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GENETICS OF NERVOUS SYSTEM DISEASES NEUROREPORT Family-based association study between G72/G30 genetic polymorphism and schizophrenia a,b d d c,e a,b Chen-Jee Hong , Sheue-Jane Hou ,Feng-Chang Yen ,Ying-Jay Liou and Shih-Jen Tsai a b c Department of Psychiatry,Taipei Veterans General Hospital, Division of Psychiatry, Institute of Clinical Medicine, School of Medicine, National Yang-Ming d e University, Division of Psychiatry,Cheng-Hsin Rehabilitation and Medical Center,Taipei and Department of Psychiatry,Yuli Veterans Hospital, Hualien,Taiwan Correspondence and requests for reprints to Dr Shih-JenTsai, MD, Department of Psychiatry,Taipei Veterans General Hospital, No. 201Shih-Pai Road, Sec. 2, Taipei 11217, Taiwan Tel: 886 2 2875 7027; fax: 886 2 2872 5643; e-mail: [email protected] There are no con£icts of interest. Sponsorship:This work was supported by Grant 92-2314-B-075-087 from the National Science Council,Taiwan, ROC, and Grant VGH90-238 from theTaipei Veterans General Hospital. Received 3 March 2006; accepted 24 April 2006 Genetic variations in G72/G30 have been reported to be associated signi¢cant association between the G72/G30 rs947267 polymorph- with schizophrenia and bipolar disorders in several case^ control ism and schizophrenia (P¼0.016), with the A allele more commonly studies.This gene is located in a genomic region known to contain transmitted to patients. Further analysis strati¢ed by sex showed susceptibility genes for
Neuroreport – Wolters Kluwer Health
Published: Jul 1, 2006
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