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Betty Gallagher, A. Hainski, Sally Moody (1991)
Autonomous differentiation of dorsal axial structures from an animal cap cleavage stage blastomere in Xenopus.Development, 112 4
T. Yamada (1950)
Dorsalization of the ventral marginal zone of the triturus gastrula. I. Ammonia-treatment of the medioventral marginal zone.The Biological bulletin, 98 2
A. MacNicol, Anthony Muslin, L. Williams (1993)
Raf-1 kinase is essential for early Xenopus development and mediates the induction of mesoderm by FGFCell, 73
J. Gurdon, S. Fairman, T. Mohun, S. Brennan (1985)
Activation of muscle-specific actin genes in xenopus development by an induction between animal and vegetal cells of a blastulaCell, 41
J. Shih, Ray Keller (1992)
The epithelium of the dorsal marginal zone of Xenopus has organizer properties.Development, 116 4
H. Grunz, L. Tacke (1989)
Neural differentiation of Xenopus laevis ectoderm takes place after disaggregation and delayed reaggregation without inducer.Cell differentiation and development : the official journal of the International Society of Developmental Biologists, 28 3
Herbert Steinbeisser, E. Robertis, Min Ku, Daniel Kessler, Douglas Melton (1993)
Xenopus axis formation: induction of goosecoid by injected Xwnt-8 and activin mRNAs.Development, 118 2
Jian Zhang, M. King (1996)
Xenopus VegT RNA is localized to the vegetal cortex during oogenesis and encodes a novel T-box transcription factor involved in mesodermal patterning.Development, 122 12
J. Thompson, J. Slack (1992)
Over-expression of fibroblast growth factors in Xenopus embryosMechanisms of Development, 38
P. Mathers, A. Miller, T. Doniach, M. Dirksen, M. Jamrich (1995)
Initiation of anterior head-specific gene expression in uncommitted ectoderm of Xenopus laevis by ammonium chloride.Developmental biology, 171 2
J. Yang-Snyder, Jeffrey Miller, Jeffrey Brown, Cheng-Jung Lai, R. Moon (1996)
A frizzled homolog functions in a vertebrate Wnt signaling pathwayCurrent Biology, 6
J. Massagué (1996)
TGFβ Signaling: Receptors, Transducers, and Mad ProteinsCell, 85
DJ Olson, JL Christian, RT Moon (1991)
Effect of wnt-1 and related proteins on gap junctional communication in Xenopus embryosScience, 252
Anne Knecht, P. Good, I. Dawid, R. Harland (1995)
Dorsal-ventral patterning and differentiation of noggin-induced neural tissue in the absence of mesoderm.Development, 121 6
J. Shih, Scott Fraser (1996)
Characterizing the zebrafish organizer: microsurgical analysis at the early-shield stage.Development, 122 4
A. Aono, M. Hazama, K. Notoya, S. Taketomi, H. Yamasaki, R. Tsukuda, Shigekazu Sasaki, Y. Fujisawa (1995)
Potent ectopic bone-inducing activity of bone morphogenetic protein-4/7 heterodimer.Biochemical and biophysical research communications, 210 3
G. Henry, Iman Brivanlou, D. Kessler, A. Hemmati‐Brivanlou, D. Melton (1996)
TGF-beta signals and a pattern in Xenopus laevis endodermal development.Development, 122 3
Sergei Sokol, Douglas Melton (1991)
Pre-existent pattern in Xenopus animal pole cells revealed by induction with activinNature, 351
Lyle Zimmerman, José Jesús-Escobar, R. Harland (1996)
The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4Cell, 86
Leslie Dale, J. Slack (1987)
Fate map for the 32-cell stage of Xenopus laevis.Development, 99 4
C. Jones, K. Lyons, Peter An, C. Wright, Brigid Hogan (1992)
DVR-4 (bone morphogenetic protein-4) as a posterior-ventralizing factor in Xenopus mesoderm induction.Development, 115 2
J. Smith, J. Slack (1983)
Dorsalization and neural induction: properties of the organizer in Xenopus laevis.Journal of embryology and experimental morphology, 78
J. Gurdon, P. Harger, A. Mitchell, P. Lemaire (1994)
Activin signalling and response to a morphogen gradientNature, 371
M. Molenaar, M. Wetering, M. Oosterwegel, J. Peterson-Maduro, S. Godsave, V. Kořínek, J. Roose, O. Destrée, H. Clevers (1996)
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus EmbryosCell, 86
K. Kroll, E. Amaya (1996)
Transgenic Xenopus embryos from sperm nuclear transplantations reveal FGF signaling requirements during gastrulation.Development, 122 10
C. Dohrmann, A. Hemmati‐Brivanlou, G. Thomsen, A. Fields, T. Woolf, D. Melton (1993)
Expression of activin mRNA during early development in Xenopus laevis.Developmental biology, 157 2
M. Vodicka, J. Gerhart (1995)
Blastomere derivation and domains of gene expression in the Spemann Organizer of Xenopus laevis.Development, 121 11
H. Uchiyama, T. Nakamura, S. Komazaki, K. Takio, M. Asashima, H. Sugino (1994)
Localization of activin and follistatin proteins in the Xenopus oocyte.Biochemical and biophysical research communications, 202 1
S. Scharf, J. Gerhart (1983)
Axis determination in eggs of Xenopus laevis: a critical period before first cleavage, identified by the common effects of cold, pressure and ultraviolet irradiation.Developmental biology, 99 1
A. Fainsod, H. Steinbeisser, E. Robertis (1994)
On the function of BMP‐4 in patterning the marginal zone of the Xenopus embryo.The EMBO Journal, 13
G. Carnac, L. Kodjabachian, J. Gurdon, P. Lemaire (1996)
The homeobox gene Siamois is a target of the Wnt dorsalisation pathway and triggers organiser activity in the absence of mesoderm.Development, 122 10
W. Smith, R. Mckendry, S. Ribisi, R. Harland (1995)
A nodal-related gene defines a physical and functional domain within the Spemann organizerCell, 82
Alla Karnovsky, M. Klymkowsky (1995)
Anterior axis duplication in Xenopus induced by the over-expression of the cadherin-binding protein plakoglobin.Proceedings of the National Academy of Sciences of the United States of America, 92 10
P. Lemaire, P. Lemaire, N. Garrett, N. Garrett, J. Gurdon, J. Gurdon (1995)
Expression cloning of Siamois, a xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axisCell, 81
P. Harger, J. Gurdon (1996)
Mesoderm induction and morphogen gradientsSeminars in Cell & Developmental Biology, 7
N. Kinoshita, J. Minshull, M. Kirschner (1995)
The identification of two novel ligands of the fgf receptor by a yeast screening method and their activity in xenopus developmentCell, 83
E. Houliston, R. Elinson (1991)
Patterns of microtubule polymerization relating to cortical rotation in Xenopus laevis eggs.Development, 112 1
C. Jones, N. Armes, James Smith (1996)
Signalling by TGF-β family members: short-range effects of Xnr-2 and BMP-4 contrast with the long-range effects of activinCurrent Biology, 6
C. London, R. Akers, C. Phillips (1988)
Expression of Epi 1, an epidermis-specific marker in Xenopus laevis embryos, is specified prior to gastrulation.Developmental biology, 129 2
N. Papalopulu, C. Kintner (1993)
Xenopus Distal-less related homeobox genes are expressed in the developing forebrain and are induced by planar signals.Development, 117 3
R. Keller (1975)
Vital Dye Mapping of the Gastrula and Neurula of Xenopus LaevisDevelopmental Biology, 42
M. Umbhauer, C. Marshall, C. Mason, R. Old, James Smith (1995)
Mesoderm induction in Xenopus caused by activation of MAP kinaseNature, 376
S. Sokol, D. Melton (1992)
Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus.Developmental biology, 154 2
H. Sive, Ken-ichi Hattori, H. Weintraub (1989)
Progressive determination during formation of the anteroposterior axis in Xenopus laevisCell, 58
Y. Sasai, B. Lu, H. Steinbeisser, D. Geissert, L. Gont, E. Robertis (1994)
Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genesCell, 79
Shouwen Wang, M. Krinks, Keming Lin, F. Luyten, M. Moos (1997)
Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8Cell, 88
Carin Hansen, C. Marion, Kirsten Steele, Sean George, William Smith (1997)
Direct neural induction and selective inhibition of mesoderm and epidermis inducers by Xnr3.Development, 124 2
Chenbei Chang, Paul Wilson, L. Mathews, A. Hemmati‐Brivanlou (1997)
A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis.Development, 124 4
M. Taira, J. Saint-Jeannet, I. Dawid (1997)
Role of the Xlim-1 and Xbra genes in anteroposterior patterning of neural tissue by the head and trunk organizer.Proceedings of the National Academy of Sciences of the United States of America, 94 3
Paul Wilson, A. Hemmati‐Brivanlou (1995)
Induction of epidermis and inhibition of neural fate by Bmp-4Nature, 376
D. Darnell, G. Schoenwolf (1995)
Dorsoventral patterning of the avian mesencephalon/metencephalon: role of the notochord and floor plate in suppressing Engrailed-2.Journal of neurobiology, 26 1
S. Schulte‐Merker, J. Smith, L. Dale (1994)
Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction?The EMBO Journal, 13
Bruce Bejcek, Dean Li, Thomas Deuel (1989)
Transformation by v-sis occurs by an internal autoactivation mechanism.Science, 245 4925
J. Gurdon (1989)
The heritage of experimental embryology: Hans Spemann and the organizer by Viktor Hamburger, Oxford University Press, 1988. £22.50/$29.95 (196 pages) ISBN 0 19505 110 6Trends in Neurosciences, 12
B. Rowning, J. Wells, Mike Wu, J. Gerhart, R. Moon, C. Larabell (1997)
Microtubule-mediated transport of organelles and localization of beta-catenin to the future dorsal side of Xenopus eggs.Proceedings of the National Academy of Sciences of the United States of America, 94 4
C. Jones, M. Kuehn, B. Hogan, James Smith, C. Wright (1995)
Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation.Development, 121 11
G. Lagna, A. Hata, A. Hemmati‐Brivanlou, J. Massagué (1996)
Partnership between DPC4 and SMAD proteins in TGF-β signalling pathwaysNature, 383
C. Wylie, M. Kofron, C. Payne, Robert Anderson, M. Hosobuchi, E. Joseph, J. Heasman (1996)
Maternal beta-catenin establishes a 'dorsal signal' in early Xenopus embryos.Development, 122 10
A. Hemmati‐Brivanlou, J. Torre, Christine Holt, M. Richard, Harland (1991)
Cephalic expression and molecular characterization of Xenopus En-2.Development, 111 3
R. Stewart, John Gerhart (1990)
The anterior extent of dorsal development of the Xenopus embryonic axis depends on the quantity of organizer in the late blastula.Development, 109 2
H. Kageura (1997)
Activation of dorsal development by contact between the cortical dorsal determinant and the equatorial core cytoplasm in eggs of Xenopus laevis.Development, 124 8
G. Thomsen (1996)
Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor.Development, 122 8
A. Hemmati‐Brivanlou, R. Stewart, R. Harland (1990)
Region-specific neural induction of an engrailed protein by anterior notochord in Xenopus.Science, 250 4982
J. Gerhart, T. Doniach, R. Stewart (1991)
Organizing the Xenopus Organizer
S. Holley, J. Neul, L. Attisano, J. Wrana, Y. Sasai, M. O’Connor, E. Robertis, E. Ferguson (1996)
The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its ReceptorCell, 86
T. Bouwmeester, Sung-Hyun Kim, Y. Sasai, B. Lu, E. Robertis (1996)
Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizerNature, 382
J. Gurdon, A. Mitchell, D. Mahony (1995)
Direct and continuous assessment by cells of their position in a morphogen gradientNature, 376
R. Keller, M. Danilchik (1988)
Regional expression, pattern and timing of convergence and extension during gastrulation of Xenopus laevis.Development, 103 1
Kolja Eppert, S. Scherer, H. Ozçelik, R. Pirone, P. Hoodless, Hyeja Kim, L. Tsui, B. Bapat, S. Gallinger, I. Andrulis, G. Thomsen, J. Wrana, L. Attisano (1996)
MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal CarcinomaCell, 86
J. Graff, A. Bansal, D. Melton (1996)
Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ SuperfamilyCell, 85
P. Lemaire, J. Gurdon (1994)
A role for cytoplasmic determinants in mesoderm patterning: cell-autonomous activation of the goosecoid and Xwnt-8 genes along the dorsoventral axis of early Xenopus embryos.Development, 120 5
James Smith, B. Price, K. Nimmen, Danny Huylebroeck (1990)
Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin ANature, 345
M. Pownall, A. Tucker, J. Slack, H. Isaacs (1996)
eFGF, Xcad3 and Hox genes form a molecular pathway that establishes the anteroposterior axis in Xenopus.Development, 122 12
J. Shih, Ray Keller (1992)
Patterns of cell motility in the organizer and dorsal mesoderm of Xenopus laevis.Development, 116 4
L. Dale, G. Howes, B. Price, James Smith (1992)
Bone morphogenetic protein 4: a ventralizing factor in early Xenopus development.Development, 115 2
M. Yuge, Y. Kobayakawa, M. Fujisue, K. Yamana (1990)
A cytoplasmic determinant for dorsal axis formation in an early embryo of Xenopus laevis.Development, 110 4
M. Selleck, M. Bronner‐Fraser (1995)
Origins of the avian neural crest: the role of neural plate-epidermal interactions.Development, 121 2
Masanori Taira, Milan Jamrich, Peter Good, Igor Dawid (1992)
The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos.Genes & development, 6 3
P. Klein, D. Melton (1996)
A molecular mechanism for the effect of lithium on development.Proceedings of the National Academy of Sciences of the United States of America, 93 16
Kathleen Guger, B. Gumbiner (1995)
beta-Catenin has Wnt-like activity and mimics the Nieuwkoop signaling center in Xenopus dorsal-ventral patterning.Developmental biology, 172 1
K. Lustig, K. Kroll, E. Sun, M. Kirschner (1996)
Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation.Development, 122 12
T. Lamb, Anne Knecht, W. Smith, S. Stachel, A. Economides, N. Stahl, George Yancopolous, R. Harland (1993)
Neural induction by the secreted polypeptide noggin.Science, 262 5134
C. Grabowski (1956)
The effects of the excision of Hensen's node on the early development of the chick embryoJournal of Experimental Zoology, 133
R. Winklbauer, Ray Keller (1996)
Fibronectin, mesoderm migration, and gastrulation in Xenopus.Developmental biology, 177 2
L. Dale, J. Smith, J. Slack (1985)
Mesoderm induction in Xenopus laevis: a quantitative study using a cell lineage label and tissue-specific antibodies.Journal of embryology and experimental morphology, 89
D. Onichtchouk, V. Gawantka, R. Dosch, H. Delius, K. Hirschfeld, C. Blumenstock, C. Niehrs (1996)
The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controling dorsoventral patterning of Xenopus mesodermDevelopment, 122
J. Behrens, J. Kries, M. Kühl, L. Bruhn, D. Wedlich, R. Grosschedl, W. Birchmeier (1996)
Functional interaction of β-catenin with the transcription factor LEF-1Nature, 382
John Merriam, Adam Rubenstein, M. Klymkowsky (1997)
Cytoplasmically anchored plakoglobin induces a WNT-like phenotype in Xenopus.Developmental biology, 185 1
E. Robertis, Y. Sasai (1996)
A common plan for dorsoventral patterning in BilateriaNature, 380
S. Yuan, D. Darnell, G. Schoenwolf (1995)
Mesodermal patterning during avian gastrulation and neurulation: experimental induction of notochord from non-notochordal precursor cells.Developmental genetics, 17 1
Teresa Lamb, R. Harland (1995)
Fibroblast growth factor is a direct neural inducer, which combined with noggin generates anterior-posterior neural pattern.Development, 121 11
J. Slack (1994)
Inducing factors in Xenopus early embryosCurrent Biology, 4
Lester Barth, L. Barth (1974)
Ionic regulation of embryonic induction and cell differentiation in Rana pipiens.Developmental biology, 39 1
T. Doniach, C. Phillips, J. Gerhart (1992)
Planar induction of anteroposterior pattern in the developing central nervous system of Xenopus laevis.Science, 257 5069
D. Frank, R. Harland (1991)
Transient expression of XMyoD in non-somitic mesoderm of Xenopus gastrulae.Development, 113 4
Jeremy Green, T. Cook, James Smith, R. Grainger (1997)
Anteroposterior neural tissue specification by activin-induced mesoderm.Proceedings of the National Academy of Sciences of the United States of America, 94 16
A. Tucker, J. Slack (1995)
Tail bud determination in the vertebrate embryoCurrent Biology, 5
J. Saint-Jeannet, I. Dawid (1994)
Vertical versus planar neural induction in Rana pipiens embryos.Proceedings of the National Academy of Sciences of the United States of America, 91
D. Darnell, G. Schoenwolf, C. Ordahl (1992)
Changes in dorsoventral but not rostrocaudal regionalization of the chick neural tube in the absence of cranial notochord, as revealed by expression of Engrailed‐2Developmental Dynamics, 193
D. Kimelman, J. Abraham, T. Haaparanta, T. Palisi, M. Kirschner (1988)
The presence of fibroblast growth factor in the frog egg: its role as a natural mesoderm inducer.Science, 242 4881
Xi He, J. Saint-Jeannet, J. Woodgett, H. Varmus, I. Dawid (1995)
Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryosNature, 374
C. Yost, M. Torres, Jeffrey Miller, Eugene Huang, D. Kimelman, R. Moon (1996)
The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.Genes & development, 10 12
Carole LaBonne, Malcolm Whitman (1997)
Localization of MAP kinase activity in early Xenopus embryos: implications for endogenous FGF signaling.Developmental biology, 183 1
S. Godsave, J. Slack (1991)
Single cell analysis of mesoderm formation in the Xenopus embryo.Development, 111 2
J. Cooke (1985)
Dynamics of the control of body pattern in the development of Xenopus laevis. III. Timing and pattern after u.v. irradiation of the egg and after excision of presumptive head endo-mesoderm.Journal of embryology and experimental morphology, 88
P. Thomas, R. Beddington (1996)
Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryoCurrent Biology, 6
S. Piccolo, Y. Sasai, B. Lu, E. Robertis (1996)
Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4Cell, 86
R. Gimlich, John Gerhart (1984)
Early cellular interactions promote embryonic axis formation in Xenopus laevis.Developmental biology, 104 1
L. Leyns, T. Bouwmeester, Sung-Hyun Kim, S. Piccolo, E. Robertis (1997)
Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann OrganizerCell, 88
J. Green, H. New, James Smith (1992)
Responses of embryonic xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesodermCell, 71
S. Hawley, K. Wunnenberg-Stapleton, C. Hashimoto, M. Laurent, T. Watabe, B. Blumberg, K. Cho (1995)
Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.Genes & development, 9 23
R. Keller, J. Shih, C. Domingo (1992)
Pintallavis, a gene expressed in the organizer and midline cells of frog embryos: involvement in the development of the neural axis.Development, 116
H. Sive, L. Bradley (1996)
A sticky problem: The Xenopus cement gland as a paradigm for anteroposterior patterningDevelopmental Dynamics, 205
R. Keller, J. Hardin (1987)
Cell Behaviour During Active Cell Rearrangement: Evidence and SpeculationsJournal of Cell Science, 1987
M. Sakai (1996)
The vegetal determinants required for the Spemann organizer move equatorially during the first cell cycle.Development, 122 7
M. Fujisue, Y. Kobayakawa, K. Yamana (1993)
Occurrence of dorsal axis-inducing activity around the vegetal pole of an uncleaved Xenopus egg and displacement to the equatorial region by cortical rotation.Development, 118 1
I. Dawid, T. Sargent (1988)
Xenopus laevis in developmental and molecular biology.Science, 240 4858
W. Smith, R. Harland (1991)
Injected Xwnt-8 RNA acts early in Xenopus embryos to promote formation of a vegetal dorsalizing centerCell, 67
C. Jones, L. Dale, B. Hogan, C. Wright, J. Smith (1996)
Bone morphogenetic protein-4 (BMP-4) acts during gastrula stages to cause ventralization of Xenopus embryos.Development, 122 5
J. Slack, H. Isaacs (1989)
Presence of basic fibroblast growth factor in the early Xenopus embryo
P. Hoodless, T. Haerry, S. Abdollah, M. Stapleton, M. O’Connor, L. Attisano, J. Wrana (1996)
MADR1, a MAD-Related Protein That Functions in BMP2 Signaling PathwaysCell, 85
L. Gamer, C. Wright (1995)
Autonomous endodermal determination in Xenopus: regulation of expression of the pancreatic gene XlHbox 8.Developmental biology, 171 1
Noriko Funayama, François Fagotto, P. McCrea, B. Gumbiner (1995)
Embryonic axis induction by the armadillo repeat domain of beta- catenin: evidence for intracellular signalingThe Journal of Cell Biology, 128
G. Schoenwolf, V. García-Martínez, M. Dias (1992)
Mesoderm movement and fate during avian gastrulation and neurulationDevelopmental Dynamics, 193
R. Gimlich (1986)
Acquisition of developmental autonomy in the equatorial region of the Xenopus embryo.Developmental biology, 115 2
M. Köster, S. Plessow, J. Clement, A. Lorenz, H. Tiedemann, W. Knöchel (1991)
Bone morphogenetic protein 4 (BMP-4), a member of the TGF-β family, in early embryos of Xenopus laevis: analysis of mesoderm inducing activityMechanisms of Development, 33
Carmen Domingo, Ray Keller (1995)
Induction of notochord cell intercalation behavior and differentiation by progressive signals in the gastrula of Xenopus laevis.Development, 121 10
Terry Tang, R. Freeman, A. O’Reilly, B. Neel, S. Sokol (1995)
The SH2-containing protein-tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early xenopus developmentCell, 80
J. Gerhart, M. Danilchik, T. Doniach, S. Roberts, B. Rowning, R. Stewart (1989)
Cortical rotation of the Xenopus egg: consequences for the anteroposterior pattern of embryonic dorsal development.Development, 107 Suppl
K. Nübler-Jung, D. Arendt (1997)
Is ventral in insects dorsal in vertebrates, 203
Delphine Psychoyos, Claudio Stern (1996)
Restoration of the organizer after radical ablation of Hensen's node and the anterior primitive streak in the chick embryo.Development, 122 10
R. Gimlich, J. Cooke (1983)
Cell lineage and the induction of second nervous systems in amphibian developmentNature, 306
M. Matzuk, Na Lu, H. Vogel, K. Sellheyer, D. Roop, A. Bradley (1995)
Multiple defects and perinatal death in mice deficient in follistatinNature, 374
R. Friesel, I. Dawid (1991)
cDNA cloning and developmental expression of fibroblast growth factor receptors from Xenopus laevisMolecular and Cellular Biology, 11
A. Chitnis, D. Henrique, Julian Lewis, D. Ish-Horowicz, C. Kintner (1995)
Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene DeltaNature, 375
R. Xu, J. Kim, M. Taira, S. Zhan, D. Sredni, H. Kung (1995)
A dominant negative bone morphogenetic protein 4 receptor causes neuralization in Xenopus ectoderm.Biochemical and biophysical research communications, 212 1
Min Ku, D. Melton (1993)
Xwnt-11: a maternally expressed Xenopus wnt gene.Development, 119 4
D. Kimelman, J Christian, R. Moon (1992)
Synergistic principles of development: overlapping patterning systems in Xenopus mesoderm induction.Development, 116 1
Y. Sasai, B. Lu, S. Piccolo, E. Robertis (1996)
Endoderm induction by the organizer‐secreted factors chordin and noggin in Xenopus animal caps.The EMBO Journal, 15
H. Kageura (1990)
Spatial distribution of the capacity to initiate a secondary embryo in the 32-cell embryo of Xenopus laevis.Developmental biology, 142 2
E. Amaya, T. Musci, M. Kirschner (1991)
Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in xenopus embryosCell, 66
S. Ekker, L. McGrew, Cheng-Jung Lai, John Lee, D. Kessler, R. Moon, P. Beachy (1995)
Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis.Development, 121 8
S. Pierce, D. Kimelman (1995)
Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3.Development, 121 3
P. Nieuwkoop, B. Albers (1990)
The Role of Competence in the Cranio‐Caudal Segregation of the Central Nervous SystemDevelopment, 32
M. Donoghue, B. Patton, J. Sanes, J. Merlie (1992)
An axial gradient of transgene methylation in murine skeletal muscle: genomic imprint of rostrocaudal position.Development, 116 4
W. Talbot, B. Trevarrow, M. Halpern, A. Melby, G. Farr, J. Postlethwait, T. Jowett, C. Kimmel, D. Kimelman (1995)
A homeobox gene essential for zebrafish notochord developmentNature, 378
Daniel Kessler, Douglas Melton (1995)
Induction of dorsal mesoderm by soluble, mature Vg1 protein.Development, 121 7
E. Amaya, P. Stein, T. Musci, M. Kirschner (1993)
FGF signalling in the early specification of mesoderm in Xenopus.Development, 118 2
H. Isaacs, M. Pownall, Jonathan Slack (1994)
eFGF regulates Xbra expression during Xenopus gastrulation.The EMBO Journal, 13
A. Hemmati‐Brivanlou, O. Kelly, D. Melton (1994)
Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activityCell, 77
A. Hemmati‐Brivanlou, G. Thomsen (1995)
Ventral mesodermal patterning in Xenopus embryos: expression patterns and activities of BMP-2 and BMP-4.Developmental genetics, 17 1
G. Thomsen, D. Melton (1993)
Processed Vg1 protein is an axial mesoderm inducer in xenopusCell, 74
H. Isaacs, D. Tannahill, J. Slack (1992)
Expression of a novel FGF in the Xenopus embryo. A new candidate inducing factor for mesoderm formation and anteroposterior specification.Development, 114 3
Wm. Cox, A. Hemmati‐Brivanlou (1995)
Caudalization of neural fate by tissue recombination and bFGF.Development, 121 12
J. Slack, B. Darlington, J. Heath, S. Godsave (1987)
Mesoderm induction in early Xenopus embryos by heparin-binding growth factorsNature, 326
K. Symes, James Smith (1987)
Gastrulation movements provide an early marker of mesoderm induction in Xenopus laevisDevelopment, 101
R. Harland (1994)
Neural induction in Xenopus.Current opinion in genetics & development, 4 4
Atsushi Suzuki, R. THIESt, Noboru YAMAJIt, Jeffrey SONGt, John WOZNEYt, Kazuo Murakami, Naoto, Ueno (1994)
A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.Proceedings of the National Academy of Sciences of the United States of America, 91 22
P. Nieuwkoop, K. Koster (1995)
Vertical versus planar induction in amphibian early developmentDevelopment, 37
James Smith, B. Price, J. Green, D. Weigel, B. Herrmann (1991)
Expression of a xenopus homolog of Brachyury (T) is an immediate-early response to mesoderm inductionCell, 67
J. Gurdon, A. Mitchell, Kenneth Ryan (1996)
An experimental system for analyzing response to a morphogen gradient.Proceedings of the National Academy of Sciences of the United States of America, 93 18
H. Steinbeisser, A. Fainsod, C. Niehrs, Y. Sasai, E. Robertis (1995)
The role of gsc and BMP‐4 in dorsal‐ventral patterning of the marginal zone in Xenopus: a loss‐of‐function study using antisense RNA.The EMBO Journal, 14
T. Holowacz, R. Elinson (1995)
Properties of the dorsal activity found in the vegetal cortical cytoplasm of Xenopus eggs.Development, 121 9
Stephan Schneider, H. Steinbeisser, R. Warga, P. Hausen (1996)
β-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryosMechanisms of Development, 57
J. Christian, D. Olson, R. Moon (1992)
Xwnt‐8 modifies the character of mesoderm induced by bFGF in isolated Xenopus ectoderm.The EMBO Journal, 11
M. Whitman, D. Melton (1992)
Involvement of p21ras in Xenopus mesoderm inductionNature, 357
I. Blitz, K. Cho (1995)
Anterior neurectoderm is progressively induced during gastrulation: the role of the Xenopus homeobox gene orthodenticle.Development, 121 4
J. Moury, A. Jacobson (1990)
The origins of neural crest cells in the axolotl.Developmental biology, 141 2
M. Kengaku, H. Okamoto (1995)
bFGF as a possible morphogen for the anteroposterior axis of the central nervous system in Xenopus.Development, 121 9
Stephan Hoppler, Jeffrey Brown, R. Moon (1996)
Expression of a dominant-negative Wnt blocks induction of MyoD in Xenopus embryos.Genes & development, 10 21
W. Smith, Anne Knecht, Mike Wu, R. Harland (1993)
Secreted noggin protein mimics the Spemann organizer in dorsalizing Xenopus mesodermNature, 361
R. Keller (1976)
Vital dye mapping of the gastrula and neurula of Xenopus laevis: I. Prospective areas and morphogenetic movements of the superficial layerDevelopmental Biology, 51
V. Gawantka, Hajo Delius, K. Hirschfeld, C. Blumenstock, Christof Niehrs (1995)
Antagonizing the Spemann organizer: role of the homeobox gene Xvent‐1.The EMBO Journal, 14
Rodolpho Albano, R. Arkell, R. Beddington, James Smith (1994)
Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain.Development, 120 4
E. Ferguson, K. Anderson (1992)
Localized enhancement and repression of the activity of the TGF-beta family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo.Development, 114 3
I. Kaneda (1981)
Studies on the Formation and State of Determination of the Trunk Organizer in the Newt, Cynops Pyrrhogaster III. Tangential Induction in the Dorsal Marginal ZoneDevelopment, 23
J. Baker, R. Harland (1996)
A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.Genes & development, 10 15
Carole LaBonne, Malcolm Whitman (1994)
Mesoderm induction by activin requires FGF-mediated intracellular signals.Development, 120 2
J. Cooke, J. Smith (1987)
The midblastula cell cycle transition and the character of mesoderm in u.v.-induced nonaxial Xenopus development.Development, 99 2
Gerald Thomsen, Tod Woolf, Malcolm Whitman, Sergei Sokol, J. Vaughan, Wylie Vale, Douglas Melton (1990)
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structuresCell, 63
L. Barth (1941)
Neural differentiation without organizerJournal of Experimental Zoology, 87
R. Cornell, T. Musci, D. Kimelman (1995)
FGF is a prospective competence factor for early activin-type signals in Xenopus mesoderm induction.Development, 121 8
J. Slack, H. Isaacs (1989)
Presence of basic fibroblast growth factor in the early embryoDevelopment, 105
Carole LaBonne, Brenda Burke, Malcolm Whitman (1995)
Role of MAP kinase in mesoderm induction and axial patterning during Xenopus development.Development, 121 5
J. Christian, J. McMahon, A. McMahon, R. Moon (1991)
Xwnt-8, a Xenopus Wnt-1/int-1-related gene responsive to mesoderm-inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis.Development, 111 4
S. Dyson, J. Gurdon (1997)
Activin signalling has a necessary function in Xenopus early developmentCurrent Biology, 7
R. Cornell, D. Kimelman (1994)
Activin-mediated mesoderm induction requires FGF.Development, 120 2
F. Rosa, A. Roberts, D. Danielpour, L. Dart, M. Sporn, I. Dawid (1988)
Mesoderm induction in amphibians: the role of TGF-beta 2-like factors.Science, 239 4841 Pt 1
Nanette Nascone, M. Mercola (1995)
An inductive role for the endoderm in Xenopus cardiogenesis.Development, 121 2
Fang Liu, A. Hata, J. Baker, J. Doody, J. Cárcamo, R. Harland, J. Massagué (1996)
A human Mad protein acting as a BMP-regulated transcriptional activatorNature, 381
C. Niehrs, H. Steinbeisser, E. Robertis (1994)
Mesodermal patterning by a gradient of the vertebrate homeobox gene goosecoid.Science, 263 5148
S. Sokol (1996)
Analysis of Dishevelled signalling pathways during Xenopus developmentCurrent Biology, 6
Y. Sasai, B. Lu, H. Steinbeisser, E. Robertis (1995)
Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in XenopusNature, 376
J. Graff, R. Thies, Jeffrey Song, A. Celeste, D. Melton (1994)
Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivoCell, 79
Yoshiki Sasai, Y. Sasai, E. Robertis (1997)
Ectodermal patterning in vertebrate embryos.Developmental biology, 182 1
M. Dirksen, Milan Jamrich (1992)
A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain.Genes & development, 6 4
B. Youn, G. Malacinski (1981)
Axial structure development in ultraviolet-irradiated (notochord-defective) amphibian embryos.Developmental biology, 83 2
E. Jones, H. Woodland (1987)
The development of animal cap cells in Xenopus: a measure of the start of animal cap competence to form mesodermDevelopment, 101
I. Varlet, J. Collignon, E. Robertson (1997)
nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation.Development, 124 5
Tetsuro Watabe, Sam Kim, Albert Candia, Ute Rothb, C. Hashimoto, Kunio Inoue, K. Cho (1995)
Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse.Genes & development, 9 24
R. Elinson, B. Rowning (1988)
A transient array of parallel microtubules in frog eggs: potential tracks for a cytoplasmic rotation that specifies the dorso-ventral axis.Developmental biology, 128 1
M. Halpern, R. Ho, C. Walker, C. Kimmel (1993)
Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutationCell, 75
T. Musci, E. Amaya, M. Kirschner (1990)
Regulation of the fibroblast growth factor receptor in early Xenopus embryos.Proceedings of the National Academy of Sciences of the United States of America, 87
O. Pourquié, C. Fan, M. Coltey, E. Hirsinger, Yuji Watanabe, C. Bréant, P. Francis-West, P. Brickell, M. Tessier-Lavigne, N. Douarin (1996)
Lateral and Axial Signals Involved in Avian Somite Patterning: A Role for BMP4Cell, 84
I. Dominguez, K. Itoh, S. Sokol (1995)
Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.Proceedings of the National Academy of Sciences of the United States of America, 92 18
R. Keller, J. Shih, A. Sater, Cecelia Moreno (1992)
Planar induction of convergence and extension of the neural plate by the organizer of XenopusDevelopmental Dynamics, 193
M. Lane, R. Keller (1997)
Microtubule disruption reveals that Spemann's organizer is subdivided into two domains by the vegetal alignment zone.Development, 124 4
W. Smith, R. Harland (1992)
Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryosCell, 70
Karlyne Reilly, D. Melton (1996)
Short-Range Signaling by Candidate Morphogens of the TGFβ Family and Evidence for a Relay Mechanism of InductionCell, 86
J. Holtfreter (1951)
Some aspects of embryonic induction.Growth, Suppl 10
J. Boucaut, L. Clavilier, T. Darribère, M. Delarue, J. Riou, D. Shi (1996)
What mechanisms drive cell migration and cell interactions in Pleurodeles?The International journal of developmental biology, 40 4
Leslie Dale, J. Slack (1987)
Regional specification within the mesoderm of early embryos of Xenopus laevis.Development, 100 2
L. McGrew, Cheng-Jung Lai, R. Moon (1995)
Specification of the anteroposterior neural axis through synergistic interaction of the Wnt signaling cascade with noggin and follistatin.Developmental biology, 172 1
Daniel Kessler, Douglas Melton (1994)
Vertebrate embryonic induction: mesodermal and neural patterning.Science, 266 5185
J. Green, G. Howes, K. Symes, J. Cooke, James Smith (1990)
The biological effects of XTC-MIF: quantitative comparison with Xenopus bFGF.Development, 108 1
A. Suzuki, Yuriko Mifune, T. Kanéda (1984)
Germ Layer Interactions in Pattern Formation of Amphibian Mesoderm during Primary Embryonic InductionDevelopment, 26
A. Suzuki, N. Shioda, N. Ueno (1995)
Bone morphogenetic protein acts as a ventral mesoderm modifier in early Xenopus embryosDevelopment, 37
H. Spemann (1938)
Embryonic development and induction
Xin Chen, M. Rubock, M. Whitman (1996)
A transcriptional partner for MAD proteins in TGF-β signallingNature, 383
Yael Re'em‐Kalma, Teresa Lamb, Dale Frank (1995)
Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development.Proceedings of the National Academy of Sciences of the United States of America, 92 26
M. Bolce, A. Hemmati‐Brivanlou, P. Kushner, R. Harland (1992)
Ventral ectoderm of Xenopus forms neural tissue, including hindbrain, in response to activin.Development, 115 3
N. Hopwood, A. Pluck, J. Gurdon (1989)
MyoD expression in the forming somites is an early response to mesoderm induction in Xenopus embryos.The EMBO Journal, 8
B. Albers (1987)
Competence as the Main Factor Determining the Size of the Neural PlateDevelopment, 29
C. Larabell, M. Torres, B. Rowning, C. Yost, Jeffrey Miller, Mike Wu, D. Kimelman, R. Moon (1997)
Establishment of the Dorso-ventral Axis in Xenopus Embryos Is Presaged by Early Asymmetries in β-Catenin That Are Modulated by the Wnt Signaling PathwayThe Journal of Cell Biology, 136
P. Wilson, D. Melton (1994)
Mesodermal patterning by an inducer gradient depends on secondary cell–cell communicationCurrent Biology, 4
H. Isaacs, M. Pownall, Jonathan Slack (1995)
eFGF is expressed in the dorsal midline of Xenopus laevis.The International journal of developmental biology, 39 4
D. Kimelman, M. Kirschner (1987)
Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryoCell, 51
A. Hemmati‐Brivanlou, D. Melton (1992)
A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryosNature, 359
J. Shih, R. Keller (1992)
Cell motility driving mediolateral intercalation in explants of Xenopus laevis.Development, 116 4
J. Holtfreter (1947)
Neural induction in explants which have passed through a sublethal cytolysis.The Journal of experimental zoology, 106 2
F. Stennard, G. Carnac, J. Gurdon (1996)
The Xenopus T-box gene, Antipodean, encodes a vegetally localised maternal mRNA and can trigger mesoderm formation.Development, 122 12
George Dassow, J. Schmidt, D. Kimelman (1993)
Induction of the Xenopus organizer: expression and regulation of Xnot, a novel FGF and activin-regulated homeo box gene.Genes & development, 7 3
J Christian, R. Moon (1993)
Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus.Genes & development, 7 1
C. Dohrmann, D. Kessler, D. Melton (1996)
Induction of axial mesoderm by zDVR-1, the zebrafish orthologue of Xenopus Vg1.Developmental biology, 175 1
Yanzhen Cui, Jeffrey Brown, R. Moon, J Christian (1995)
Xwnt-8b: a maternally expressed Xenopus Wnt gene with a potential role in establishing the dorsoventral axis.Development, 121 7
H. Holtfreter-Ban (1965)
Differentiation capacities of Spemann's organizer investigated in explants of diminishing size
S. Schulte-Merker, James Smith (1995)
Mesoderm formation in response to Brachyury requires FGF signallingCurrent Biology, 5
J. Heasman, A. Crawford, K. Goldstone, P. Garner-Hamrick, B. Gumbiner, P. McCrea, C. Kintner, Chikako Noro, C. Wylie (1994)
Overexpression of cadherins and underexpression of β-catenin inhibit dorsal mesoderm induction in early Xenopus embryosCell, 79
Jeremy Green, James Smith, John Gerhart (1994)
Slow emergence of a multithreshold response to activin requires cell-contact-dependent sharpening but not prepattern.Development, 120 8
H. Yamashita, Peter DUke, Danny Huylebroeck, T. Sampath, M. Andries, James Smith, C. Heldin, K. Miyazono (1995)
Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effectsThe Journal of Cell Biology, 130
S. Sokol, J. Christian, R. Moon, D. Melton (1991)
Injected Wnt RNA induces a complete body axis in Xenopus embryosCell, 67
▪ Abstract The organizer is formed in an equatorial sector of the blastula stage amphibian embryo by cells that have responded to two maternal agents: a general meso-endoderm inducer (involving the TFG-β signaling pathway) and a dorsal modifier (probably involving the Wnt signaling pathway). The meso-endoderm inducer is secreted by most vegetal cells, those containing maternal materials that had been localized in the vegetal hemisphere of the oocyte during oogenesis. As a consequence of the inducer's distribution and action, the competence domains of prospective ectoderm, mesoderm, and endoderm are established in an animal-to-vegetal order in the blastula. The dorsal modifier signal is secreted by a sector of cells of the animal and vegetal hemispheres on one side of the blastula. These cells contain maternal materials transported there in the first cell cycle from the vegetal pole of the egg along microtubules aligned by cortical rotation. The Nieuwkoop center is the region of blastula cells secreting both maternal signals, and hence specifying the organizer in an equatorial sector. Final steps of organizer formation at the late blastula or early gastrula stage may involve locally secreted zygotic signals as well. At the gastrula stage, the organizer secretes a variety of zygotic proteins that act as antagonists to various members of the BMP and Wnt families of ligands, which are secreted by cells of the competence domains surrounding the organizer. BMPs and Wnts favor ventral development, and cells near the organizer are protected from these agents by the organizer's inducers. The nearby cells are derepressed in their inherent capacity for dorsal development, which is apparent in the neural induction of the ectoderm, dorsalization of the mesoderm, and anteriorization of the endoderm. The organizer also engages in extensive specialized morphogenesis, which brings it within range of responsive cell groups. It also self-differentiates to a variety of axial tissues of the body.
Annual Review of Cell and Developmental Biology – Annual Reviews
Published: Nov 1, 1997
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