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The Catalytic Mechanism of Nucleoside Diphosphate Kinases

The Catalytic Mechanism of Nucleoside Diphosphate Kinases Nucleoside diphosphate kinases catalyze the reversible transfer of the γ phosphate of nucleosidetriphosphates to nucleoside diphosphates. This minireview presents recent advances inunderstanding the reaction mechanism using steady-state and fast kinetic studies, X-raycrystallography, and site-directed mutagenesis. We also briefly discuss the physiological relevance ofin vitro studies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Bioenergetics and Biomembranes Springer Journals

The Catalytic Mechanism of Nucleoside Diphosphate Kinases

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References (47)

Publisher
Springer Journals
Copyright
Copyright © 2000 by Plenum Publishing Corporation
Subject
Life Sciences; Organic Chemistry; Biochemistry, general; Animal Biochemistry; Animal Anatomy / Morphology / Histology
ISSN
0145-479X
eISSN
1573-6881
DOI
10.1023/A:1005532912212
Publisher site
See Article on Publisher Site

Abstract

Nucleoside diphosphate kinases catalyze the reversible transfer of the γ phosphate of nucleosidetriphosphates to nucleoside diphosphates. This minireview presents recent advances inunderstanding the reaction mechanism using steady-state and fast kinetic studies, X-raycrystallography, and site-directed mutagenesis. We also briefly discuss the physiological relevance ofin vitro studies.

Journal

Journal of Bioenergetics and BiomembranesSpringer Journals

Published: Oct 6, 2004

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