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- Publisher
- Springer Journals
- Copyright
- Copyright © 2010 by Springer-Verlag
- Subject
- Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
- ISSN
- 0304-8608
- eISSN
- 1432-8798
- DOI
- 10.1007/s00705-009-0549-8
- pmid
- 19936613
- Publisher site
- See Article on Publisher Site
Abstract
Genome sequences of human rhinoviruses (HRV) have primarily been from stocks collected in the 1960s, with genomes and phylogeny of modern HRVs remaining undefined. Here, two modern isolates (hrv-A101 and hrv-A101-v1) collected ~8 years apart were sequenced in their entirety. Incorporation into our full-genome HRV alignment with subsequent phylogenetic network inference indicated that these represent a unique HRV-A , localized within a distinct divergent clade. They appear to have resulted from recombination of the hrv-65 and hrv-78 lineages. These results support our contention that there are unrecognized distinct HRV-A strains, and that recombination is evident in currently circulating strains.
Journal
Archives of Virology – Springer Journals
Published: Jan 1, 2010