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Vol. 69, No. 4, 1989 AND Department ojâ Cardiology and Experimental Cardiology, Academisch Medisch Centrum, University of Amsterdam, and the Interuniversity Cardiology Institute, Amsterdam, The Netherlands; and Department of Pharmacology, College of Physicians and Surgeons, Columbia University, New York, New York I. Introduction ......................................................... II. Ventricular in Acute Phase of Myocardial Ischemia and ................................................... A. Introduction ...................................................... .................................................... B. Animal models ............ C. Electrophysiological effects of acute myocardial ischemia .................. D. Mechanisms of during acute ischemia III. Delayed Ventricular in Subacute Phase .......................................... of Myocardial A. Spontaneous ventricular ............................... IV. Chronic Ventricular After ..................... ...................................................... A. Introduction B. Some characteristics of chronic in patients with ischemic heart disease .................................................. .................. C. Animal models of chronic ventricular .................................. D. Inducible ventricular E. Infarct models .................................................... ........ F. Electrophysiological properties of healing and healed infarcts ....................................... G. Mechanismsof H. Conclusions ....................................................... 1049 1051 1051 1053 1058 1076 1099 1099 1111 1111 1112 1115 1116 1121 1127 1140 1149 I. INTRODUCTION Sudden cardiac arrest is a leading cause of death in the Western industrialized world. In the United States alone, -1,200 individuals succumb to it daily (71,341,361). In the majority of cases sudden death is caused by ventricular and in particular
Physiological Reviews – The American Physiological Society
Published: Oct 1, 1989
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