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L. Martínez, T. Kekarainen, M. Sibila, F. Ruiz-Fons, D. Vidal, C. Gortázar, J. Segalés (2006)
Torque teno virus (TTV) is highly prevalent in the European wild boar (Sus scrofa).Veterinary microbiology, 118 3-4
S. Krakowka, Catherine Hartunian, Alexander Hamberg, D. Shoup, M. Rings, Yan Zhang, G. Allan, J. Ellis (2008)
Evaluation of induction of porcine dermatitis and nephropathy syndrome in gnotobiotic pigs with negative results for porcine circovirus type 2.American journal of veterinary research, 69 12
T. Kekarainen, M. Sibila, J. Segalés (2006)
Prevalence of swine Torque teno virus in post-weaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs in Spain.The Journal of general virology, 87 Pt 4
H. Okamoto, Masaharu Takahashi, T. Nishizawa, M. Ukita, M. Fukuda, F. Tsuda, Yuzo Miyakawa, Makoto Mayumi (1999)
Marked genomic heterogeneity and frequent mixed infection of TT virus demonstrated by PCR with primers from coding and noncoding regions.Virology, 259 2
J. Vinetz (2002)
A diagnostic guideTrends in Parasitology, 18
F. Maggi, M. Pifferi, C. Fornai, E. Andreoli, E. Tempestini, M. Vatteroni, S. Presciuttini, S. Marchi, A. Pietrobelli, A. Boner, M. Pistello, M. Bendinelli (2003)
TT Virus in the Nasal Secretions of Children with Acute Respiratory Diseases: Relations to Viremia and Disease SeverityJournal of Virology, 77
P. Gergely, A. Perl, G. Poór (2006)
Possible pathogenic nature of the recently discovered TT virus: does it play a role in autoimmune rheumatic diseases?Autoimmunity reviews, 6 1
M Takács, A Dencs, C Csiszár, A Hettmann, E Rusvai, KN Zomor, V Pálfi, B Nagy (2008)
First Description of swine torque teno Virus (ttv) and detection of a new genogroup in HungaryActa Veterinaria Hungarica, 56
F. Maggi, M. Pifferi, E. Tempestini, C. Fornai, L. Lanini, E. Andreoli, M. Vatteroni, S. Presciuttini, A. Pietrobelli, A. Boner, M. Pistello, M. Bendinelli (2003)
TT Virus Loads and Lymphocyte Subpopulations in Children with Acute Respiratory DiseasesJournal of Virology, 77
M. Charlton, P. Adjei, J. Poterucha, N. Zein, Breanndan Moore, T. Therneau, R. Krom, R. Wiesner (1998)
TT‐virus infection in north american blood donors, patients with fulminant hepatic failure, and cryptogenic cirrhosisHepatology, 28
I. Davidson, L. Shulman (2008)
Unraveling the puzzle of human anellovirus infections by comparison with avian infections with the chicken anemia virus.Virus research, 137 1
H. Okamoto (2010)
[Torque teno virus].Nihon rinsho. Japanese journal of clinical medicine, 68 Suppl 6
C. Rosell, J. Segalés, M. Domingo (2000)
Hepatitis and Staging of Hepatic Damage in Pigs Naturally Infected with Porcine Circovirus Type 2Veterinary Pathology, 37
J. Erker, S. Desai, I. Mushahwar (1999)
Rapid detection of Hepatitis E virus RNA by reverse transcription-polymerase chain reaction using universal oligonucleotide primers.Journal of virological methods, 81 1-2
LD Sims (1996)
Pathology of the Pig
Margarita Martín, J. Segalés, F. Huang, D. Guenette, E. Mateu, N. Deus, X. Meng (2007)
Association of hepatitis E virus (HEV) and postweaning multisystemic wasting syndrome (PMWS) with lesions of hepatitis in pigs.Veterinary microbiology, 122 1-2
P. Halbur, C. Kasorndorkbua, C. Gilbert, D. Guenette, M. Potters, R. Purcell, S. Emerson, T. Toth, X. Meng (2001)
Comparative Pathogenesis of Infection of Pigs with Hepatitis E Viruses Recovered from a Pig and a HumanJournal of Clinical Microbiology, 39
N. McKeown, F. Martijn, P. Halbur, X. Meng (2004)
Molecular characterization of porcine TT virus, an orphan virus, in pigs from six different countries.Veterinary microbiology, 104 1-2
T. Kekarainen, J. Segalés (2009)
Torque teno virus infection in the pig and its potential role as a model of human infection.Veterinary journal, 180 2
Hong Zheng, L. Ye, X. Fang, Bao-zong Li, Yuhua Wang, Xiaoxiao Xiang, Lingbao Kong, Wei Wang, Yinchun Zeng, L. Ye, Zheng-hui Wu, Ying-long She, Xiaolin Zhou (2007)
Torque Teno Virus (SANBAN Isolate) ORF2 Protein Suppresses NF-κB Pathways via Interaction with IκB KinasesJournal of Virology, 81
S. Krakowka, J. Ellis (2008)
Evaluation of the effects of porcine genogroup 1 torque teno virus in gnotobiotic swine.American journal of veterinary research, 69 12
M. Takács, Á. Dencs, Csenge Csiszár, Andrea Hettmann, E. Rusvai, K. Szomor, V. Pálfi, B. Nagy (2008)
First description of swine Torque teno virus (TTV) and detection of a new genogroup in Hungary: short communication.Acta veterinaria Hungarica, 56 4
J Ellis, S Krakowka, M Lairmore, DA Bratanich, E Clark, G Allan, CL Hassard, B Meehan, K Martin, JS Kennedy, F McNeilly (1999)
Reproduction of lesions of postweaning wasting syndrome in gnotobioticJournal of Veterinary Diagnostic Investigation, 11
T. Leary, J. Erker, M. Chalmers, S. Desai, I. Mushahwar (1999)
Improved detection systems for TT virus reveal high prevalence in humans, non-human primates and farm animals.The Journal of general virology, 80 ( Pt 8)
J. Ellis, S. Krakowka, M. Lairmore, D. Haines, A. Bratanich, E. Clark, G. Allan, C. Konoby, L. Hassard, B. Meehan, K. Martin, J. Harding, S. Kennedy, F. Mcneilly (1999)
Reproduction of Lesions of Postweaning Multisystemic Wasting Syndrome in Gnotobiotic PigletsJournal of Veterinary Diagnostic Investigation, 11
J. Ellis, G. Allan, S. Krakowka (2008)
Effect of coinfection with genogroup 1 porcine torque teno virus on porcine circovirus type 2-associated postweaning multisystemic wasting syndrome in gnotobiotic pigs.American journal of veterinary research, 69 12
L. Bigarré, V. Béven, C. Boisséson, B. Grasland, N. Rose, P. Biagini, A. Jestin (2005)
Pig anelloviruses are highly prevalent in swine herds in France.The Journal of general virology, 86 Pt 3
Porcine circovirus type 2 (PCV2) and hepatitis E virus (HEV) are the most recently recognized causes of infectious hepatitis of pigs and may or may not act independently in the development of the disease. Recently it has been suggested that swine torque teno viruses (TTVs), in co-infections with some swine viral pathogens, may potentiate the severity of disease. In order to search for virological cofactors associated with infectious hepatitis in pigs, we investigated the liver tissues, to determine the presence of TTVs, PCV2 and HEV of naturally infected pigs and analysed the prevalence of both genogroups of the TTVs in the hepatitis lesions. Histopathological techniques, nested-polymerase chain reactions (nPCRs), polymerase chain reaction (PCR) and one-step reverse transcriptase polymerase chain reaction (RT-PCR) were applied to detect hepatitis lesions, TTVs genogroups 1 and 2, PCV2 and HEV infection. Of the livers examined 58% (29/50) had mild to moderate hepatitis and 74% (37/50), 56% (28/50) and 26% (13/50) samples were nPCR, PCR and RT-PCR positive for TTVs PCV2 and HEV respectively. TTVs were detected in 84% (16/19) of the samples which were determined to be of mild severity while present in almost all (90% or 9/10) samples identified as having moderate hepatitis lesions. Additionally, the livers of 12 out of 21 (57%) pigs without the hepatitis lesions were positive for TTVs. These results demonstrate an association between TTVs and infectious hepatitis of pigs in concomitant infections with PCV2 and/or HEV and indicated that TTVs may play a role as a cofactor in the pathogenesis of disease.
Veterinary Research Communications – Springer Journals
Published: Jul 31, 2010
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