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Cell proliferation kinetics in five human solid tumors

Cell proliferation kinetics in five human solid tumors The in‐vivo study of the cell cycle in human tumors with the labeled mitosis curve is possible if the choice of patient conforms to certain criteria. In four of our cases good data were obtained, T8 varied between 7 and 19 hours and Tc between 1 day and 4 days. In two of the patients the shape of the curve suggests large fluctuations of the durations of the various phases of the cell cycle. For the third patient the peak of the labeled mitosis curve never exceeds 50%; this large spread of the duration of the phases of the cell cycle within the tumor cell population may be due to previous treatment of his tumor. There is a large discrepancy between the clinical doubling time and the potential doubling time computed on the basis of Tc and GF and assuming no cell loss. This discrepancy seems to indicate that the extent of cell loss is a major parameter of the growth rate of human tumors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cancer Wiley

Cell proliferation kinetics in five human solid tumors

Frindel Malaise, E.; Tubiana, M.
Cancer , Volume 22 (3) – Sep 1, 1968
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References (21)

Publisher
Wiley
Copyright
Copyright © 1968 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0008-543X
eISSN
1097-0142
DOI
10.1002/1097-0142(196809)22:3<611::AID-CNCR2820220317>3.0.CO;2-I
Publisher site
See Article on Publisher Site

Abstract

The in‐vivo study of the cell cycle in human tumors with the labeled mitosis curve is possible if the choice of patient conforms to certain criteria. In four of our cases good data were obtained, T8 varied between 7 and 19 hours and Tc between 1 day and 4 days. In two of the patients the shape of the curve suggests large fluctuations of the durations of the various phases of the cell cycle. For the third patient the peak of the labeled mitosis curve never exceeds 50%; this large spread of the duration of the phases of the cell cycle within the tumor cell population may be due to previous treatment of his tumor. There is a large discrepancy between the clinical doubling time and the potential doubling time computed on the basis of Tc and GF and assuming no cell loss. This discrepancy seems to indicate that the extent of cell loss is a major parameter of the growth rate of human tumors.

Journal

Cancer – Wiley

Published: Sep 1, 1968

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