yamazaki Yamazaki, Uematsu Uematsu, Sato Sato, Hemmi Hemmi, Hoshino Hoshino, Kaisho Kaisho, Kuwata Kuwata, Takeuchi Takeuchi, Takeshige Takeshige, Saitoh Saitoh, Yamaoka Yamaoka, Yamamoto Yamamoto, Yamamoto Yamamoto, Muta Muta, Takeda Takeda, Akira Akira (2004)
Regulation of Toll/IL‐1‐receptor‐mediated gene expression by the inducible nuclear protein IkappaBzetaNature, 430
D. Hood (1999)
The pathophysiology of developmental and acute laminitis.The Veterinary clinics of North America. Equine practice, 15 2
P. Hynes-Gay, Patti Lalla, M. Leo, Audrey Merrill-Bell, M. Nicholson, E. Villaruel (2002)
Understanding sepsis: from SIRS to septic shock.Dynamics, 13 1
M. Keel, O. Trentz (2005)
Pathophysiology of polytrauma.Injury, 36 6
J. Moore, D. Allen, E. Clark (1989)
Pathophysiology of acute laminitis.The Veterinary clinics of North America. Equine practice, 5 1
D. Gor, N. Rose, N. Greenspan (2003)
TH1-TH2: a Procrustean paradigmNature Immunology, 4
M. Hirschfeld, J. Weis, V. Toshchakov, C. Salkowski, M. Cody, D. Ward, N. Qureshi, S. Michalek, S. Vogel (2001)
Signaling by Toll-Like Receptor 2 and 4 Agonists Results in Differential Gene Expression in Murine MacrophagesInfection and Immunity, 69
K. French, C. Pollitt (2010)
Equine laminitis: cleavage of laminin 5 associated with basement membrane dysadhesion.Equine veterinary journal, 36 3
L. Katwa, P. Johnson, V. Ganjam, J. Kreeger, N. Messer (1999)
Expression of endothelin in equine laminitis.Equine veterinary journal, 31 3
B. Mungall, C. Pollitt (1999)
Zymographic analysis of equine laminitisHistochemistry and Cell Biology, 112
R. Sprouse, Garner He, Green Em (1987)
Plasma endotoxin levels in horses subjected to carbohydrate induced laminitis.Equine veterinary journal, 19 1
S. Frantz, J. Bauersachs, R. Kelly (2005)
Innate immunity and the heart.Current pharmaceutical design, 11 10
N. Ferguson, H. Galley, N. Webster (1999)
T helper cell subset ratios in patients with severe sepsisIntensive Care Medicine, 25
S. O’Sullivan, J. Lederer, A. Horgan, D. Chin, J. Mannick, Rodrick Ml, J. Meakins, C. Baker, B. Pruitt, S. Galandiuk (1995)
Major injury leads to predominance of the T helper-2 lymphocyte phenotype and diminished interleukin-12 production associated with decreased resistance to infection.Annals of Surgery, 222
M. Bhatia, S. Moochhala (2004)
Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndromeThe Journal of Pathology, 202
D. Remick, G. Bolgos, S. Copeland, J. Siddiqui (2005)
Role of Interleukin-6 in Mortality from and Physiologic Response to SepsisInfection and Immunity, 73
S. Eaton, D. Allen, S. Eades, D. Schneider (1995)
Digital Starling forces and hemodynamics during early laminitis induced by an aqueous extract of black walnut (Juglans nigra) in horses.American journal of veterinary research, 56 10
Pollitt (1999)
Equine laminitis: a revised pathophysiologyProc. Am. Ass. equine Practnrs., 45
L. Thijs, C. Hack (1995)
Time course of cytokine levels in sepsisIntensive Care Medicine, 21
Masahiro Yamamoto, S. Yamazaki, S. Uematsu, Shintaro Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Kuwata, O. Takeuchi, K. Takeshige, T. Saitoh, S. Yamaoka, N. Yamamoto, Shunsuke Yamamoto, T. Muta, K. Takeda, S. Akira (2004)
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζNature, 430
P. Kidd (2003)
Th1/Th2 balance: the hypothesis, its limitations, and implications for health and disease.Alternative medicine review : a journal of clinical therapeutic, 8 3
Pollitt Pollitt (2004)
Equine laminitisClin. Techn. Equine Pract., 3
N. Garton, M. Gilleron, T. Brando, Han Dan, S. Giguère, G. Puzo, J. Prescott, I. Sutcliffe (2002)
A novel lipoarabinomannan from the equine pathogen Rhodococcus equi. Structure and effect on macrophage cytokine production.The Journal of biological chemistry, 277 35
P. Boontham, P. Chandran, Brianna Rowlands, O. Eremin (2003)
Surgical sepsis: dysregulation of immune function and therapeutic implications.The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland, 1 4
S. Black, D. Lunn, C. Yin, Misako Hwang, S. Lenz, J. Belknap (2006)
Leukocyte emigration in the early stages of laminitis.Veterinary immunology and immunopathology, 109 1-2
F. Yeh, H.D Shen, R. Fang (2002)
Deficient transforming growth factor beta and interleukin-10 responses contribute to the septic death of burned patients.Burns : journal of the International Society for Burn Injuries, 28 7
Jonathan Cohen (2002)
The immunopathogenesis of sepsisNature, 420
J. Vandesompele, K. Preter, F. Pattyn, B. Poppe, N. Roy, A. Paepe, F. Speleman (2002)
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genesGenome Biology, 3
R. Waguespack, R. Kemppainen, A. Cochran, H. Lin, J. Belknap (2010)
Increased expression of MAIL, a cytokine-associated nuclear protein, in the prodromal stage of black walnut-induced laminitis.Equine veterinary journal, 36 3
Summary Reasons for performing study: Recent research has indicated that inflammation plays a role in the early stages of laminitis and that, similar to organ failure in human sepsis, early inflammatory mechanisms may lead to downstream events resulting in lamellar failure. Characterisation of the type of immune response (i.e. innate vs. adaptive) is essential in order to develop therapeutic strategies to counteract these deleterious events. Objectives: To quantitate gene expression of pro‐inflammatory cytokines known to be important in the innate and adaptive immune response during the early stages of laminitis, using both the black walnut extract (BWE) and oligofructose (OF) models of laminitis. Methods: Real‐time qPCR was used to assess lamellar mRNA expression of interleukins‐1β, 2, 4, 6, 8, 10, 12 and 18, and tumour necrosis factor alpha and interferon gamma at the developmental stage and at the onset of lameness. Results: Significantly increased lamellar mRNA expression of cytokines important in the innate immune response were present at the developmental stage of the BWE model, and at the onset of acute lameness in both the BWE model and OF model. Of the cytokines characteristic of the Th1 and Th2 arms of the adaptive immune response, a mixed response was noted at the onset of acute lameness in the BWE model, whereas the response was skewed towards a Th1 response at the onset of lameness in the OF model. Conclusions: Lamellar inflammation is characterised by strong innate immune response in the developmental stages of laminitis; and a mixture of innate and adaptive immune responses at the onset of lameness. Potential relevance: These results indicate that anti‐inflammatory treatment of early stage laminitis (and the horse at risk of laminitis) should include not only therapeutic drugs that address prostanoid activity, but should also address the marked increases in lamellar cytokine expression.
Equine Veterinary Journal – Wiley
Published: Jan 1, 2007
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.