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Hideo Negishi, Y. Ohba, H. Yanai, A. Takaoka, K. Honma, K. Yui, T. Matsuyama, T. Taniguchi, K. Honda (2005)
Negative regulation of Toll-like-receptor signaling by IRF-4.Proceedings of the National Academy of Sciences of the United States of America, 102 44
A. Takaoka, H. Yanai, S. Kondo, G. Duncan, Hideo Negishi, T. Mizutani, S. Kano, K. Honda, Y. Ohba, T. Mak, T. Taniguchi (2005)
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptorsNature, 434
K. Ogasawara, S. Hida, N. Azimi, Y. Tagaya, Takeo Sato, Taeko Yokochi-Fukuda, T. Waldmann, T. Taniguchi, S. Taki (1998)
Requirement for IRF-1 in the microenvironment supporting development of natural killer cellsNature, 391
K. Honda, Y. Ohba, H. Yanai, Hideo Negishi, T. Mizutani, A. Takaoka, C. Taya, T. Taniguchi (2005)
Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon inductionNature, 434
Hideo Negishi, Yasuyuki Fujita, H. Yanai, S. Sakaguchi, Xinshou Ouyang, M. Shinohara, H. Takayanagi, Y. Ohba, T. Taniguchi, K. Honda (2006)
Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction programProceedings of the National Academy of Sciences, 103
C. Guiducci, G. Ott, Jean Chan, E. Damon, C. Calacsan, T. Matray, Kyung-Dall Lee, R. Coffman, F. Barrat (2006)
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activationThe Journal of Experimental Medicine, 203
F. Schmitz, A. Heit, S. Guggemoos, A. Krug, J. Mages, M. Schiemann, H. Adler, I. Drexler, T. Haas, R. Lang, H. Wagner (2007)
Interferon‐regulatory‐factor 1 controls Toll‐like receptor 9‐mediated IFN‐β production in myeloid dendritic cellsEuropean Journal of Immunology, 37
K. Takeda, S. Akira (2004)
Toll-like receptors in innate immunity.International immunology, 17 1
K. Honda, T. Taniguchi (2006)
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptorsNature Reviews Immunology, 6
K. Honda, H. Yanai, Hideo Negishi, M. Asagiri, Mitsuharu Sato, T. Mizutani, Naoya Shimada, Y. Ohba, A. Takaoka, N. Yoshida, T. Taniguchi (2005)
IRF-7 is the master regulator of type-I interferon-dependent immune responsesNature, 434
Schmitz Schmitz, Heit Heit, Guggemoos Guggemoos, Krug Krug, Mages Mages, Schiemann Schiemann, Adler Adler (2007)
Interferon‐regulatory‐factor 1 controls toll‐like‐receptor 9 mediated interferon‐beta production in myeloid dendritic cells.Eur. J. Immunol, 37
TLR trigger the induction of type I IFN (IFN‐alpha/beta), providing a crucial mechanism of anti‐viral defense. Until recently, TLR were thought to induce type I IFN responses by activating two transcription factors which belong to the IFN‐regulatory factor (IRF) family, IRF‐3 and IRF‐7. TLR‐3 and TLR‐4 induce IFN‐beta by activating IRF‐3; TLR‐9 induces IFN‐alpha and IFN‐beta through IRF‐7, at least when engaged by type A CpG oligonucleotides (CpG‐A) in plasmacytoid DC (pDC). In this issue of the European Journal of Immunology, it is demonstrated that TLR‐9 induces IFN‐beta when engaged by type B CpG oligonucleotides (CpG‐B) in myeloid DC and macrophages. Remarkably, this response is independent of IRF‐3/7 and, in fact, requires another IRF family member, IRF‐1. IRF‐1 is recruited by TLR‐9 through the adaptor MyD88. Deficiency of the TLR‐9→IRF‐1→IFN‐beta pathway results in impaired anti‐viral responses not only in vitro but also in vivo. These results demonstrate that TLR induce IFN‐alpha or IFN‐beta responses by activating distinct IRF, depending on the TLR ligand and the cell type. These distinct TLR‐IRF pathways may allow the immune system to tailor its responses to viral pathogens. See accompanying article http://dx.doi.org/10.1002/eji.200636767
European Journal of Immunology – Wiley
Published: Feb 1, 2007
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