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Saccharin Intake Predicts Ethanol Intake in Genetically Heterogeneous Rats as Well as Different Rat Strains

Saccharin Intake Predicts Ethanol Intake in Genetically Heterogeneous Rats as Well as Different... Saccharin and ethanol intakes were measured in seven strains of rats known to differ in their preferences for ethanol: The Fawn‐Hooded (FH), alcohol‐preferring (P) and Maudsley Reactive rats have been reported to drink ethanol voluntarily, whereas the alcohol‐nonpreferring, Maudsley Nonreactive and Flinders Line (FSL and FRL) rats do not. Saccharin and ethanol intakes were highly correlated (r =+0.61) over all strains, with the FH rats drinking the most of both solutions. Correlation coefficients between pairs of drinking versus nondrinking rat strains were even higher. In a second experiment, genetically heterogeneous F2 progeny from cross‐breeding the ethanol‐preferring FH rats with the ethanol‐nonpreferring Flinders Resistant Line (FRL) rats were studied. The results indicated a high positive correlation between saccharin and ethanol intakes (+0.65). These findings suggest that the association between saccharin and ethanol intakes previously reported in rat strains with different preferences for ethanol may have a similar genetic basis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alcoholism: Clinical & Experimental Research Wiley

Saccharin Intake Predicts Ethanol Intake in Genetically Heterogeneous Rats as Well as Different Rat Strains

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References (30)

Publisher
Wiley
Copyright
Copyright © 1993 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0145-6008
eISSN
1530-0277
DOI
10.1111/j.1530-0277.1993.tb00777.x
Publisher site
See Article on Publisher Site

Abstract

Saccharin and ethanol intakes were measured in seven strains of rats known to differ in their preferences for ethanol: The Fawn‐Hooded (FH), alcohol‐preferring (P) and Maudsley Reactive rats have been reported to drink ethanol voluntarily, whereas the alcohol‐nonpreferring, Maudsley Nonreactive and Flinders Line (FSL and FRL) rats do not. Saccharin and ethanol intakes were highly correlated (r =+0.61) over all strains, with the FH rats drinking the most of both solutions. Correlation coefficients between pairs of drinking versus nondrinking rat strains were even higher. In a second experiment, genetically heterogeneous F2 progeny from cross‐breeding the ethanol‐preferring FH rats with the ethanol‐nonpreferring Flinders Resistant Line (FRL) rats were studied. The results indicated a high positive correlation between saccharin and ethanol intakes (+0.65). These findings suggest that the association between saccharin and ethanol intakes previously reported in rat strains with different preferences for ethanol may have a similar genetic basis.

Journal

Alcoholism: Clinical & Experimental ResearchWiley

Published: Apr 1, 1993

Keywords: ; ; ;

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