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Effect of hypercorticism on regulation of skeletal muscle glycogen metabolism by insulin

Effect of hypercorticism on regulation of skeletal muscle glycogen metabolism by insulin JEAN-LOUIS CHIASSON Research Group on Diabetes Metabolic , Clinical Research Institute Montreal Department Medicine, University Montreal, Montreal, Quebec H2 W 1R?, Canada Coderre, Lise, Ashok K. Srivastava, Jean-Louis Chiasson. Effect on skeletal . Am. J. Physiol. 262 (Endocrinol. Metab. 25): E427-E433, 1992.-The effects on the in skeletal s was examined using the hindlimb perfusion technique. Rats were injected daily with either saline or dexamethasone (0.4 mg. kg-lo day-‘) for 14 days were studied in the fed or (24 h) state under saline or (1 mu/ml) treatment. In fed controls, resulted in synthase activation in enhanced synthesis. In dexamethasone-treated animals, basal concentration remained normal, but synthase activity ratio was decreased in white red gastrocnemius plantaris s. Furthermore, failed to activate synthase synthesis. In the controls, fasting was associated with decreased concentrations with increased synthase activity ratio in all four groups s (P < 0.01). Dexamethasone treatment, however, completely abolished the decrease in content as well as the augmented synthase activity ratio associated with fasting. infusion stimulated synthesis in controls but not in dexamethasone-treated rats. These data therefore indicate that dexamethasone treatment inhibits the stimulatory effect on synthase activity on synthesis. Furthermore, suppresses the decrease in content associated with fasting. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AJP - Endocrinology and Metabolism The American Physiological Society

Effect of hypercorticism on regulation of skeletal muscle glycogen metabolism by insulin

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Publisher
The American Physiological Society
Copyright
Copyright © 1992 the American Physiological Society
ISSN
0193-1849
eISSN
1522-1555
Publisher site
See Article on Publisher Site

Abstract

JEAN-LOUIS CHIASSON Research Group on Diabetes Metabolic , Clinical Research Institute Montreal Department Medicine, University Montreal, Montreal, Quebec H2 W 1R?, Canada Coderre, Lise, Ashok K. Srivastava, Jean-Louis Chiasson. Effect on skeletal . Am. J. Physiol. 262 (Endocrinol. Metab. 25): E427-E433, 1992.-The effects on the in skeletal s was examined using the hindlimb perfusion technique. Rats were injected daily with either saline or dexamethasone (0.4 mg. kg-lo day-‘) for 14 days were studied in the fed or (24 h) state under saline or (1 mu/ml) treatment. In fed controls, resulted in synthase activation in enhanced synthesis. In dexamethasone-treated animals, basal concentration remained normal, but synthase activity ratio was decreased in white red gastrocnemius plantaris s. Furthermore, failed to activate synthase synthesis. In the controls, fasting was associated with decreased concentrations with increased synthase activity ratio in all four groups s (P < 0.01). Dexamethasone treatment, however, completely abolished the decrease in content as well as the augmented synthase activity ratio associated with fasting. infusion stimulated synthesis in controls but not in dexamethasone-treated rats. These data therefore indicate that dexamethasone treatment inhibits the stimulatory effect on synthase activity on synthesis. Furthermore, suppresses the decrease in content associated with fasting.

Journal

AJP - Endocrinology and MetabolismThe American Physiological Society

Published: Apr 1, 1992

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